Navigation Links
Common bacteria pirate natural mechanism to get inside cells

et for finding better methods to prevent infections, Dr. Daaka says. "In the case of bacteria, hiding inside the cells is dependent on dynamin. What we could do is limit internalization and ensuing infection by controlling dynamin activity through the inhibition of nitric oxide synthases, enzymes that produce nitric oxide."

The new research uses the common bladder infection-producing uropathogenic E. coli as a model to show how nitric oxide unwittingly assists bacterial uptake and survival.

"In bladder cells, E. coli uses this mechanism to get inside the cells and hide from the antibiotic effect and the immune system," says Dr. Daaka. "We think their hiding is mediated through dynamin. This is not only applicable to this particular pathogen but for many more."

Dr. Daaka, who studies receptor signaling, likens receptors to television antennae that control relay of signals from outside the cell to inside by turning on or off. Although there are no known receptors that have the job of triggering a bad result in the body, receptors that are 'on' too much may end up instructing the cell to do bad things, he says. "The hypothesis is that in cancer, for example, the receptors get stuck on 'on'."

Receptor over-stimulation also helps explain why some drugs stop being effective over time. "What that means is there are no more receptors outside the cells to be affected by the drugs," Dr. Daaka says. "This is a self-regulatory mechanism for cells. You don't want your receptors to always be on."

Interestingly, this self-regulatory mechanism seems to work best when a receptor, not a bacteria, is the instigator. Unlike receptors, bacteria and viruses don't degrade if they stay inside the vesicles because fusion with a second vesicle that enables the degredation doesn't happen, says Dr. Daaka, a Georgia Cancer Coalition Distinguished Cancer Scholar.


'"/>

Source:Medical College of Georgia


Page: 1 2

Related biology news :

1. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
2. Harmful Bacterium Commonly Found in Poultry May Survive Refrigeration and Frozen Storage Combined
3. Men Estimate Mens Risks Of Common Disorders Higher Than Women Do, And Vice Versa
4. Use of Antibiotics for Acne May Increase Risk of Common Illness
5. Common viruses may cause cancer
6. Common alternative treatment for liver disease is found to be ineffective
7. Common molecular signature identified in solid tumors
8. Commonly used antidepressants may also affect human immune system
9. Common practices at petting zoos put visitors at risk
10. Common enzyme is a key player in DNA repair
11. Common molecular signature identified in solid tumors
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Common bacteria pirate natural mechanism get inside cells

(Date:7/10/2014)... NEW YORK , June 27, 2014 /PRNewswire/ ... against Provectus Biopharmaceuticals, Inc. ("Provectus" or the "Company")(NYSE-MKT: ... action, filed in United States District Court, Middle ... Division, is on behalf of a class consisting ... otherwise acquired Provectus securities between December 17, 2013 ...
(Date:7/10/2014)... -- NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication company focused on the ... was interviewed on July 1 st on the ... . Mr. Pereira discusses the company,s next generation smart wallet ... the Wocket™ aims to replace a traditional wallet with a ... tells Gino he has never heard of the Wocket ...
(Date:7/10/2014)... GOTHENBURG, Sweden , July 8, 2014 ... FPC1021 has won a new design win (DW). An Asian ... targeted date for mass production start in August 2014.   ... an Asian smartphone OEM, which has a planned date for ... received an initial ramp order of SEK 5M, for delivery ...
Breaking Biology News(10 mins):SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 2Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 4FPC Wins DW and Initial Ramp Order for FPC1021 Touch Sensor for Flagship Smartphone from Asian OEM 2
... biology textbooks, a single genetic mutation is rarely enough to ... a series of mutations that work together to trigger tumor ... that distinct cancer-causing mutations in neighboring cells can cooperate to ... Cancer biologists have long known that it takes ...
... , CARDIFF, Calif. , Jan. 13 ... Mind, Inc. was in high demand at this year,s Consumer Electronics Show ... many interviews with major media organizations during the 3 day event. Among ... Up TV , with Mark Albertson . Additionally, we have been ...
... Cold Spring Harbor, N.Y. Two scientists from ... international team that has discovered a genetic mutation that ... is a devastating inherited neurological disease that is very ... often among Ashkenazi Jews. The study was ...
Cached Biology News:Mutations in different cells cooperate to set the stage for cancer 2Mutations in different cells cooperate to set the stage for cancer 3Jedi Mind Receives Vast Media Coverage at CES in Las Vegas 2Jedi Mind Receives Vast Media Coverage at CES in Las Vegas 3CSHL scientists use next-gen sequencing to rapidly discover genetic cause of devastating disorder 2
(Date:7/10/2014)... quantum Hall effect in bilayer graphene and shown that ... an electric field. , The fractional quantum Hall ... sheets are exposed to large magnetic fields, is a ... electrons behave as a single system. However, while the ... details of this collective behavior remain not well understood, ...
(Date:7/10/2014)... recent study by researchers at the University of ... physical mechanisms governing the interplay of spin and ... limits of ultrafast spintronic devices for data storage ... charge as well as spin-angular momentum. In a ... there is no spin current," explained David Cahill, ...
(Date:1/15/2014)... , Jan. 15, 2014  Bill Jacobs Automotive, a group of ... teaming up with the Heartland Blood Center and offering free ... The drive takes place Saturday, Jan. 18 at the Bill ... p.m. (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  The ...
(Date:1/15/2014)... Cynvenio, a cancer diagnostics company focused ... analysis of tumor cells in the bloodstream, today announced ... decision support application powered by CollabRx, Inc. , ... test, Therapy Finder will provide breast cancer patients and ...
Breaking Biology Technology:Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3University of Illinois study advances limits for ultrafast nano-devices 2Join the Bill Jacobs Auto blood drive and receive a free oil change 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3
... can make a professor lose his cool more than having ... for making a mistake are endless: a DVD made specifically ... skipping around uncontrollably or even an overhead projector falling to ... duty of solving such technical issues and more falls on ...
... Madison, Wis. - If wireless keeps growing at its ... get their work done, says a wireless channel manager for ... at a recent Accelerate Madison program, saying the ... for corporations over the next few years. With costs falling ...
... Eau Claire, Wis . Faculty in the chemistry ... more than $600,000 in grant money from the National ... help them purchase state-of-the-art instrumentation and support faculty-student research. ... a department like ours and it'll have a significant ...
Cached Biology Technology:Interest drives investment of instructional technology 2Interest drives investment of instructional technology 3Interest drives investment of instructional technology 4Cisco manager touts wireless advantages 2UW-Eau Claire chemistry faculty get $600,000 in NSF grants 2UW-Eau Claire chemistry faculty get $600,000 in NSF grants 3
... E-PAGE Gels easier and more efficient by ... several types of pre-cut pre-assembled membrane/filter paper ... 13.5 cm E-PAGE Gels*. The available nitrocellulose ... western transfer of proteins (Figure 1 Table ...
... carbohydrate analysis standard is a lyophilized ... sugar alcohol; molecular weights range from ... provided for use with the Aminex ... kit for column testing or semiquantitative ...
... kit was tested on rat tissue extracts (liver, ... ( S. cerevisae ) extract. It was also ... and cell lines. Application: A simple and reliable ... based on the detection of the inorganic phosphate ...
... is the condition in which a lack ... and the various antioxidants. Oxidative stress ... of several diseases, including artherosclerosis, chronic inflammatory ... several antioxidant systems that are very important ...
Biology Products: