Navigation Links
Computers close in on protein structure prediction

Rosetta@home lets public participate in structure prediction.

Computers can predict the detailed structure of small proteins nearly as well as experimental methods, at least some of the time, according to new studies by Howard Hughes Medical Institute researchers.

The findings, which were reported in the September 16, 2005, issue of the journal Science, provide a glimmer of hope that scientists eventually may be able to determine the structure of proteins from their genomic sequences, a problem that has seemed insurmountable.

"For more than 40 years, people have known the amino acid sequence of a protein specifies its three-dimensional structure, but no one has been able to translate the sequence into an accurate structure," said senior author David Baker, an HHMI researcher at the University of Washington. "The reason this research is exciting is that we're showing progress in predicting the structure from the sequence. It's not that the problem is solved, but that there is hope."

Proteins are biological machines, and scientists need to determine their structures to understand how the proteins work. Now, scientists determine structures exclusively by measuring the atomic characteristics of proteins in the lab. In contrast, "in this case, we never touched a test tube," Baker said. "We gave it to a computer and said, 'go.'"

In the study, a sophisticated computer program folded 17 short strings of amino acids into 100,000 possible variations. When the researchers compared the best predictions to the actual structures solved earlier by other scientists using experimental techniques, they had the same success rate as the best hitters in major league baseball.

"We achieved almost atomic resolution in structure prediction for about one-third of our benchmark set of small proteins," said first author Philip Bradley, a postdoctoral fellow in Baker's lab. "It is a real step forward to achieve structures that are in some way comp
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3 4

Related biology news :

1. Computers to be used to find blueprint for new influenza drug
2. Computers to save unique type of American red squirrel
3. Chemicals in tattoo inks need closer scrutiny
4. Doctors closer to using gene analysis to help trauma patients
5. Proteomics brings researchers closer to understanding microbes that produce acid mine drainage
6. New results validating Pall prion reduction filter disclosed at ISBT Congress
7. Scientists closer to new cancer detection method
8. Getting close to nature is good for you
9. Scientists observe how a close bond activates the immune system
10. Stroke treatment a step closer after trial
11. Multiple genes permit closely related fish species to mix and match their color vision
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Computers close protein structure prediction

(Date:7/10/2014)... , July 7, 2014 Fingerprint Cards, ... major design win (DW). A Chinese Top 5 smartphone OEM ... start of mass production in October 2014.   ... Top 5 smartphone OEM, which has a planned date for ... target sales volume for this phone of 3 million units. ...
(Date:7/10/2014)... , July 9, 2014 The widespread ... in large part by meaningful use and related ... providers interact with laboratory information. Now, more than ... field of clinical informatics in order to deliver ... To address the educational needs of pathologists in ...
(Date:7/10/2014)... or soap might not be ape friendly, and the situation ... in the Cell Press journal Current Biology on ... already led to the conversion of Southeast Asian forest into ... guidelines are not put in place very soon, researchers say ... Africa will be bad news for great apes there as ...
Breaking Biology News(10 mins):FPC Wins DW for 1021 Touch Sensor for Flagship Smartphone from Chinese Top 5 Smartphone OEM 2New Clinical Informatics Curriculum Prepares Future Pathologists 2New Clinical Informatics Curriculum Prepares Future Pathologists 3New Clinical Informatics Curriculum Prepares Future Pathologists 4Hunger for vegetable oil means trouble for Africa's great apes 2
... Award of the American Association for the Advancement of ... "for his transformative impact and contributions towards the production ... sciences." Tchounwou, associate dean of graduate studies and ... Technology at Jackson State University in Jackson, Miss., will ...
... have sustained farming villages in the arid southwestern United ... runoff and social and economic factors that favor modernism ... results reflect similar changes around the world, where once ... provide benefits of modern living but also the uncertainties ...
... of a symposium on Saturday, February 15, at the 2014 Annual ... Chicago. The session, which features two members of Congress and ... place 10:00-11:30 a.m. CST in Grand Ballroom B of the Hyatt ... of the Golden Goose Award will be announced. ...
Cached Biology News:2013 AAAS Mentor Award goes to Paul B. Tchounwou of Jackson State University 22013 AAAS Mentor Award goes to Paul B. Tchounwou of Jackson State University 3Dartmouth study shows US Southwest irrigation system facing decline after 4 centuries 2
(Date:7/10/2014)... help in the fight against terrorism with the creation ... explosives with the use of light and special glass ... Actuators B: Chemical , the researchers describe a novel ... as low as 6.3 ppm (parts per million). It ... , "Traditionally explosives detection has involved looking for metals ...
(Date:7/10/2014)... Hall effect in bilayer graphene and shown that this ... electric field. , The fractional quantum Hall effect, ... are exposed to large magnetic fields, is a striking ... behave as a single system. However, while the basic ... of this collective behavior remain not well understood, in ...
(Date:7/10/2014)... the University of Illinois at Urbana-Champaign provides new ... of spin and heat at the nanoscale, and ... for data storage and information processing. , ... momentum. In a typical charge current, electrons, spin-angular-momentum ... explained David Cahill, a professor of materials science ...
(Date:1/15/2014)... Automotive, a group of car dealerships headquartered in ... Center and offering free oil change coupons for participation in ... 18 at the Bill Jacobs Cadillac and Chevrolet location from ... )  The Bill Jacobs Auto annual blood ...
Breaking Biology Technology:Detecting trace amounts of explosives with light 2Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3University of Illinois study advances limits for ultrafast nano-devices 2Join the Bill Jacobs Auto blood drive and receive a free oil change 2
... Sept. 28 Idenix,Pharmaceuticals, Inc. (Nasdaq: ... discovery and development of drugs for the ... strategic restructuring. As part of the,restructuring, Idenix ... AG related to Tyzeka(R)/Sebivo(R). Per the amended ...
... the innovator and leader of BioZ(R) Impedance Cardiography ... clearance from,the U.S. Food and Drug Administration (FDA) ... (EMR) interface capability for its BioZ Dx,System. The ... partnership between,the Company and Philips Medical Systems that ...
... Class Action Settlement, NORCROSS, Ga., Sept. ... the global leader in providing automated instrument-reagent,systems ... that the,Securities and Exchange Commission (SEC) has ... investigation into certain,activities involving the company,s Italian ...
Cached Biology Technology:Idenix Pharmaceuticals Restructures to Concentrate Efforts on HCV and HIV Programs 2Idenix Pharmaceuticals Restructures to Concentrate Efforts on HCV and HIV Programs 3Idenix Pharmaceuticals Restructures to Concentrate Efforts on HCV and HIV Programs 4CardioDynamics Receives FDA 510(k) Clearance for Innovative Clinical Parameters and Electronic Medical Record Compatibility 2CardioDynamics Receives FDA 510(k) Clearance for Innovative Clinical Parameters and Electronic Medical Record Compatibility 3Immucor Settles SEC Investigation 2
Mouse monoclonal to Casein Kinase 2 beta ( Abpromise for all tested applications). entrezGeneID: 1460 SwissProtID: P13862...
Alpha-2-antiplasmin precursor (Alpha-2-plasmin inhibitor) (Alpha-2-PI) (Alpha-2-AP). [Source:Uniprot/SWISSPROT;Acc:P08697] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
... monoclonal [HDAC8-48] to HDAC8 Regulation ... several mechanisms such as DNA methylation, ... modifications of histones, which include the ... groups of lysine residues present in ...
Mouse monoclonal antibody raised against a partial recombinant AAAS. NCBI Entrez Gene ID = AAAS...
Biology Products: