Navigation Links
Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression

ent degradation involves a number of different proteins, including proteins that bind to the AU regions of the mRNA. These binding events may play a role in the stability and degradation of the mRNA. Despite much research over the last few years into exactly how this works, the question had not been answered.

"So far, it has not really been clear what the mechanism is," says Han.

Now, Han and his colleagues are reporting in their Cell paper that the degradation mechanism involves tiny pieces of RNA known as microRNA. These microRNAs, which are generally only 17 or 20 nucleotides, were first identified about 20 years ago, and in the past few years scientists have realized that microRNA is a new category of regulatory molecules and identified hundreds of different microRNA in mammals.

The big question was, what are they doing? About a dozen years ago a few studies came out that showed that microRNA could suppress translation in certain Drosophila (fruit fly) genes if those genes contained sequences complementary to the microRNA's sequence. But finding the targets of these microRNA proved difficult, and by the turn off the century, only a few had been identified.

When the human genome was solved and published in 2001, many scientists thought that the task of finding the mRNA to which the microRNA bound would be relatively straightforward. After all, a short stretch of nucleotides like a microRNA should be expected to bind to a piece of RNA of equal length and complementary sequence. And since these sequences of the microRNA were known, a computer search through the three billion letters of the human genome should find those matching sequences.

But this didn't work. The homology searches yielded far fewer targets than expected and could not account for all known microRNAs. The reason, says Han, is that scientists were trying to predict the microRNA targets using the sequence homology of the full-length microRNAs.

In their
'"/>

Source:The Scripps Institute


Page: 1 2 3 4

Related biology news :

1. A new way of looking at molecular motors
2. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
3. MicroRNAs play a big part in gene regulation - and evolution
4. MicroRNA tweaks protein that controls early heart development
5. MicroRNAs have shaped the evolution of the majority of mammalian genes
6. MicroRNA gene that regulates lifespan found by Yale scientists
7. MicroRNA may have fail-safe role in limb development
8. MicroRNAs can be tumor suppressors
9. MicroRNA helps prevent tumors
10. MicroRNAs as tumor suppressors
11. Master gene controls healing of skin in fruit flies and mammals
Post Your Comments:
(Date:4/17/2014)... NY, April 17, 2014The development of stem cell therapies ... ability to characterize stem cell populations based on cell ... discovered a new marker that is highly expressed in ... cord blood, which they describe in an article in ... Mary Ann Liebert, Inc., publishers. The article is available ...
(Date:4/17/2014)... anthrax detection cartridge developed at Sandia National Laboratories and ... easier, faster and cheaper. , Bacillus anthracis ... in soils all over the world and can cause ... animals. The bacteria can survive in harsh conditions for ... may occur through skin contact, inhalation of spores or ...
(Date:4/17/2014)... produce hydrogen sulfide in order to properly multiply and ... the Center for Craniofacial Molecular Biology at the Herman ... Shi, principal investigator on the project, said the presence ... flow of calcium ions. The essential ions activate a ... the creation of new bone tissue, and keeps the ...
Breaking Biology News(10 mins):Pocket-sized anthrax detector aids global agriculture 2Pocket-sized anthrax detector aids global agriculture 3
... Researchers have discovered how the protein Hap1, which is ... between circulating insulin in the blood and the neural ... of the neural pathway used by hormones to regulate ... targets for treating eating disorders and obesity. The ...
... The Walter and Eliza Hall Institute, using a mouse ... the formation of all breast tissue. This discovery lays ... develops. The identification of the breast stem cell is ... develops and how rogue cells evade current therapies. ...
... of an essential piece of the telomerase enzyme, an ... Understanding the physical shape of the protein has led ... immortalize cells ?and should help scientists design broadly effective ... structural information about the enzyme has hindered progress in ...
Cached Biology News:Hap1 protein links circulating insulin to brain circuits that regulate feeding behavior in mice 2Faults in newly discovered breast stem cells may lead to tumours 2Groovy protein essential for promoting cancer development 2Groovy protein essential for promoting cancer development 3Groovy protein essential for promoting cancer development 4
(Date:1/14/2014)... (PRWEB) January 14, 2014 In recent ... motives and methods in product development and promotion has ... industry. This mistrust, fueled by concerns about the insidious ... by reports of spectacular fines to the world’s biggest ...
(Date:1/14/2014)... January 14, 2014 Global Record ... innovative information technology solutions for patients, physicians, the ... stakeholders, announced today the signing of a three-year ... and Drug Administration (FDA). This initiative is ...
(Date:1/14/2014)... and Cardiff, UK (PRWEB) January 13, 2014 ... development leader with more than 20 years in the ... optics and photonics . Hainsey will serve as the ... to have Dr. Hainsey join SPIE as our Technology ...
(Date:1/14/2014)... Rochester, NY (PRWEB) January 14, 2014 During ... is now known as “The Doctor’s Plague.” In this time ... their hands. This led, at times, to the death of ... staff today don’t know that they may be unwittingly transmitting ...
Breaking Biology Technology:The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 3
... Corp.,(Nasdaq: GENZ ) announced today that it ... for the treatment of Hunter syndrome.,Elaprase is an ... Inc., and Genzyme is commercializing the product in ... with Shire. Genzyme intends,to launch Elaprase this quarter, ...
... Inc. (Nasdaq:,BIOD) today announced that Solomon Steiner, Chairman and CEO ... 2007 in San,Francisco, CA on October 11th at 11:00 AM ... live audio webcast of the,presentation in the investor relations section ... presentation will be available for,14 days. About Biodel Inc. ...
... new products, Skin Optimizer and Hyaluronic Acid Complex, promote ... skin and ... Formulas, recognized in,July by Nutrition Business Journal, selected BioCell Collagen ... the,effectiveness of two new Jarrow Formulas products -- Skin Optimizer ...
Cached Biology Technology:Genzyme Receives Approval to Market Elaprase(R) in Japan 2Genzyme Receives Approval to Market Elaprase(R) in Japan 3Genzyme Receives Approval to Market Elaprase(R) in Japan 4Biodel Inc. to Present at BIO InvestorForum 2007 Conference on October 11, 2007 2Jarrow Formulas Launches New Products Featuring BioCell Collagen II(R) 2
Amino-acids and Derivatives Rabbit Anti-conjugated L-isoleucine Polyclonal Antibody...
Anti-MMP-25 (Membrane-type MMP-6, Mt6MMP), hinge region; rabbit host...
Sheep polyclonal to Streptomycin ( Abpromise for all tested applications). Antigen: Chemical / Small Molecule: Streptomycin conjugated to BSA....
Mouse monoclonal [SPM217] to Secretory Component Glycoprotein ( Abpromise for all tested applications)....
Biology Products: