Navigation Links
Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression

tasks of every cell in the body because many of our genes encode proteins that may only be needed occasionally. Indeed, having some of these proteins around when they are not needed can create any number of problems for an organism, and failing to properly control gene expression can be fatal. Indeed, aberrant expression of genes is the underlying cause of many different diseases.

For example, the expression of inflammatory cytokine proteins by immune system cells must be finely tuned so that these proteins do not cause more damage to the body than the bacterial infection they were produced to defeat. Excessive inflammation can lead to organ failure and death, and this is exactly what happens when people are stricken with septic shock. Likewise, the loss of control of genetic expression is the underlying cause of various forms of cancer--for instance the overexpression of genes that cause the cell to grow and the suppression of genes that curb cell growth.

Humans and other animals have evolved many overlapping ways of controlling gene expression. Many different controls determine when a DNA gene is transcribed into mRNA, and when and how the mRNA is translated into a protein. Many proteins are also tightly controlled through various post-translational modifications that activate or deactivate them.

Translation is the final step in the expression of every gene, and the cell exercises control over this process in numerous ways, and hence expression of a gene. One way to exert this control is ensuring that mRNAs that are not needed are destroyed. One of the ways that nature has evolved for destroying certain mRNAs is making them inherently unstable and prone to degradation.

This inherent instability is built into the 3' tail of the mRNA in the form of noncoding stretches of RNA called AU-rich elements. Lots of genes, including inflammatory cytokines and cancer-causing oncogenes, have these AU-rich elements built in.

AU-rich elem
'"/>

Source:The Scripps Institute


Page: 1 2 3 4

Related biology news :

1. A new way of looking at molecular motors
2. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
3. MicroRNAs play a big part in gene regulation - and evolution
4. MicroRNA tweaks protein that controls early heart development
5. MicroRNAs have shaped the evolution of the majority of mammalian genes
6. MicroRNA gene that regulates lifespan found by Yale scientists
7. MicroRNA may have fail-safe role in limb development
8. MicroRNAs can be tumor suppressors
9. MicroRNA helps prevent tumors
10. MicroRNAs as tumor suppressors
11. Master gene controls healing of skin in fruit flies and mammals
Post Your Comments:
(Date:4/17/2014)... N.M. A credit-card-sized anthrax detection cartridge developed at ... business makes testing safer, easier, faster and cheaper. ... anthrax, is commonly found in soils all over the ... in both humans and animals. The bacteria can survive ... B. anthracis may occur through skin contact, ...
(Date:4/17/2014)... in German . ... they also provide us with a continuous stream of information ... or sit still in a car the world glides ... retinas. Seemingly without effort, our brain calculates self-motion from this ... and a steady gaze during our own movements. Together with ...
(Date:4/17/2014)... hydrogen sulfide in order to properly multiply and form ... Center for Craniofacial Molecular Biology at the Herman Ostrow ... principal investigator on the project, said the presence of ... of calcium ions. The essential ions activate a chain ... creation of new bone tissue, and keeps the breakdown ...
Breaking Biology News(10 mins):Pocket-sized anthrax detector aids global agriculture 2Pocket-sized anthrax detector aids global agriculture 3How vision makes sure that little fish do not get carried away 2How vision makes sure that little fish do not get carried away 3How vision makes sure that little fish do not get carried away 4
... it may sound like an oxymoron, a University of Iowa ... skull from a "pygmy-sized" giant panda -- the earliest-known ancestor ... some two million years ago. , The ancestor of today's ... Ciochon, UI professor of anthropology. Ciochon (pronounced schuh-HON) is a ...
... the link between the way an animal moves and the dimensions ... semicircular canals of the inner ear on each side of the ... on 26 June in the print edition of the Proceedings of ... edition during the week of 18 to 22 June. , ...
... cells that is altered by genetic mutations recently identified in ... mutations affect cellular function and could provide a target for ... a team of Emory University scientists will be published June ... journal. , Parkinson disease is a degenerative disorder ...
Cached Biology News:UI anthropologist, colleagues discover remains of earliest giant panda 2Reconstructing the biology of extinct species: A new approach 2Researchers identify protein pathway involved in Parkinson disease development 2
(Date:1/15/2014)... January 15, 2014 The Microcompetition with Foreign ... disease. One of these latent viruses is the Epstein Barr ... (RA). Rheumatoid arthritis (RA) is a chronic inflammatory disease that ... study found that RA patients have high concentrations of EBV ...
(Date:1/15/2014)... Freeslate, Inc ., the leading ... Lupin Limited, one of India’s top five pharmaceutical companies, ... System for high throughput solid form screening. ... a wide range of quality, affordable generic and branded ...
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: 6 p.m. ... Road, Warrington, Pa. , Details: The Hepatitis B ... a cure for hepatitis B and improving the quality of ... Ball on Friday, April 11 at Warrington Country Club in ...
(Date:1/14/2014)... , Jan. 14, 2014  3D Communications, a leading provider of strategic ... business, and media events in the United States ... associate Virginia Cox , JD, is returning to the firm,s ... Cox re-joins 3D after more than two years of service ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Former FDA Associate Commissioner Returns To 3D Communications 2
... of enzymes routinely used to synthesizing some of nature's most ... new way to expand on nature's chemical creativity to make ... 1) in the journal Science , a team led ... the University of Wisconsin-Madison , describes the discovery of ...
... the new darling of Wall Street. In the past ... private equity firms, venture capital firms, and hedge funds. ... trading multiples in excess of $5 per gallon of ... EBITDA, and 1,000x trailing four quarters of net income. ...
... - When it comes to attracting venture capital, Wisconsin has ... Investors on the East and West coasts have basically stuck ... in the Heartland, with the exception of a few states ... have been signs that a few flights ferrying venture capitalists ...
Cached Biology Technology:UW finds new path to anti-cancer agents 2UW finds new path to anti-cancer agents 3Ethanol producers are at a crossroads 2Ethanol producers are at a crossroads 3Ethanol producers are at a crossroads 4Ethanol producers are at a crossroads 5Ethanol producers are at a crossroads 6That blip on the national venture capital radar screen may be Wisconsin 2That blip on the national venture capital radar screen may be Wisconsin 3
Anti-TWIK-1 Immunogen: Purified peptide from amino acids 53-69 of human TWIK-1 (Accession number O00180)....
Monoclonal 8C2.1 is specific for Bunyavirus G1 as tested by neutralization, immunoprecipitation and immunobinding assays....
BI-1 Polyclonal Antibody Storage Temperature: -20C Shipping: gel pack Shelf-Life: 12 months...
...
Biology Products: