Navigation Links
Common viruses may cause cancer

In some cases, the fusion of human cells is a normal process that leads, for instance, to the formation of muscle and bone. Viral infections can also cause cell fusion, but cells fused by viruses are widely considered to be harmless because they are generally believed to die without consequences for the host. According to a recent study, however, cell fusion triggered by viruses is a possible contributing factor in the development of human cancer. The study also raises concerns about the use fusogenic viruses as vectors for human gene therapy or in other clinical applications owing to the possibility that such viruses might cause cancer.

The idea that aberrations in the number or structure of chromosomes can spur tumor formation is more than a century old. Such aberrations--known collectively as "aneuploidy"--arise in two principal ways: as a consequence of abnormal cell division, or as a result of cell fusion. By either mechanism, the resulting aneuploid cells no longer have the proper genetic makeup and frequently die. But researchers now know that tumor cells are often aneuploid--and very much alive. Whether aneuploidy is a cause or a consequence of a cancerous cellular state is the crux of a current debate.

In a recent study, Dr. Yuri Lazebnik and his colleagues at Cold Spring Harbor Laboratory observed, fortuitously, that normal cultured human cells are fused by the action of the Mason-Pfizer Monkey Virus (MPMV), but that the resulting hybrid cells do indeed fail to proliferate. However, the researchers discovered that if one of the fusion partners carried a particular "predisposing" gene mutation (in the oncogenes E1A or Myc, or in the tumor suppressor gene p53), then a significant proportion of the resulting hybrid cells were highly proliferative and thus potentially cancerous.

Whether such proliferating hybrid cells are produced by viruses in the human body, whether they can lead to cancer, and which of the many known and candidate hum an fusogenic viruses (for example, endogenous retroviruses, whose DNA sequences comprise at least 8% of the human genome) might contribute to cancer remain to be determined.

In addition to revealing that common viruses might contribute to cancer by fusing cells, the researchers report that the use of fusogenic viruses as vectors for gene therapy or in other clinical applications should be carefully evaluated.


'"/>

Source:Cold Spring Harbor Laboratory


Related biology news :

1. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
2. Harmful Bacterium Commonly Found in Poultry May Survive Refrigeration and Frozen Storage Combined
3. Men Estimate Mens Risks Of Common Disorders Higher Than Women Do, And Vice Versa
4. Use of Antibiotics for Acne May Increase Risk of Common Illness
5. Common alternative treatment for liver disease is found to be ineffective
6. Common molecular signature identified in solid tumors
7. Common bacteria pirate natural mechanism to get inside cells
8. Commonly used antidepressants may also affect human immune system
9. Common practices at petting zoos put visitors at risk
10. Common enzyme is a key player in DNA repair
11. Common molecular signature identified in solid tumors
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/3/2016)... May 3, 2016  Neurotechnology, a provider of ... MegaMatcher Automated Biometric Identification System (ABIS) , a ... projects. MegaMatcher ABIS can process multiple complex biometric ... combination of fingerprint, face or iris biometrics. It ... and MegaMatcher Accelerator , which have ...
(Date:4/19/2016)... -- The new GEZE SecuLogic access control ... system solution for all door components. It can be ... interface with integration authorization management system, and thus fulfills ... dimensions of the access control and the optimum integration ... considerable freedom of design with regard to the doors. ...
(Date:3/31/2016)... , March 31, 2016   ... ("LegacyXChange" or the "Company") LegacyXChange is excited ... of its soon to be launched online site for ... https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also provide potential shareholders a ... DNA technology to an industry that is notorious for ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... is pleased to announce the launch of their brand, UP4™ Probiotics, into Target ... over 35 years, is proud to add Target to its list of well-respected ...
(Date:6/23/2016)... 23, 2016 A person commits a crime, and ... to track the criminal down. An outbreak of ... Drug Administration (FDA) uses DNA evidence to track down the ... Sound far-fetched? It,s not. The FDA has increasingly used a ... of foodborne illnesses. Put as simply as possible, whole genome ...
(Date:6/23/2016)... , June 23, 2016  The Prostate Cancer Foundation (PCF) is ... treatments and faster cures for prostate cancer. Members of the Class of 2016 ... countries. Read More About the Class of 2016 PCF ... ... ...
(Date:6/23/2016)... ... ... Supplyframe, the Industry Network for electronics hardware design and ... in Pasadena, Calif., the Design Lab’s mission is to bring together inventors and ... brought to market. , The Design Lab is Supplyframe’s physical representation of one ...
Breaking Biology Technology: