Navigation Links
Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression

tasks of every cell in the body because many of our genes encode proteins that may only be needed occasionally. Indeed, having some of these proteins around when they are not needed can create any number of problems for an organism, and failing to properly control gene expression can be fatal. Indeed, aberrant expression of genes is the underlying cause of many different diseases.

For example, the expression of inflammatory cytokine proteins by immune system cells must be finely tuned so that these proteins do not cause more damage to the body than the bacterial infection they were produced to defeat. Excessive inflammation can lead to organ failure and death, and this is exactly what happens when people are stricken with septic shock. Likewise, the loss of control of genetic expression is the underlying cause of various forms of cancer--for instance the overexpression of genes that cause the cell to grow and the suppression of genes that curb cell growth.

Humans and other animals have evolved many overlapping ways of controlling gene expression. Many different controls determine when a DNA gene is transcribed into mRNA, and when and how the mRNA is translated into a protein. Many proteins are also tightly controlled through various post-translational modifications that activate or deactivate them.

Translation is the final step in the expression of every gene, and the cell exercises control over this process in numerous ways, and hence expression of a gene. One way to exert this control is ensuring that mRNAs that are not needed are destroyed. One of the ways that nature has evolved for destroying certain mRNAs is making them inherently unstable and prone to degradation.

This inherent instability is built into the 3' tail of the mRNA in the form of noncoding stretches of RNA called AU-rich elements. Lots of genes, including inflammatory cytokines and cancer-causing oncogenes, have these AU-rich elements built in.

AU-rich elem
'"/>

Source:The Scripps Institute


Page: 1 2 3 4

Related biology news :

1. A new way of looking at molecular motors
2. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
3. MicroRNAs play a big part in gene regulation - and evolution
4. MicroRNA tweaks protein that controls early heart development
5. MicroRNAs have shaped the evolution of the majority of mammalian genes
6. MicroRNA gene that regulates lifespan found by Yale scientists
7. MicroRNA may have fail-safe role in limb development
8. MicroRNAs can be tumor suppressors
9. MicroRNA helps prevent tumors
10. MicroRNAs as tumor suppressors
11. Master gene controls healing of skin in fruit flies and mammals
Post Your Comments:
(Date:10/16/2014)... Melbourne researchers have challenged conventional thinking on how the ... new mechanism for how bowel cancer starts. , The ... maintaining and regenerating the ,crypts, that are a feature ... are involved in bowel cancer development, a controversial finding ... existence. , Using 3D imaging technologies, Dr Chin Wee ...
(Date:10/16/2014)... 2014 NXT-ID, Inc. (NASDAQ: NXTD ... authentication company focused on the growing mobile commerce market ... Wocket™, the Smart Wallet, at the 13 th ... leading global conference on the intersection of technology and ... Anderson , founder and publisher of the Strategic News ...
(Date:10/15/2014)... Gauß-Allianz has admitted Johannes Gutenberg University Mainz (JGU) ... science hub continues to maintain a significant nationwide ... , "The acceptance of Johannes Gutenberg University Mainz ... a milestone in the national and international competition ... state of Rhineland-Palatinate can be proud that Mainz ...
Breaking Biology News(10 mins):Cryptic clues drive new theory of bowel cancer development 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3
... differences seen among patients with schizophrenia may be explained by ... risk genes. These findings appear in a new imaging-genetics study ... The study revealed that people with schizophrenia who had ... to develop the illness at a younger age and had ...
... like a bomb shelter, Perry Gerakines makes something ordinary yet truly ... No, this ice needs such intense cold and low pressure to ... Earth. And when Gerakines makes the ice, he must keep the ... pollen. These ultrathin layers turn out to be perfect for ...
... cells during puberty to help navigate the complex social world ... current issue of the Proceedings of the National Academy ... cells you,re born with are all you get. After studies ... wisdom held that such growth was limited to two brain ...
Cached Biology News:Single gene might explain dramatic differences among people with schizophrenia 2NASA Goddard lab works at extreme edge of cosmic ice 2NASA Goddard lab works at extreme edge of cosmic ice 3NASA Goddard lab works at extreme edge of cosmic ice 4Brain adds cells in puberty to navigate adult world 2
(Date:10/22/2014)... Shimadzu Scientific Instruments introduces its Open Solution QuantAnalytics(TM) ... management and clinical markets. The software increases the speed ... users to highlight and review results that are of ... to filter results by group or based on a ... need to sift through analytes of no interest. In ...
(Date:10/22/2014)... WriteResult, LLC – a premier provider of ... a team of researchers from Yale University’s School of ... to provide electronic questionnaire data collection through use of ... in May, aims to evaluate the impact of a ... and participation in urban agriculture to impact their consumption ...
(Date:10/22/2014)... Grace Century, a private equity consultancy ... the addition of Dr. Yousef “Josh” Siddiqui , ... Dr. Siddiqui will provide further healthcare expertise to its ... University College Medical School in the late ... 2001. With further certification as a General Practitioner (GP), ...
(Date:10/22/2014)... According to new market research report "Cloud Professional ... & Support), by Service Model (SaaS, PaaS, IaaS), ... & Community)) - Global Forecast to 2019", published ... Services Market into various sub-segments with an in-depth ... the drivers and restraints for this market with ...
Breaking Biology Technology:Shimadzu Releases QuantAnalytics Open Access LCMS Software Package for Clinical Applications 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 3Dr. Yousef Siddiqui joins the Grace Century Advisory Team 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 4Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 5
... 2011 During a ,Day of Science, more than 30 ... what it was like to be scientists for a day ... Inc. (S2S). The "A Day in the Life of a ... programs offered by S2S that seeks to address the fact ...
... (Nasdaq: DNDN ) today announced that management will present ... in New York City, NY on May 25, 2011 at 1:00 ... Palos Verdes, CA on June 7, 2011 at 2:00 p.m. PT ... available for replay from Dendreon,s website, www.dendreon.com .  If you ...
... BRISBANE, Calif., May 19, 2011 InterMune, Inc. (NASDAQ: ... of its 2011 Analyst Day presentations on Thursday, May ... in New York.  Presentations by InterMune,s executive management team ... and a comprehensive update of InterMune,s commercial and scientific ...
Cached Biology Technology:Local Partnership Addresses Lagging Scores and Interest in Science and Math Among Students 2Local Partnership Addresses Lagging Scores and Interest in Science and Math Among Students 3InterMune to Webcast 2011 Analyst Day Presentations 2
... SPA Screening Assay, 5 x ... eliminate lengthy sample extraction procedures and ... 1.32-84.28 ng/ml (4-256 pmol/ml).Sensitivity: 0.65 ng/ml ... C. Category: Drug Screening & Cellular ...
...
Request Info...
... Streptavidin-Horseradish Peroxidase Conjugate, 2 ... reporter enzyme molecules for ... in situ hybridization applications.High ... & Labeling & Detection, ...
Biology Products: