Navigation Links
Computer simulation hints at new HIV drug target

ermal motion of their atoms. Drug-binding sites that may be closed most of the time can be transiently exposed by an imperceptible atomic shudder. "This 'foot in the door' mechanism of drug binding and action is a relatively new way of thinking about things, arising from the greater appreciation of proteins as dynamic molecular machines," McCammon explained.

The drug cocktails now used in the treatment of HIV infection are referred to under the umbrella term, highly active antiretroviral therapy, or HAART therapy. Current HAART regimens generally include three antiretroviral drugs, usually two nucleoside analogs and either a protease inhibitor or a non-nucleoside reverse-transcriptase inhibitor. This drug regimen has, in some cases, been effective in controlling the progression of disease and prolonging survival. It has succeeded where other therapies have failed because HAART therapy makes it difficult for even a fast-mutating virus like HIV to develop resistance to all of the drugs at once.

But the specter of drug resistance is a real threat to each individual's therapy and to the long-term success of HAART for newly infected people. By one estimate, about 50 percent of patients receiving antiretroviral therapy in the United States harbor HIV viruses that are resistant to at least one of the available drugs. In fact, people with an infection typically have a diverse array of HIV mutants, some of which are resistant to antiviral drugs. Drug-resistant strains of HIV are being found more often in recently infected people, indicating that transmission of resistant strains is occurring at an increased frequency.

As a graduate student in McCammon's lab, Perryman initially set out to put the HIV protease enzyme in motion in a computer simulation, to catalog its many possible configurations. "HIV can wiggle and jiggle and move around into different shapes," he said. "We wanted to generate a bunch of conformations as possible targets for drug desig
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3 4 5

Related biology news :

1. Computers to be used to find blueprint for new influenza drug
2. Large-scale Computer Simulations Reveal New Insights Into Antibiotic Resistance
3. Computers close in on protein structure prediction
4. Computer modeling reveals hidden conversations within cells
5. Computer models aid understanding of antibody-dependent enhancement in spread of dengue fever
6. Computer-chemistry yields new insight into a puzzle of cell division
7. Computers to save unique type of American red squirrel
8. Computer scientist sorts out confusable drug names
9. Computer-based games enhance mental function in patients with Alzheimers
10. Computer scientists unravel language of surgery
11. Computer with brain connections changing quality of life of paralyzed
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Computer simulation hints new HIV drug target

(Date:7/9/2014)... nature,s ability to split the water molecule during ... artificial photosynthesis for clean, green and renewable energy ... scientists led by researchers with the Lawrence Berkeley ... Accelerator Laboratory. , Working at SLAC,s Linac ... x-ray laser, the researchers were able to take ...
(Date:7/9/2014)... about the prevalence of antibiotic-resistant illness, Case Western ... to disabling disease: blocking bacteria,s access to iron ... bacterial siderophore, a small molecule, captures iron from ... as well as how the body launches ... findings appear in a recent edition of ...
(Date:7/9/2014)... first-ever global census of Adlie penguins shows that ... 53 percent larger than previously estimated. Adlie penguins ... to monitor and understand the effects of climate ... By using high-resolution satellite imagery, researchers from Stony ... a new method that permits regular monitoring of ...
Breaking Biology News(10 mins):Postcards from the photosynthetic edge 2Postcards from the photosynthetic edge 3Bacteria hijack plentiful iron supply source to flourish 2New study finds that Adélie penguin population is on the rise 2New study finds that Adélie penguin population is on the rise 3
... researchers report that common assumptions employed in the generation ... can lead to seriously flawed conclusions about gene activity ... biological research. "Expression analysis is one of the ... Member Richard Young. "So we are concerned that flawed ...
... new collaborative project among researchers from Uppsala University in ... first time, demonstrated experimentally the evolutionary force behind the ... of seed beetle. This mechanism is revealed ... Current Biology . The experiments leading to this ...
... PITTSBURGHWhile Omega-3 essential fatty acidsfound in foods like wild ... their effects on the working memory of healthy young ... the first study of its kind, researchers at the ... ages 18-25 can improve their working memory even further ...
Cached Biology News:Whitehead scientists identify major flaw in standard approach to global gene expression analysis 2Size does matter in sexual selection, at least among beetles 2Omega-3 intake heightens working memory in healthy young adults 2Omega-3 intake heightens working memory in healthy young adults 3
(Date:1/15/2014)... January 15, 2014 DTS Language Services, ... Online Web Portal for Life Science organizations who need document ... the subject matter of their documents in advance with a ... reduce time-to-delivery of translations, often a critical factor in clinical ...
(Date:1/14/2014)... 2014 Date: Friday, April 11, 2014 , ... Club, 1360 Almshouse Road, Warrington, Pa. , Details: ... dedicated to finding a cure for hepatitis B and improving ... its annual Crystal Ball on Friday, April 11 at Warrington ...
(Date:1/14/2014)... 14, 2014 EquitiesIQ, a leading informational ... ALQA). Alliqua is an emerging biomedical company acquiring, developing, ... care market. , Free report download: http://equitiesiq.com/reports/alliqua/ ... seasoned management team and Board, which launched the company’s ...
(Date:1/14/2014)... , Jan. 14, 2014  RXi Pharmaceuticals Corporation ... developing and commercializing innovative therapies addressing major unmet ... it received the Notice of Allowance from the ... unique self-delivering RNAi compounds (sd-rxRNA®), for the treatment ...
Breaking Biology Technology:DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3
... Sequenom, Inc. (NASDAQ: SQNM ), a ... announced the acceptance for publication of the manuscript, "Clinical ... of Developing Choroidal Neovascular Age-related Macular Degeneration." The article ... Genomics . The study, conducted by the company,s wholly-owned ...
... who design new materials often struggle to understand ... including polymers and biological materials change upon cooling ... a tar-like consistency at intermediate temperatures, then become ... lower temperatures. Scientists have long sought a molecular-level ...
... Researchers at Northwestern University have created a new ... invisible in the terahertz range. Though this ... the visible spectrum, it could have implications in ... by Cheng Sun, assistant professor of mechanical engineering ...
Cached Biology Technology:Sequenom Announces Publication Acceptance of Manuscript From Age-related Macular Degeneration Validation Study 2Sequenom Announces Publication Acceptance of Manuscript From Age-related Macular Degeneration Validation Study 3Sequenom Announces Publication Acceptance of Manuscript From Age-related Macular Degeneration Validation Study 4Sequenom Announces Publication Acceptance of Manuscript From Age-related Macular Degeneration Validation Study 5Sequenom Announces Publication Acceptance of Manuscript From Age-related Macular Degeneration Validation Study 6Understanding how glasses 'relax' provides some relief for manufacturers 2Researchers create terahertz invisibility cloak 2
AM100 is an aqueous-based, permanent mounting media designed for use with alkaline phosphatase and immunoperoxidase stained tissue sections....
...
... Fixation Buffer, used in conjunction with ... can be used to fix and ... staining of cytokines and other cytoplasmic ... been specially formulated for reducing non-specific ...
... polyclonal to JMJD2D ( Abpromise for ... Synthetic peptide conjugated to KLH derived ... Human JMJD2D.(Note: the amino acid sequence is ... Entrez Gene ID: 55693 ...
Biology Products: