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Computer models aid understanding of antibody-dependent enhancement in spread of dengue fever

body-dependent enhancement creates oscillations, or "booms and busts" in the incidence of dengue virus infections. Enhancement results in larger booms, but also deeper troughs in incidence, which lead to extinction. Although the computer models were specifically developed for dengue, the researchers believe the results could apply to any disease in which partial immunity increases pathogen replication rates.

"Experimental dengue vaccines will soon be entering into large-scale clinical trials. We must understand the processes that affect transmission--such as antibody-dependent enhancement--to design optimal dengue vaccination strategies," said Donald S. Burke, MD, senior author of the study and professor in the Department of International Health at the Bloomberg School.

"Dynamic effects of antibody-dependent enhancement on the fitness of viruses" was written by Derek A. T. Cummings, Ira B. Schwartz, Lora Billings, Leah B. Shaw and Donald S. Burke. Cummings and Burke are with the Johns Hopkins Bloomberg School of Public Health. Schwartz and Shaw are with the Naval Research Laboratory, Washington, D.C., and Billings is with Montclair State University.


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Source:Johns Hopkins University Bloomberg School of Public Health


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