Navigation Links
Computational Method Speeds Mapping of Cell Signaling Networks

For decades, scientists have been studying how external information gets transmitted from outside of cells to the control centers inside them that trigger particular responses. But cell signaling networks are so complex that mapping them has been a slow, arduous process.

Now, a research team from Stanford, MIT and Harvard has developed a new method for charting cellular signaling networks quickly and accurately. Their findings appear in the April 22 issue of Science.

To function properly, cells must be able to detect changes in the environment and respond accordingly--usually by altering their behavior in some way. Cells are equipped with a sophisticated communications network that links surveillance with response, and allows the cells to perform a variety of tasks--such as growing in response to hormones, moving towards a source of nutrients, or responding to foreign invaders in the body. In all of these cases, external signals are converted into cellular messages that get passed sequentially from one molecule to another. Tracing the individual pathways that guide information flow inside cells is a difficult task using standard experimental methods. Multidisciplinary research teams are working on new approaches to make the process faster and easier.

One such group, led by Garry Nolan of Stanford University and Douglas Lauffenburger of MIT has "opened the door for systematic mapping of signaling pathways," according to team member Dana Pe'er. They tested their technique--a combined approach of state-of-the-art experimental and computational methods that "fit like a hand in a glove,"--by mapping a well-studied signaling network in human immune system T-cells. This feat originally took researchers decades to accomplish using traditional approaches.

In the past, scientists have treated signal networks like a puzzle--studying them one pathway at a time and then tying the information together to construct a global picture of what’s going on
'"/>

Source:NSF


Page: 1 2 3

Related biology news :

1. Supercomputer Dedicated To Bioengineering, Computational Biology Installed
2. Institute for Systems Biology Symposium Addresses Need for Better Computational Tools
3. Computational verification of protein-protein interactions by orthologous co-expression
4. Computational Tool Predicts How Drugs Work In Cells, Advancing Efforts To Design Better Medicines
5. Computational model simulates AZT metabolism in mitochondria
6. Computational analysis shows that plant hormones often go it alone
7. New Mixing Method for Microchip-Sized Labs
8. Method slashes quantum dot costs by 80 percent
9. Mapping neuron connections in the brain
10. Mapping alcohol brain damage
11. Mapping the protein world
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Computational Method Speeds Mapping Cell Signaling Networks

(Date:7/25/2014)... Canadian wildfires have been raging this summer and some of ... U.S. In this image collected by the Moderate Resolution ... 2014 a swath of smoke has descended over the Great ... interesting is the fire image from July 23, 2014 (first ... smoke as it drifts off southeastward. In the image, ...
(Date:7/25/2014)... Birla, associate professor of biomedical engineering at the ... on tissue engineering and artificial organ development., "Introduction ... comprehensive guide to entering into the field of ... professor of biomedical engineering at UH, served as ... that while there are other published books on ...
(Date:7/25/2014)... Spina bifda (SB) is a complex congenital central ... incomplete closing of the neural tubes during the ... spasticity, urinary and fecal incontinence and neurocognitive retardation. ... their quality of life. Researchers at Ankara Physical ... investigate the functional performance in children with SB, ...
Breaking Biology News(10 mins):University of Houston researcher publishes textbook on tissue engineering 2
... scientific studies of the effects on wildlife of large-scale ... assess their impact, especially in the desert Southwest, according ... Geological Survey and published in the journal BioScience ... the paper, USGS scientist Jeffrey Lovich and Maryville College ...
... oil spill in the Gulf of Mexico, the U.S. ... Engineering and National Research Council to convene a committee ... disaster and identify measures for preventing similar harm in ... IMPROVING OFFSHORE DRILLING SAFETY, the committee,s final report, analyzes ...
... believe decision making mechanisms in the human brain could mirror ... similarities have been found in decision making systems between humans ... bees could teach us about how our brains work. ... an often paralysing thought process in humans, with scouts who ...
Cached Biology News:Literature review on solar energy and wildlife impacts research 2Swarms of bees could unlock secrets to human brains 2
(Date:7/24/2014)... 24, 2014 -- A novel combination of microscopy and ... Energy,s Oak Ridge National Laboratory an unprecedented look at ... physical and electrochemical properties. , The research team ... the surface of a perovskite manganite, a complex material ... avenue to understand surface behavior could benefit researchers who ...
(Date:7/24/2014)... 24, 2014  Now available is a stem cell ... Regenerative Therapies , located in Guadalajara, Mexico ... people a new health option: stem cell therapies ... countless patients suffer from joint and muscle injuries due ... tears, torn rotator cuff, tennis elbow, and knee injuries. ...
(Date:7/24/2014)... Calif. , July 24, 2014  ECC West ... Denver, Colorado with University College Hospital (UCH) ... a development project to finance, design, construct, and operate ... Nigeria . Under the first of ... prepare scoping documents and funding applications. UCH Ibadan intends ...
(Date:7/24/2014)... A research team led by group leader Yung-Eun ... technology to synthesize sulfur-doped and nitrogen-doped graphenes which ... secondary batteries and fuel cells. Yung-Eun Sung is ... Nanoparticle Research at Institute for Basic Science* (IBS) ... , This achievement has great significance with regards ...
Breaking Biology Technology:ORNL study reveals new characteristics of complex oxide surfaces 2Stem Cells In Sports Injuries, Joints And Muscular Pain 2Stem Cells In Sports Injuries, Joints And Muscular Pain 3ECC Signs a Contract for the Finance, Design, and Construction of a Premier Cancer Institute in Ibadan, Nigeria 2
... present the 2011 "ALBERT EINSTEIN" World Award of Science ... Distinguished University Professor University of Toronto, Canada. ... Ozin as the winner of the 2011 "ALBERT EINSTEIN" ... the field of nanochemistry that have helped to define ...
... Pharmaceuticals, Inc. (Nasdaq: ANDS ) is updating the ... Nicolaus Healthcare Conference to Thursday, September 8, 2011 at 4:25 ... at the Four Seasons Hotel in Boston.  Steve Worland, Ph.D., ... overview of Anadys and its clinical development programs, setrobuvir and ...
... ALCLS), the French genome engineering specialist, will present at the UBS ... 2011, and at the MidCap Event in Paris on September 22 ... the activities and the development strategy of the Cellectis group at ... York hotel on Tuesday, September 20, 2011 at 11:30 am ET. ...
Cached Biology Technology:2011 Awards of World Cultural Council 22011 Awards of World Cultural Council 32011 Awards of World Cultural Council 42011 Awards of World Cultural Council 5Anadys Pharmaceuticals Updates Its Presentation Date at the Stifel Nicolaus Healthcare Conference 2
Can be used for the quantitative recovery of small amounts of nucleic acids within dilute solutions. 5mg/ml...
APOPTAG® Plastic Coverslips are designed to be custom fitted to the specific APOPTAG® kit application. Each coverslip has 2.5 x 1 dimensions....
Human VEGF-D Biotinylated MAb (Clone 78923)...
Recombinant Mouse TGF-beta RII/(human) Fc Chimera, CF...
Biology Products: