Navigation Links
Complex gene interactions account for autism risk

cs (available online August 3, 2005). The work was supported by the National Institutes of Health, the National Alliance of Autism Research, and the Hussman Foundation. Resources were also provided by The Autism Genetic Resource Exchange, a program of Cure Autism Now.

In recent years, the number of children diagnosed with autism in the United States has skyrocketed, the researchers noted. One of the most heritable of complex genetic disorders in neuropsychiatry, autism is characterized by impairments in social interaction and communication and restricted and repetitive patterns of interest or behavior.

While many previous studies have identified possible genes with links to autism, there remains no single gene with a consistent connection to the disease, Pericak-Vance said.

Multiple lines of evidence, including alterations in levels of GABA and GABA receptors in patients with autism, have implicated the brain mechanism in the disease. Furthermore, there is evidence that GABA plays a key role in the early development of the brain.

Earlier research by the Duke team and other researchers linked a portion of chromosome 15 to autism risk. That region harbors genes that code for three GABA receptors.

Since one of the primary functions of GABA is to inhibit nerve cells from firing, it plays a key role in telling the body to "slow down.". The GABA system therefore acts as a sort of information filter, preventing the brain from becoming over-stimulated, the researchers explained.

"Impairing the GABA system could overwhelm the brain with sensory information, leading to both the behavior and the pattern of cell damage that emerges in autism," said John Hussman, Ph.D., a study co-author and president of The Hussman Foundation, one of the groups that funded the study.

The researchers examined 14 genes that encode portions of the GABA receptor in 470 Caucasian families. Of those families, 266 included more than one person wi
'"/>

Source:Duke University Medical Center


Page: 1 2 3

Related biology news :

1. Complexity constrains evolution of human brain genes
2. Virus-host interactions at sea effect global photosynthesis
3. Computational verification of protein-protein interactions by orthologous co-expression
4. A real time look at interactions between RNA and proteins
5. U of MN researchers develop way to visualize synchronized interactions of nerve cells in the brain
6. Biologists develop genome-wide map of miRNA-mRNA interactions
7. APS lecturer shows rare video of teacher-student immune cell interactions in live animal
8. Small molecule interactions were central to the origin of life
9. New book expands biological classifications to account for alien life
10. Hepatitis B accounts for 40 percent of missing Asian women
11. Primates take weather into account when searching for fruits
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Complex gene interactions account for autism risk

(Date:11/11/2014)... 11, 2014  Forensicon, Inc., a Chicago ... to announce the promotion of Yaniv Schiff ... Forensics. In Schiff,s new role as Director, he will ... digital forensics examiners and provide leadership within the company,s ... http://photos.prnewswire.com/prnh/20141110/157719 Schiff joined Forensicon ...
(Date:11/6/2014)... A groundbreaking paper from a team of Florida State ... how plants could adapt to and survive environmental swings ... in the latest issue of the journal The ... complex of DNA and proteins) is organized in a ... some genes are turned on and others are turned ...
(Date:11/5/2014)... career to understanding the Earth,s climate and communicating ... deputy director and regional climatologist for the Western ... Redmond has more than three decades of experience ... data to the general public. , At its ... December 15-19, 2014 the American Geophysical Union (AGU) ...
Breaking Biology News(10 mins):Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2Maize analysis yields whole new world of genetic science 2Nevada climatologist to be honored at AGU Fall Meeting for lifetime of public outreach 2
... Foundation (NSF) has awarded $50 million to a multi-institution ... to create a national cyberinfrastructure for the biological sciences. ... with partner sites at the Texas Advanced Computing Center ... Harbor Laboratory (CSHL) in New York, and University of ...
... biochemical signals can guide cells to make, for example, muscle, ... the desired tissues have proved elusive. Now, researchers at ... that mix by developing an easy and versatile way of ... one of their goals is to engineer systems to manipulate ...
... Spaniards to bask in regions like the Costa del Sol ... protect their paler skin or risk skin cancer is due ... MC1R gene locus. The MC1R gene, expressed in skin and ... to African populations. Now, a team of researchers led ...
Cached Biology News:$50 million NSF grant to advance cyberinfrastructure for big data in life sciences 2$50 million NSF grant to advance cyberinfrastructure for big data in life sciences 3$50 million NSF grant to advance cyberinfrastructure for big data in life sciences 4Signal gradients in 3-D guide stem cell behavior 2Signal gradients in 3-D guide stem cell behavior 3Evolutionary medicine of skin cancer risk among Europeans 2
(Date:11/18/2014)... pH measurement and control is vital in ... and food and beverage industries. But what exactly is ... pH sensors work? METTLER TOLEDO has produced a guide ... with these questions and more. , METTLER TOLEDO provides ... industries. The actual sensor, the pH electrode, is therefore ...
(Date:11/18/2014)... Brunswick, NJ (PRWEB) November 18, 2014 ... Data Quality and Transparency Reporting solutions, announced today ... gone live using its Consummate Providerâ„¢ solution in ... Providerâ„¢ is a Global, SaaS based, Data Quality ... organizations and their third party Providers improve their ...
(Date:11/18/2014)... Lauderdale, FL (PRWEB) November 18, 2014 ... have announced the launch of PAWSitively Curing Cancer, ... Month. This new 501(c) (3) non-profit organization is dedicated ... dollar donated goes directly to the University of ... to partner with PAWSitively Curing Cancer as the recipient ...
(Date:11/18/2014)... Array Architects is proud of a ... the nation's hospitals and health systems. It is a ... their careers to the advancement of both the healthcare ... respective field, Laura Silvoy has been chosen to share ... Simulation Conference. , Laura will present her Process ...
Breaking Biology Technology:pH Guide from METTLER TOLEDO Explains Measurement, Theory and Practice of pH Applications 2Alanda Software Completes Successful Implementation of Global Data Quality & Vendor Management Solution for Top Tier Global Biopharmaceutical Company 2PAWSitively Curing Cancer, Inc. Launched By Two Children for National Pet Cancer Awareness Month 2PAWSitively Curing Cancer, Inc. Launched By Two Children for National Pet Cancer Awareness Month 3Array Healthcare Simulation Expert Slated to Speak at Winter Simulation Conference 2
... ... control products, introduces CapSure™ Technology, advancing the performance of cleanroom wipers on particle ... ... a manufacturer of contamination control products for cleanroom and critical environments, introduces CapSure™, ...
... (NYSE: CRY ) an implantable biological medical ... has received a Humanitarian Use Device (HUD) designation from the ... human heart valve. The HUD designation is the first ... CryoValve SG aortic human heart valve, which is processed with ...
... Novavax, Inc. (Nasdaq: NVAX ) a clinical-stage vaccine ... of Novavax, will be making two presentations at the World ... Palais des Congres de Lyon, Lyon, France. The first ... development and VLP based vaccines, will be presented under the ...
Cached Biology Technology:New CapSure™ Cleanroom Wiper from Berkshire Corporation Captures and Retains 42 Times More Contaminant Particles 2CryoLife Receives Humanitarian Use Device Designation for SynerGraft(R) Processed Human Aortic Heart Valves 2CryoLife Receives Humanitarian Use Device Designation for SynerGraft(R) Processed Human Aortic Heart Valves 3CryoLife Receives Humanitarian Use Device Designation for SynerGraft(R) Processed Human Aortic Heart Valves 4
Mouse monoclonal [RL13] to LAP1 ( Abpromise for all tested applications). SwissProtID: Q96NW7...
Rabbit polyclonal to ECSIT ( Abpromise for all tested applications). entrezGeneID: 51295 SwissProtID: Q96HQ7...
... Antigen peptide transporter ... TAP2) (Peptide transporter PSF2) ... (PSF-2) (Peptide transporter involved ... [Source:Uniprot/SWISSPROT;Acc:Q03519] ...
Goat polyclonal to JIK ( Abpromise for all tested applications). Antigen: Synthetic peptide: HKKDHVFIRDEAGHGD, corresponding to amino acids 396-411 of Human JIK. Entrez Gene ID: 51347 Swi...
Biology Products: