Navigation Links
Controlling protein diversity

Proteins called coactivators control the process by which a single gene can initiate production of several proteins in a process called alternative splicing, said Baylor College of Medicine researchers in a report that appears in today's issue of the journal Molecular Cell. "A major question in biology today is how human cells with 30,000 genes produce at least 120,000 proteins," said Dr. Bert O'Malley, chair of the BCM department of molecular and cellular biology. The answer is a process called alternative splicing in which certain information from a gene is left out or included, changing the format of the resulting protein.

In other words, if the information in a gene is like the elements of a computer code, leaving out some of the code results in a very different program than what would have resulted if all the components had been included or different parts had been left out. In this instance, leaving out part of the gene changes the protein.

"The question is, 'How is this controlled?'" said O'Malley.

He and his colleagues have shown in previous studies that hormones like estrogen and progesterone can change the amounts of proteins made by their target genes. When hormone binds to receptors inside the cells, they are activated to seek out target genes. They then recruit the coactivators ?in this case CAPERá and CAPERâ. These coactivators not only cause the gene to begin the process that results in protein production, they also determine what kind of RNA (a kind of genetic template for the protein) is made as well as what kind of protein results.

"This subgroup of coactivators, when brought to the gene, can enhance the amount of RNA made off the gene or the quantitative expression of that gene as well as qualitatively change what comes off the gene in terms of what protein is made," said O'Malley. These coactivators are unusual in that they can both control alternative splicing that results in different proteins being made as well a s the production of RNA.


'"/>

Source:Baylor College of Medecine


Related biology news :

1. Controlling wildlife trade key to preventing health crises, study says
2. Controlling antibiotics and antibiotic resistance in hospitals
3. New, automated tool successfully classifies and relates proteins in unprecedented way
4. New binding target for oncogenic viral protein
5. Controversial drug shown to act on brain protein to cut alcohol use
6. Timing is everything: First step in protein building revealed
7. UWs Rosetta software to unlock secrets of many human proteins
8. Researchers find how protein allows insects to detect and respond to pheromones
9. Signaling protein builds bigger, better bones in mice
10. Ancient olfaction protein is shared by many bugs, offering new pest control target
11. Automatic extraction of gene/protein biological functions from biomedical text
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/21/2017)... , February 21, 2017 ... 70 Millionen US-Dollar wachsen. Nach einem Gespräch mit mehr als ... einige Hindernisse zu überwinden gilt, um diese Prognose zu ... ... anderem die Mobilisierung der finanziellen Mittel für die Biobank, ...
(Date:2/13/2017)... -- Former 9/11 Commission border counsel and Special Counsel ... of Identity Strategy Partners, LLP, today releases the ... Order: Protecting the Nation From Foreign Terrorist Entry Into ... President Trump,s ,Travel Ban, Executive Order gains more notoriety ... travel ban, it is important that our national discourse ...
(Date:2/8/2017)... AWRE ), a leading supplier of biometrics software ... year ended December 31, 2016. Revenue for ... $6.9 million in the same quarter last year. Operating income ... to $2.6 million in the fourth quarter of 2015. Net ... or $0.02 per diluted share, which compares to $1.8 million, ...
Breaking Biology News(10 mins):
(Date:2/24/2017)... ... February 24, 2017 , ... Chef Jodi Abel has ... Making stops in several cities, she gained a number of delicious recipes and ... Stellenbosch, a town in South Africa’s Western Cape province. It is internationally renowned ...
(Date:2/24/2017)... 2017  Aethlon Medical, Inc. (Nasdaq: AEMD ... Chairman and CEO, Jim Joyce . ... last Saturday, Bill Gates warned world leaders ... than nuclear weapons. Mr. Gates expressed his concern, which ... that scientific terrorists have access to the necessary tools ...
(Date:2/24/2017)... , Feb. 24, 2017  Driven by ... biotechnology are now the fastest growing categories, finds ... Specialty Actives in Personal Care: Multi-regional Market Analysis ... and management consulting firm Kline. "Biotechnology ... that make them more effective for skin and ...
(Date:2/24/2017)... (PRWEB) , ... February 24, 2017 , ... FireflySci, Inc ... Founded in late 2014, FireflySci had the goal of bringing their powerful cuvette ... continues to shape the path that FireflySci is going on as they add yet ...
Breaking Biology Technology: