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Complexity constrains evolution of human brain genes

is of individual neurons of the brain, humans may indeed have a far more active, or even more complex, transcription profile than chimpanzee," the authors note. "We suggest that such abundant and complex transcription may increase gene-gene interactions and constrains coding-sequence evolution."

Future studies of brain function and evolution will increasingly take advantage of the approaches of systems biology, Wu suggested. "The slowdown in genetic evolution in the more advanced organs makes sense," he said, "only when one takes a systems perspective."
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Source:University of Chicago Medical Center


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