Navigation Links
Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression

ent degradation involves a number of different proteins, including proteins that bind to the AU regions of the mRNA. These binding events may play a role in the stability and degradation of the mRNA. Despite much research over the last few years into exactly how this works, the question had not been answered.

"So far, it has not really been clear what the mechanism is," says Han.

Now, Han and his colleagues are reporting in their Cell paper that the degradation mechanism involves tiny pieces of RNA known as microRNA. These microRNAs, which are generally only 17 or 20 nucleotides, were first identified about 20 years ago, and in the past few years scientists have realized that microRNA is a new category of regulatory molecules and identified hundreds of different microRNA in mammals.

The big question was, what are they doing? About a dozen years ago a few studies came out that showed that microRNA could suppress translation in certain Drosophila (fruit fly) genes if those genes contained sequences complementary to the microRNA's sequence. But finding the targets of these microRNA proved difficult, and by the turn off the century, only a few had been identified.

When the human genome was solved and published in 2001, many scientists thought that the task of finding the mRNA to which the microRNA bound would be relatively straightforward. After all, a short stretch of nucleotides like a microRNA should be expected to bind to a piece of RNA of equal length and complementary sequence. And since these sequences of the microRNA were known, a computer search through the three billion letters of the human genome should find those matching sequences.

But this didn't work. The homology searches yielded far fewer targets than expected and could not account for all known microRNAs. The reason, says Han, is that scientists were trying to predict the microRNA targets using the sequence homology of the full-length microRNAs.

In their
'"/>

Source:The Scripps Institute


Page: 1 2 3 4

Related biology news :

1. A new way of looking at molecular motors
2. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
3. MicroRNAs play a big part in gene regulation - and evolution
4. MicroRNA tweaks protein that controls early heart development
5. MicroRNAs have shaped the evolution of the majority of mammalian genes
6. MicroRNA gene that regulates lifespan found by Yale scientists
7. MicroRNA may have fail-safe role in limb development
8. MicroRNAs can be tumor suppressors
9. MicroRNA helps prevent tumors
10. MicroRNAs as tumor suppressors
11. Master gene controls healing of skin in fruit flies and mammals
Post Your Comments:
(Date:7/24/2014)... study has identified two factors that characterize sustainable ... production of highly qualified physics teachers. Specifically, one ... physics teacher education in combination with institutional motivation ... viable. Science, Technology, Engineering and Math (STEM) teacher ... study points the way for institutions seeking to ...
(Date:7/24/2014)... team of researchers has developed a new nanoscale agent ... method for assessing the function and properties of the ... diagnosis and treatment of gut diseases. , ... syndrome and inflammatory bowel disease all occur in the ... patients with diseases such as diabetes and Parkinson,s. ...
(Date:7/24/2014)... Forest is a hotspot of biodiversity and one of ... and toads) in the world. However, current levels of ... years has been an increase in the description of ... advance of molecular techniques and availability of samples for ... of samples for molecular and morphological analysis, researchers from ...
Breaking Biology News(10 mins):Creating sustainable STEM teacher preparation programs 2New imaging agent provides better picture of the gut 2A tiny new species of frog from Brazil with a heroic name 2
... March 22, 2010 Before you dig in to your next ... on pure maple syrup. That,s because University of Rhode Island ... more than 20 compounds in maple syrup from Canada that have ... in maple syrup. In addition, eight of the compounds have been ...
... DURHAM, N.C. -- Scientists at Duke University Medical Center ... expansion and regeneration of hematopoietic (blood-forming) stem cells in ... the journal Nature Medicine , may help researchers ... therapy: the fact that stem cells are so ...
... A potential new energy source so controversial that people ... acceptance by the mainstream scientific community. That,s the conclusion of ... the topic "cold fusion" being held here for ... 239th National Meeting of the American Chemical Society (ACS). ...
Cached Biology News:URI pharmacy researcher finds beneficial compounds in pure maple syrup 2URI pharmacy researcher finds beneficial compounds in pure maple syrup 3Newly identified growth factor promotes stem cell growth, regeneration 2'Cold fusion' moves closer to mainstream acceptance 2'Cold fusion' moves closer to mainstream acceptance 3'Cold fusion' moves closer to mainstream acceptance 4
(Date:7/24/2014)... equipment, trained personnel, and detection dogs to safeguard ... A revolutionary new electronic chip with nano-sized chemical ... easier. , The groundbreaking nanotechnology-inspired sensor, devised by ... School of Chemistry and Center for Nanoscience and ... picks up the scent of explosives molecules better ...
(Date:7/24/2014)... Professor of Engineering at the University of Delaware, ... problems in energy engineering, environmental sustainability and electronics. ... porous rock with a well-defined, crystalline structure. At ... precisely decided that zeolites can separate molecules with ... angstrom (one-tenth of a nanometer), making them useful ...
(Date:7/24/2014)... Research and Markets has announced ... Analytical Instruments Market 2014-2018" report to their offering. ... Genomics is the study of the gene and its ... and functions of proteomes or sets of proteins by ... involves the mapping of genes and DNA sequencing to ...
(Date:7/24/2014)... 2014  CorMedix Inc. (NYSE MKT: CRMD), a ... products for the prevention and treatment of cardiorenal ... on July 18, 2014 from the NYSE MKT ... CorMedix plan to regain compliance with continued listing ... NYSE-MKT is continuing the Company,s listing and has ...
Breaking Biology Technology:Nano-sized chip 'sniffs out' explosives far better than trained dogs 2University of Delaware researcher describes new approach for creating organic zeolites 2Global Genomics and Proteomics Analytical Instruments Market 2014-2018: Key Vendors are Agilent, Bio-Rad , F. Hoffmann, La Roche, Illumina, PerkinElmer and Thermo Fisher Scientific 2CorMedix, Inc. Granted Extension of NYSE-MKT Listing 2CorMedix, Inc. Granted Extension of NYSE-MKT Listing 3
... new high-tech networking event starting in Appleton, Wisconsin. ... angel investors and others who live in the ... Fleck, Tobey Andropolis and Bob Pankratz insist that ... business enterprise. Instead, the Hive is devoted to ...
... Byrne Chapman, CIO of American Family When Byrne Chapman ... the variations he imagined. Yet the business needs at American ... Chapmans organization has started handling terabytes of storm data from ... predict storm paths and match the predictions to the locations ...
... plans to close all its offices on December 13 for ... which has been in development for the past week, will ... add newer programming languages. Employee training will take place on ... existing system has been in place since the 1970s. Implementation ...
Cached Biology Technology:A new high-tech networking event buzzes in Appleton 2A new high-tech networking event buzzes in Appleton 3American Family CIO takes entrepreneurial approach to innovation 2American Family CIO takes entrepreneurial approach to innovation 3American Family CIO takes entrepreneurial approach to innovation 4
Umbilical cord blood CD14+ Monocytes, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Monocytes, B Cells and NK Cells...
Umbilical cord blood basophils, For immunohistochemistry (IHC)...
Human peripheral blood neutrophils, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Granulocytes...
Human peripheral blood CD14+ monocytes, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Monocytes, B Cells, NK Cells and Stem Cells...
Biology Products: