Navigation Links
Compound in dairy products targets diabetes

Fatty acids commonly found in dairy products have successfully treated diabetes in mice, according to a researcher at Penn State. The compounds, known as conjugated linoleic acids (CLA), have also shown promising results in human trials, signaling a new way of potentially treating the disease without synthetic drugs.

"The compounds are predominantly found in dairy products such as milk, cheese and meat, and are formed by bacteria in ruminants that take linoleic acids ?fatty acids from plants ?and convert them into conjugated linoleic acids, or CLA," says Jack Vanden Heuvel, professor of molecular toxicology in Penn State's College of Agricultural Sciences and co-director of Penn State's Center of Excellence in Nutrigenomics.

Researchers first became interested in CLA when it was shown to inhibit a variety of cancers such as breast, skin and colon in mice, and further research showed effects on circulating cholesterol and inflammation. These effects are the same as the newest generation of synthetic drugs used to treat diabetes in humans.

These synthetic drugs act by triggering a set of nuclear receptors called PPAR. In addition to being targets for a variety of clinically effective drugs, PPARs belong to a large family of proteins, and their biological purpose is to sense fatty acids and fatty acid metabolites within the cell, says Vanden Heuvel.

When the synthetic drugs interact with these protein receptors, it turns the receptor "on," making it an active form of the protein, which then interacts with DNA and regulates gene expression. This increases the enzymes that process fatty acids and also increases the tissues' sensitivity to insulin.

"We wondered if CLA was using the same mechanism, in which case it could be used as an anti-diabetes drug," Vanden Heuvel says.

To test the idea, he used CLA on mice prone to adult onset (Type-2) diabetes. Results indicated that the mice had an improvement in in
'"/>

Source:Penn State


Page: 1 2

Related biology news :

1. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
2. Newly Discovered Compound Blocks Known Cancer-Causing Protein
3. Compounds in plastic packaging act as environmental estrogens altering breast genes
4. Compound might defeat African sleeping sickness, clinical trial beginning this month
5. Compound from Chinese medicine shows promise in head and neck cancer
6. Anti-cancer Compound In Beer Gaining Interest
7. Compound from marine bacteria shows potential as multiple myeloma therapy
8. Compound eyes, evolutionary ties
9. Drug-resistant bacteria on poultry products differ by brand
10. Component in soy products causes reproductive problems in laboratory mice
11. In presence of fragrant cleaning products, air purifiers that emit ozone can dirty the air
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Compound dairy products targets diabetes

(Date:8/20/2014)... 20, 2014) Women who are poor experience higher ... with elevated levels of the stress hormone, putting ... life, according to a new research from the University ... in the American Journal of Human Biology , ... relate it directly to the socioeconomic status of their ...
(Date:8/20/2014)... Carolina State University researchers have developed methods for electronically ... the electrical signals moths use to control those muscles. ... remotely-controlled moths, or "biobots," for use in emergency response. ... whether we can control the movement of moths for ... says Dr. Alper Bozkurt, an assistant professor of electrical ...
(Date:8/20/2014)... DENVER , Aug. 20, 2014  The ... take place in Tampa, Florida ... interactive sessions with Steven Rahman, Director, Technology and Strategy ... Sector at Experian. The theme of this year,s ... and Privacy. "Biometrics UnPlugged: Mobility ...
Breaking Biology News(10 mins):CU Denver researcher shows economic disparities impact infant health 2Research paves way for development of cyborg moth 'biobots' 2Biometrics UnPlugged: Mobility at the Crossroads of Commerce & Privacy to Feature Interactive Sessions with Samsung and Experian 2
... major component of soy, was found to disrupt the ... were given the product. This study adds to a ... of genistein on the reproductive system. , "Although we ... on genistein translate to the human population, there is ...
... and it becomes harder to balance home and work, many ... sleep deprivation impairs spatial learning -- including remembering how to ... to understand how that happens: Learning spatial tasks increases the ... involved with spatial memory called the hippocampus. Sleep plays a ...
... do an animal's senses change as it evolves to ... system of the fruit fly Drosophila melanogaster, which feeds ... species D. sechellia, a specialist particularly drawn to a ... act on several different levels of a sensory system ...
Cached Biology News:Component in soy products causes reproductive problems in laboratory mice 2Losing sleep undoes the rejuvenating effects new learning has on the brain 2Losing sleep undoes the rejuvenating effects new learning has on the brain 3Losing sleep undoes the rejuvenating effects new learning has on the brain 4Losing sleep undoes the rejuvenating effects new learning has on the brain 5Evolutionary shifts in olfactory sensitivities in fruit flies 2
(Date:8/19/2014)... Jolla, CA (PRWEB) August 19, 2014 ... toll Parkinson’s disease can take on an individual. ... extremities, decreased facial expression, problems swallowing and severe depression. ... to the dying off of dopamine producing neurons of ... themselves from a disease that slowly and progressively gets ...
(Date:8/19/2014)... 19, 2014 CSSi, the leader in patient ... the formation of the company,s Medical and Clinical Advisory ... of Dr. William E. Gannon, Jr. to ... The MCAB, with Dr. Gannon,s leadership, ... areas and set strategic goals for the advancement and ...
(Date:8/19/2014)... 2014 /PRNewswire/ - iCo Therapeutics Inc. ("iCo" or "the ... of its Oral Amphotericin B (Oral Amp B) ... conducted by ImmuneCarta®, the immune monitoring business unit ... of Oral Amp B in reactivating latent HIV ... intensive treatment with antiretroviral therapy. ...
(Date:8/18/2014)... 2014) -- A new therapy developed by researchers ... College of Medicine and Columbia University Medical Center ... interventional cardiovascular disease treatment. , The researchers ... molecular therapy could selectively inhibit blood vessel re-narrowing ... procedure using a balloon catheter to open narrowed ...
Breaking Biology Technology:As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 2As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 3CSSi Appoints Dr. William E. Gannon, Jr. to Newly Formed Medical and Clinical Advisory Board 2CSSi Appoints Dr. William E. Gannon, Jr. to Newly Formed Medical and Clinical Advisory Board 3iCo Therapeutics Announces Positive Oral Amphotericin B Study Results 2iCo Therapeutics Announces Positive Oral Amphotericin B Study Results 3Selective therapy may improve artery repair after interventional cardiovascular procedures 2Selective therapy may improve artery repair after interventional cardiovascular procedures 3
... 19 /Xinhua-PRNewswire/ -- Shanghai Century (Amex:,SHA), a special ... Co., Ltd (Kelun), China,s largest producer of,intravenous (IV) ... highlights with respect to the consolidated results of,operations ... entity,(Kelun Group) for the first half of 2007. ...
... With the Middle Class Using India,s Private Health Care ... be an Increasing Need for Diagnostic Imaging ... Group,forecasts that growing demand for private health care in ... As a result, the,market will experience rapid growth, reaching ...
... to Accurately Measure Cardiac Output ... Testing (CPX), WASHINGTON, September 19 Cheetah Medical Inc.,developers ... announced at HFSA the results of the study,"Markers of ventilatory ... study, led by Dr. Jon Myers of Stanford University and ...
Cached Biology Technology:Shanghai Century Acquisition Corporation Announces Sichuan Kelun Pharmaceutical Co Results for the Six Months Ended June 30, 2007 2Shanghai Century Acquisition Corporation Announces Sichuan Kelun Pharmaceutical Co Results for the Six Months Ended June 30, 2007 3Shanghai Century Acquisition Corporation Announces Sichuan Kelun Pharmaceutical Co Results for the Six Months Ended June 30, 2007 4Shanghai Century Acquisition Corporation Announces Sichuan Kelun Pharmaceutical Co Results for the Six Months Ended June 30, 2007 5Not Just for the Rich: India's Private Health Care is Booming 2Cheetah Medical's NICOM Non-Invasive Cardiac Output Monitor Featured in a Presentation at the Heart Failure Society of America (HFSA) Annual Meeting 2Cheetah Medical's NICOM Non-Invasive Cardiac Output Monitor Featured in a Presentation at the Heart Failure Society of America (HFSA) Annual Meeting 3
... by R. Edwards (1996) • ... types of immunoassays, including RIA, ... and on the photoluminescent and ... information is also given on ...
ANTI S. ENTERID LPS...
B.D. Hames and D.M. Glover (1996) • This issue covers T-Cell antigen receptor genes; T-Lymphocyte signal transduction; B-Cell activation antibody engineering and the complement system and other ...
Request Info...
Biology Products: