Navigation Links
Common molecular 'signature' identified in solid tumors

nia and George Calin found 137 different miRNAs expressed in at least half of the cancers, with 43 miRNAs allowing scientists to distinguish the difference between normal and malignant tissue.

Further tests showed that 21 of the distinguishing miRNAs were deregulated in at least three of the cancers ?and in some cases, as many as five or all six. The researchers defined this limited set as the "miRNA signature" in solid tumors.

Croce says finding such a signature is important because it shows that many forms of cancer share common genetic pathways that become scrambled as cancer takes hold and spreads. He says narrowing the list of the most active ones provides a guide to directing future research.

"We know that there are hundreds of miRNAs, and some of them may have multiple gene targets. Finding the ones that appear over and over again in various forms of cancer will help us design new and better interventions," says Croce.

MiRNAs can behave like oncogenes, which promote tumor growth, or tumor suppressors, which keep potentially malignant cells in check. Croce points out that miRNA activity is tissue-sensitive, meaning some miRNAs may be overexpressed, or "turned on" in some of the cancers while in others they are underexpressed, or "turned off."

In the six types of cancer in the study, the majority (26) of the miRNAs were overexpressed, while 17 were underexpressed.

Calin and Volinia also identified several key cancer genes the miRNA signature targets, including the tumor suppressors retinoblastoma-1 (RB1) and transforming growth factor, beta receptor 2 (TGFBR2).

Croce predicts that miRNAs themselves may one day be used as treatments. "If we can replace miRNAs that are lost and block those that are overly abundant, then maybe we can prevent some of the very earliest changes that happen in the development of cancer. There is a lot of work that still needs to be done, but I am convinced that this field
'"/>

Source:Ohio State University


Page: 1 2 3

Related biology news :

1. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
2. Harmful Bacterium Commonly Found in Poultry May Survive Refrigeration and Frozen Storage Combined
3. Men Estimate Mens Risks Of Common Disorders Higher Than Women Do, And Vice Versa
4. Use of Antibiotics for Acne May Increase Risk of Common Illness
5. Common viruses may cause cancer
6. Common alternative treatment for liver disease is found to be ineffective
7. Common molecular signature identified in solid tumors
8. Common bacteria pirate natural mechanism to get inside cells
9. Commonly used antidepressants may also affect human immune system
10. Common practices at petting zoos put visitors at risk
11. Common enzyme is a key player in DNA repair
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Common molecular signature identified solid tumors

(Date:12/10/2014)... , December 9, 2014 ... ITN,s BCARD Platform   ... enterprise meeting scheduling solutions for business-to-business (B2B) events, ... world leader in mobile near-field communication (NFC), Bluetooth ...      (Logo: http://photos.prnewswire.com/prnh/20140612/691055) , Jifflenow ...
(Date:12/5/2014)... , Dec. 4, 2014  Tute Genomics, a ... $2.3 million in Series A1 funding led by UK-based ... also participated in the investment round. "We ... healthcare community adopts next-generation sequencing and seeks new approaches ... Reid Robison , MD MBA, and CEO of ...
(Date:12/3/2014)...   Marvin Test Solutions , a trusted ... military, aerospace, and manufacturing organizations, today announced the ... TS-900 PXI semiconductor test platform . The TS-960 ... to customers at a fraction of the footprint ... "Our semiconductor customers asked for ...
Breaking Biology News(10 mins):Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3
... Bees among agriculture,s hardest workers as key pollinators ... declined over the last half-century, with die-offs in recent ... a $1.5 million National Science Foundation (NSF) multi-institutional grant ... consolidate data from 10 natural history bee collections across ...
... An Australian scientist has discovered what could be the world,s ... unique Pacific elkhorn coral was found while conducting underwater surveys ... Dr Zoe Richards of the ARC Centre of Excellence for ... physical resemblance to the critically endangered and fast-vanishing elkhorn coral ...
... Energy,s (DOE) Argonne National Laboratory will lead projects that ... time at Argonne,s Leadership Computing Facility (ALCF). The ALCF ... capable of performing 557 trillion calculations per second, enabling ... or months rather than years. "By providing millions ...
Cached Biology News:New $1.5 million NSF grant to track bee declines and pollination 2Super-rare 'elkhorn' coral found in Pacific 2Super-rare 'elkhorn' coral found in Pacific 3Supercomputers take science by storm 2Supercomputers take science by storm 3
(Date:12/13/2014)... 13, 2014 CanDiag, Inc., a University ... has changed its name to OncoTab, Inc. , ... where we are today,” said CEO and Chief Science ... applications beyond breast cancer diagnostics to include imaging and ... that evolution.” , Founded in 2011 by Dr. Mukherjee, ...
(Date:12/13/2014)... BELLLINGHAM, Washington, USA, and TAICHUNG, Taiwan (PRWEB) December 12, ... to rise, despite less rosy indicators in overall global ... international society for optics and photonics , said in ... the International Conference) on 5 December at the National ... cited solar energy, which is being integrated into future ...
(Date:12/13/2014)... Dec. 12, 2014  Vermillion, Inc. (NasdaqCM: VRML), a bio-analytical ... appointments of Veronica G. H. Jordan , Ph.D., ... Board of Directors, bringing the total number of directors ... Jim LaFrance , Chairman, President, and Chief ... to announce the appointments of Veronica and David to ...
(Date:12/12/2014)... InSphero AG, the world’s leading provider of 3D ... data presented recently by Genentech (South San Francisco, CA) ... model system for assessment of liver toxicity. ... Analysis and Screening Technologies (FAST) Congress summarized a ... 3D InSight™ Human Liver Microtissues to 42 known ...
Breaking Biology Technology:CanDiag Inc. Expands Product Scope Under a New Name: OncoTab, Inc. 2Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 2Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 3Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 4Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 5Vermillion Strengthens Board of Directors with Appointments of Veronica Jordan, Ph.D., and David Schreiber 2Vermillion Strengthens Board of Directors with Appointments of Veronica Jordan, Ph.D., and David Schreiber 3Enhanced Sensitivity of InSphero 3D Liver Microtissues Highlighted at Annual Screening Congress 2Enhanced Sensitivity of InSphero 3D Liver Microtissues Highlighted at Annual Screening Congress 3
... Switzerland, February 11 ,Acrongenomics, Inc. (OTCBB:AGNM), the Geneva ... and The Imperial Venture Fund a,time line for ... acquisition of 10.9% of the shares of Molecular ... agreed by all parties that the full,acquisition of ...
... Calif., Feb. 8 Anesiva,Inc. (Nasdaq: ANSV ) ... company,s board of directors. Mr. Janney previously served on ... transitioned off,the board following the merger of Anesiva and ... the Anesiva board of directors,and we are very pleased ...
... Medical today issued the,following response to a press release ... GmbH had achieved in the AIPPI in,AGA,s patent dispute ... sort was conducted before the AIPPI and that,organization agreed ... AGA has not been involved in any proceedings with ...
Cached Biology Technology:Acrongenomics on Track to Acquire Molecular Vision 2Acrongenomics on Track to Acquire Molecular Vision 3Acrongenomics on Track to Acquire Molecular Vision 4Anesiva Appoints Daniel Janney to Board of Directors 2Anesiva Appoints Daniel Janney to Board of Directors 3AGA Medical Corporation Responds to Occlutech Statement on the Status of the Ongoing Patent Litigation in Europe 2
... degrades single-stranded DNA and RNA endonucleolytically ... acids (DNA:DNA, DNA:RNA or RNA:RNA) are ... high concentrations of enzyme (1). The ... termini from double-stranded DNA (2), for ...
... catalyzes the transfer of the ... 5-terminus of polynucleotides or to ... The enzyme, purified from recombinant ... to phosphorylate RNA, DNA and ...
... verticillus USBio Analyzed PRODUCT SPECIFICATIONS Form: White powder Assay: 1.5 ... units/ml): 4.5 to 6.0 Loss On Drying: less than or ... 0.1% Bleomycin Content: A 2 : 55 - 70% B ... : greater than or equal to 90% B 4 : ...
A powerful, easy-to-use solution, the SORVALL RC12BP Blood Processing System allows you to manufacture blood components quickly and cost-effectively while ensuring product quality, safety, and GMP co...
Biology Products: