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Common parasitic infection leads to increased risk for HIV infection

A new study shows a significantly increased risk of HIV infection among women with a common sexually transmitted disease, trichomoniasis. Although studies have been undertaken in the past to show the link between sexually transmitted infections and susceptibility to HIV, the study published in the March 1 issue of The Journal of Infectious Diseases, now available online, is one of the first to demonstrate a statistically significant association between trichomoniasis and HIV infection.

Trichomoniasis, caused by the parasite, Trichomonas vaginalis infects more than 170 million people worldwide each year. On its own, it usually does not cause serious complications. Some men may experience a mild burning sensation or discharge. Some women may have a frothy, strong-smelling yellow green discharge, and may feel discomfort during intercourse and urination, as well as itching of the genital area. Lower abdominal pain occurs in rare cases.

The study, conducted by R. Scott McClelland, MD, MPH, and colleagues at the University of Washington in Seattle, the University of Nairobi, and the Coast Provincial General Hospital in Kenya, followed 1,335 HIV-seronegative women over the span of 11 years. Because infection with T. vaginalis is common, even a modest increase in vulnerability to HIV acquisition as a result could mean a substantial attributable risk for HIV infection overall. According to McClelland, "the modest increase in risk makes it important that studies are either very large or of long duration in order to demonstrate such an effect."

Their results showed a 1.5-fold increased risk of HIV infection among women with trichomoniasis. "What this means is that a woman with trichomoniasis is at about fifty percent greater risk for acquiring HIV than a woman without trichomoniasis, after adjusting for other differences between the women such as differences in the rates of condom use, number of sex partners, etc." said McClelland.

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Source:Infectious Diseases Society of America


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