Navigation Links
Common molecular 'signature' identified in solid tumors

Scientists have discovered that a wide variety of different cancers actually share something in common ?a molecular "signature" made up of tiny bits of genetic material called microRNA (miRNA) that target key cancer genes and promote malignant growth.

The finding provides more insight into miRNA as an emerging class of gene regulators and may also pave the way for new approaches in diagnosis and treatment.

The study appears online in the Proceedings of the National Academy of Sciences.

Scientists have only recently begun to understand how important microRNA may be in regulating gene expression. For years, these tiny bits of genetic material went unnoticed ?nestled within vast stretches of the genome that appeared to be non-functional. They may have been easy to overlook: miRNAs are usually only 22 or so nucleotides in length ?miniscule in size when compared to their cousins, messenger RNA, which can be several hundred to a thousand times that long.

But several years ago, researchers studying roundworms noted that properly functioning miRNA was necessary for normal development. Since then, scientists in laboratories around the world have identified hundreds of miRNAs and found that they are highly conserved over time ?meaning that they show up in generation after generation in everything from plants to mice to humans ?confirming their important roles in growth and survival.

Carlo Croce, professor and chair of molecular virology, immunology and medical genetics at The Ohio State University and the first researcher to discover miRNA involvement in human cancer, had a hunch that there might be shared patterns of miRNA among certain cancers. Under his direction, researchers looked for miRNA activity, or expression, in 540 samples of lung, breast, stomach, prostate, colon and pancreatic tumors and in the normal tissue surrounding them.

Using microarray technology developed at Ohio State , lead investigators Stefano Voli
'"/>

Source:Ohio State University


Page: 1 2 3

Related biology news :

1. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
2. Harmful Bacterium Commonly Found in Poultry May Survive Refrigeration and Frozen Storage Combined
3. Men Estimate Mens Risks Of Common Disorders Higher Than Women Do, And Vice Versa
4. Use of Antibiotics for Acne May Increase Risk of Common Illness
5. Common viruses may cause cancer
6. Common alternative treatment for liver disease is found to be ineffective
7. Common bacteria pirate natural mechanism to get inside cells
8. Commonly used antidepressants may also affect human immune system
9. Common practices at petting zoos put visitors at risk
10. Common enzyme is a key player in DNA repair
11. Common molecular signature identified in solid tumors
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Common molecular signature identified solid tumors

(Date:3/12/2015)... 12, 2015 IriTech, a leading iris based ... the Texas Instruments Design Network, announced today that the ... its IriShield USB MK2120U device during a launching event ... distribution. The iris scanner is manufactured ... in India through its Indian ...
(Date:3/11/2015)...   The Sync Project™ today announced ... and harness music to improve health. The platform ... measurements of physiology, enabling the study of the ... populations. It is designed for medical and health ... studies and accelerate the discovery of the clinical ...
(Date:3/5/2015)... 5, 2015 In Brazil , ... already using these solutions and 42 percent planning to invest ... approximately 25 percent of the companies will be investing in ... majority of companies in the region are currently opting for ... model will command significant attention in the coming years. This ...
Breaking Biology News(10 mins):Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 3Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 2Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 3Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 2Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 3Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 4
... (April 1, 2013)Almost four million people die each year from ... of biomass fuels (wood, charcoal, crop residues, and dung), kerosene, ... who rely on such products to cook their meals, heat ... middle income countries are among the hardest hit by the ...
... "Geodynamics and Consequences of Lithospheric Removal in the Sierra ... USA, ignimbrite province and flareup: Swarms of subduction-related supervolcanoes ... dynamic lineup. Also in the April 2013 issue: themes ... (SMS) Drilling Projects" and "Exploring the Deep Sea and ...
... professor has found that about a thousand bird species ... Alison Boyer, a research assistant professor in ecology and ... rates of nonperching land birds in the Pacific Islands ... birds studied included birds of prey and ducks. The ...
Cached Biology News:Deadly effects of certain kinds of household air pollution lead to call for biomarker studies 2Deadly effects of certain kinds of household air pollution lead to call for biomarker studies 3Geosphere adds 2 new special issue themes 2Geosphere adds 2 new special issue themes 3Geosphere adds 2 new special issue themes 4Geosphere adds 2 new special issue themes 5Geosphere adds 2 new special issue themes 6Geosphere adds 2 new special issue themes 7University of Tennessee professor links massive prehistoric bird extinction to human colonization 2
(Date:3/26/2015)... The Market Element LLC, a leading inbound marketing ... Gig LLC to provide website design, development, and creative ... alliance with Designing Gig represents a pivotal moment for ... end-to-end, digital solution for our clients, which now includes ... president of The Market Element. “For small and mid-sized ...
(Date:3/26/2015)... 26, 2015 ReliantHeart, Inc., an innovative ... a supplier of precision transit-time flow measurement solutions, are ... improve the efficiency of the HeartAssist5® Left ... to experience greater mobility and peace of mind. ... flow board, will draw 1/6th of the power required ...
(Date:3/25/2015)... 2015 Agnition announced today that it ... Farmer, airing for the first time at 7:30 a.m. ... Farmer will explore the extremely important role soil microbes ... a patented Microbial Catalyst™ technology that enhances soil and ... segment will air again on April 28. , A ...
(Date:3/25/2015)... 25, 2015 Laboratory workers can ... and Analytical Balances to get best-performing features while ... weighing balances from the trusted brand include: , ... increase your efficiency by providing a large weighing ... Weighing modes include parts counting, percent weighing, checkweighing, ...
Breaking Biology Technology:The Market Element LLC and Designing Gig LLC Form Strategic Alliance 2LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 2LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 3Agnition to be Featured In Upcoming Episode of American Farmer on RFD-TV 2New Economical Top-Loading and Analytical Symmetry Balances from Cole-Parmer 2
... knowing how to conduct the proper interviews can make a ... right person. If its a top executive position for your ... candidates background is critical, but having a method in place ... the chances of hiring the right person. , ,Our ...
... GE Medical Systems today introduced AutoBone, ... by allowing clinicians to remove the bone structure ... that are hidden in traditional imaging views, which ... allow for less-invasive clinical procedures and increased diagnostic ...
... WAUKESHA, WI. - RedPrairie Corporation , has ... electronic product code (EPC)-compliant radio frequency identification ... in a real-world environment. The RFID Lab is ... tag placement and readability as they prepare for ...
Cached Biology Technology:Improving the Hiring Process 2RedPrairie Builds RFID Lab - Enables Real-World Testing 2
From the company that first brought you the chromatin immunoprecipitation (ChIP) kit, a new and improved kit, EZ-ChIP, is now available to make your experiments easier, quicker, and most importantly,...
... system uses a burst of high-pressure ... acid-coated gold or tungsten microparticles to ... or organelles without dependence or interaction ... includes helium pressure regulator, solenoid, spacer ...
... The Poly-Caspases FLICA Apoptosis Detection Kit ... is a carboxyfluorescein (FAM) derivative of valylalanylaspartic ... inhibitor of caspase activity. When added ... FLICA probe enters each cell and covalently ...
... Ciphergen's ProteinChip arrays have been developed ... biological samples. A variety of ProteinChip ... proteins according to their unique biochemical ... spots, allowing side-by-side sample comparison, and ...
Biology Products: