Navigation Links
Computers close in on protein structure prediction

Rosetta@home lets public participate in structure prediction.

Computers can predict the detailed structure of small proteins nearly as well as experimental methods, at least some of the time, according to new studies by Howard Hughes Medical Institute researchers.

The findings, which were reported in the September 16, 2005, issue of the journal Science, provide a glimmer of hope that scientists eventually may be able to determine the structure of proteins from their genomic sequences, a problem that has seemed insurmountable.

"For more than 40 years, people have known the amino acid sequence of a protein specifies its three-dimensional structure, but no one has been able to translate the sequence into an accurate structure," said senior author David Baker, an HHMI researcher at the University of Washington. "The reason this research is exciting is that we're showing progress in predicting the structure from the sequence. It's not that the problem is solved, but that there is hope."

Proteins are biological machines, and scientists need to determine their structures to understand how the proteins work. Now, scientists determine structures exclusively by measuring the atomic characteristics of proteins in the lab. In contrast, "in this case, we never touched a test tube," Baker said. "We gave it to a computer and said, 'go.'"

In the study, a sophisticated computer program folded 17 short strings of amino acids into 100,000 possible variations. When the researchers compared the best predictions to the actual structures solved earlier by other scientists using experimental techniques, they had the same success rate as the best hitters in major league baseball.

"We achieved almost atomic resolution in structure prediction for about one-third of our benchmark set of small proteins," said first author Philip Bradley, a postdoctoral fellow in Baker's lab. "It is a real step forward to achieve structures that are in some way comp
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3 4

Related biology news :

1. Computers to be used to find blueprint for new influenza drug
2. Computers to save unique type of American red squirrel
3. Chemicals in tattoo inks need closer scrutiny
4. Doctors closer to using gene analysis to help trauma patients
5. Proteomics brings researchers closer to understanding microbes that produce acid mine drainage
6. New results validating Pall prion reduction filter disclosed at ISBT Congress
7. Scientists closer to new cancer detection method
8. Getting close to nature is good for you
9. Scientists observe how a close bond activates the immune system
10. Stroke treatment a step closer after trial
11. Multiple genes permit closely related fish species to mix and match their color vision
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Computers close protein structure prediction

(Date:7/29/2014)... of a stroke is an immensely complex challenge ... as effective therapy. Advancing such knowledge to improve ... focus of research by Sergei Adamovich, associate professor ... faculty more than a decade ago. It is ... from sources such as the National Institutes of ...
(Date:7/29/2014)... (UM SOD) and Medicine (UM SOM) jointly announced ... million grant award from the National Institute of ... Institutes of Health to study the causes, prevention ... which renews a previous $12 million five-year NIAID-funded ... research by studying chlamydial and gonorrheal diseases as ...
(Date:7/29/2014)... two of the major disciplines behind Jurassic Park is ... stunning photographs and unique illustrations. , Fossil Insects, by ... incredible preservation and diversity of fossilised insects from around ... fossils can tell us about the ancient and modern ... the mosquito in Jurassic Park, many of the hundreds ...
Breaking Biology News(10 mins):Continuing the quest for better stroke therapies 2Continuing the quest for better stroke therapies 3University of Maryland Schools of Dentistry and Medicine receive NIH grant 2University of Maryland Schools of Dentistry and Medicine receive NIH grant 3University of Maryland Schools of Dentistry and Medicine receive NIH grant 4Unique images bring fossil insects back to life 2
... widely-used home pesticides, are winding up in California rivers ... food supply of fish and other aquatic animals, according ... of California, Berkeley, and Southern Illinois University (SIU). ... and other insect pests around the home, have been ...
... New Rochelle, NY, February 2, 2010 Videourology is ... peer-reviewed surgical and micro-invasive video demonstrations of the latest ... Videourology is Part B of the respected ... Mary Ann Liebert, Inc. ( www.liebertpub.com ), and is ...
... Stem cell research at the University of California, Riverside is ... new Stem Cell Core Facility (SCCF) a shared facility ... research that ordinarily would not be available in most laboratories. ... had its grand opening on Friday, Jan. 29. More ...
Cached Biology News:Storm runoff and sewage treatment outflow contaminated with household pesticides 2Storm runoff and sewage treatment outflow contaminated with household pesticides 3Groundbreaking Videourology journal launched by Mary Ann Liebert, Inc. 2UC Riverside's new state-of-the-art technology to accelerate stem cell research 2
(Date:7/29/2014)... Oregon , July 29, 2014 ... "Global surgical equipment market (types, applications and geography) - ... Research, Report, Opportunities, Segmentation and Forecast, 2013 - 2020", ... to reach $12.1 billion by 2020 registering a CAGR ... to the breakthrough achieved by the electro surgical devices ...
(Date:7/29/2014)... Hershey, PA & Rockville, MD (PRWEB) July 29, ... Immunomic Therapeutics, Inc. (ITI), a vaccine pioneer in ... the financial services firm Newport Coast Securities, Inc. ... , ITI is commercializing LAMP-vax technology, a breakthrough ... $25B+ vaccines and immunotherapy market. The company exclusively ...
(Date:7/29/2014)... Hill, South Carolina (PRWEB) July 29, 2014 ... with teams of people where cell phone masts or other ... iPhones up to 100 feet away without the need for ... to target longer ranges. , The new app has launched ... of US homes are at very high risk of being ...
(Date:7/29/2014)... 29, 2014 The first product launch ... generation approach to robotics. What sets Droidles completely apart ... technology that allows them to communicate, share code with ... the internet. , “The invention is the system,” said ... Droidles a life of their own, both physically and ...
Breaking Biology Technology:Global Surgical Equipment Market is expected to reach $12.1 billion by 2020 - Allied Market Research 2Global Surgical Equipment Market is expected to reach $12.1 billion by 2020 - Allied Market Research 3Immunomic Therapeutics Engages Newport Coast Securities, Inc. 2Immunomic Therapeutics Engages Newport Coast Securities, Inc. 3DisasterTalk App Could Save Lives as Report Reveals 8% of US Homes at Very High Risk of Natural Disaster 2Droidles, the Social Network of Robots and Open Source Platform for the Internet of Things, Launches for Crowd Funding on IndieGoGo.com 2
... Introduction , ... of all countries. The ability to produce enough crops is essential to the ... they can advance to higher endeavors. , <P,>Uncontrollable ... wind erosion, etc., can be detrimental to the success of a harvest. The ...
... , ... Simultaneously monitoring the levels of relevant metabolites and cell parameters ... FLUOROMAX spectrofluorometer allows the user to monitor up to eight wavelength-pairs ... produce a real-time analysis of unfolding biological processes. , ...
... , Introduction , ... a defective electron-galvanizing (EV) bath line. Because a sensitive ... productivity, quality, and identification of errors, a detailed analytical ... contribute to selecting the best solution. Both downtime and ...
Cached Biology Technology:Food science: increasing crop yields 2Characterizing galvanizing baths 2Characterizing galvanizing baths 3
Prepared in distilled water....
... RiboGreen RNA Quantitation Kit is one ... for the quantitation of RNA in ... 1000-fold more sensitive than absorbance measurements. ... be detected with fluorescence microplate readers ...
Request Info...
Recommend to use at up to 5000X dilutions for cell culture (e.g. Add 1 ul to 1 ml of culture medium.)...
Biology Products: