Navigation Links
Computational verification of protein-protein interactions by orthologous co-expression

In the March 3 issue of Nature, Johns Hopkins researchers report that two proteins best known for very different activities actually come together to turn the liver into a sugar-producing factory when food is scarce. Because the liver's production of sugar is a damaging problem in people with diabetes, the proteins' interaction might be a target for future drugs to fight the disease, the researchers say.

Under normal circumstances, the liver's production of sugar is a back-up plan that enables survival during food shortages; the brain and certain other critical organs rely on sugar -- specifically glucose -- for the energy to function. In people with diabetes, however, the liver doesn't sense the incoming calories, and it keeps making glucose when it shouldn't.

The researchers discovered that, in fasting mice, the liver's production of sugar kicked into high gear because amounts and activities of the two proteins, called sirtuin1 and PGC1-alpha, increased when dietary calories weren't available. Once mice were fed, levels of the two proteins went down and sugar production ceased.

"It isn't a coincidence," says Pere Puigserver, Ph.D., an assistant professor of cell biology at the Johns Hopkins University School of Medicine's Institute for Basic Biomedical Sciences. "The two proteins actually bind to each other, and without sirtuin1, PGC1 can't make glucose."

A current diabetes-fighting drug, metformin, blocks steps in the glucose-making process, but the new research identifies a critical regulatory step the researchers say could be targeted as well.

PGC1, which Puigserver isolated and cloned in 1998 as a postdoctoral fellow at Harvard, controls gene expression in the liver and other tissues. In the liver, it triggers the conversion of fats into sugar, particularly when access to food is limited. But no one knew exactly how it was controlled or what else it might need in order to launch the sugar-making process.

Sirtuin1,
'"/>

Source:


Page: 1 2 3

Related biology news :

1. Supercomputer Dedicated To Bioengineering, Computational Biology Installed
2. Institute for Systems Biology Symposium Addresses Need for Better Computational Tools
3. Computational Method Speeds Mapping of Cell Signaling Networks
4. Computational Tool Predicts How Drugs Work In Cells, Advancing Efforts To Design Better Medicines
5. Computational model simulates AZT metabolism in mitochondria
6. Computational analysis shows that plant hormones often go it alone
7. Virus-host interactions at sea effect global photosynthesis
8. Complex gene interactions account for autism risk
9. A real time look at interactions between RNA and proteins
10. U of MN researchers develop way to visualize synchronized interactions of nerve cells in the brain
11. Biologists develop genome-wide map of miRNA-mRNA interactions
Post Your Comments:
(Date:10/29/2014)... held in New York City on September 19, 2014, ... Cancer Society Professor of Genome Sciences and Medicine at ... Doctor of Philosophy of Tel Aviv University, was awarded ... , In addition to her honorary degree from TAU, ... TAU School of Medicine, and for the past 18 ...
(Date:10/29/2014)... is available in German . ... Gabriela Cabral and Peter Schlögelhofer at the Max F. ... the Medical University of Vienna dived into the process ... these plants display an inversion of the standard meiotic ... scientific journal Nature Communications . , Meiosis is ...
(Date:10/29/2014)... of the Barcode of Life Data Systems ... Biodiversity Data Journal (BDJ) used specimen records ... into a human-readable text developed in manuscript within the ... to study the species distributions of ten Nearctic species ... is originally designed to support the generation and application ...
Breaking Biology News(10 mins):Geneticist and humanitarian: Prof. Mary-Claire King receives Lasker Award 2Meiotic cell division 'the other way round' 2Go straight and publish: From Barcode of Life Data Systems to scholarly publishing systems 2
... is a key requirement for good health and alternative cheap, ... that has just been published in the leading American Chemical ... University in co-operation with The University of Botswana describe how ... used for water purification. Flocculation of particulate impurities ...
... A rapid and unprecedented proliferation of oil and gas ... area leased is on track to reach around 70% ... is one of the central conclusions from a pair ... Ambientals (ICTA) of Universitat Autnoma de Barcelona (UAB), and ...
... for the Advancement of Science (AAAS) meeting is being ... will be presenting on topics ranging from linear colliders ... Also occurring at the end of this year,s ... as the next president of the AAAS. Below is ...
Cached Biology News:Seeds from the Moringa tree can be used for water purification 2A second hydrocarbon boom threatens the Peruvian Amazon 2A second hydrocarbon boom threatens the Peruvian Amazon 3Caltech researchers presenting at AAAS Meeting 2Caltech researchers presenting at AAAS Meeting 3Caltech researchers presenting at AAAS Meeting 4Caltech researchers presenting at AAAS Meeting 5Caltech researchers presenting at AAAS Meeting 6
(Date:10/30/2014)... Dallas, Texas (PRWEB) October 30, 2014 ... China Naltrexone HCL Industry” is a professional and ... The report provides basic Naltrexone HCL information, including ... as well as industry overview. This research covers ... as well as global industry analysis covering macroeconomic ...
(Date:10/30/2014)... Spartan Bioscience announced today that Health Canada has ... detects CYP2C19 genetic mutations in less than 60 minutes ... CYP2C19 System is the first near-patient DNA test for ... to the system’s ease of use, Health Canada has ... such as doctors, nurses, pharmacists, and laboratory technicians, in ...
(Date:10/30/2014)... Oct. 30, 2014 A new report, commissioned ... Practice, takes an in-depth look at Indiana,s ... have resulted over two different time frames: 1993 to ... view of future opportunities for investment growth.  The ... report shows gains in innovation dollars as well ...
(Date:10/27/2014)... (PRWEB) October 27, 2014 The ... by Type (High & Medium), Sub-type (Primary & ... Processing, Infrastructure & Transportation & Power Generation) - ... the GIS market with analysis and forecasting of ... Market Data Tables with 52 Figures spread through ...
Breaking Biology Technology:Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 2Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 3Health Canada approves first near-patient DNA test for personalized medicine 2Health Canada approves first near-patient DNA test for personalized medicine 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 2New report shows Indiana's gains in life sciences innovation capital outpace the nation 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 4New report shows Indiana's gains in life sciences innovation capital outpace the nation 5Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 2Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 3Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 4
... Prize, Draper Laboratory, in conjunction with the National Academy of Engineering ... learn about the impact engineers have had on our daily lives, ... been awarded "Engineering,s Nobel" since 1989. , ... Cambridge, ...
... Inc.,(Nasdaq: PCYC ), a developmental stage biopharmaceutical ... late stage preclinical programs,announced today the appointment of a ... Robert W. Duggan, our Chairman of ... acting as interim CEO for the past five months. ...
... Savient Pharmaceuticals, Inc. (Nasdaq: SVNT ) today ... position of Vice President, Chief Financial Officer & Treasurer. ... terminated as Savient,s Chief Financial Officer, effective immediately. ... our current Vice President of Corporate Finance and Controller, ...
Cached Biology Technology:New Educational Website Celebrates the Accomplishments of Engineers 2Pharmacyclics Announces Appointment of New Management Team and Board Director to Accelerate Its Future Growth 2Pharmacyclics Announces Appointment of New Management Team and Board Director to Accelerate Its Future Growth 3Pharmacyclics Announces Appointment of New Management Team and Board Director to Accelerate Its Future Growth 4Pharmacyclics Announces Appointment of New Management Team and Board Director to Accelerate Its Future Growth 5Pharmacyclics Announces Appointment of New Management Team and Board Director to Accelerate Its Future Growth 6Savient Announces Appointment of David Gionco as Chief Financial Officer 2Savient Announces Appointment of David Gionco as Chief Financial Officer 3Savient Announces Appointment of David Gionco as Chief Financial Officer 4
... Buffer is a concentrated formulation of a ... capillary action technology, as well as for ... with David Brigati M.D., Department of Pathology, ... buffer is recommended for all the rinsing ...
...
... Intended for users requiring mass detection ... linear MALDI TOF Mass spectrometer is ... applications and for high performance mass ... QA/QC, SNP analysis, protein detection, micro-satellite ...
Rat Aortic Smooth Muscle Cells (RAOSMC) (>500,000 cells)...
Biology Products: