Navigation Links
Common bacteria pirate natural mechanism to get inside cells

et for finding better methods to prevent infections, Dr. Daaka says. "In the case of bacteria, hiding inside the cells is dependent on dynamin. What we could do is limit internalization and ensuing infection by controlling dynamin activity through the inhibition of nitric oxide synthases, enzymes that produce nitric oxide."

The new research uses the common bladder infection-producing uropathogenic E. coli as a model to show how nitric oxide unwittingly assists bacterial uptake and survival.

"In bladder cells, E. coli uses this mechanism to get inside the cells and hide from the antibiotic effect and the immune system," says Dr. Daaka. "We think their hiding is mediated through dynamin. This is not only applicable to this particular pathogen but for many more."

Dr. Daaka, who studies receptor signaling, likens receptors to television antennae that control relay of signals from outside the cell to inside by turning on or off. Although there are no known receptors that have the job of triggering a bad result in the body, receptors that are 'on' too much may end up instructing the cell to do bad things, he says. "The hypothesis is that in cancer, for example, the receptors get stuck on 'on'."

Receptor over-stimulation also helps explain why some drugs stop being effective over time. "What that means is there are no more receptors outside the cells to be affected by the drugs," Dr. Daaka says. "This is a self-regulatory mechanism for cells. You don't want your receptors to always be on."

Interestingly, this self-regulatory mechanism seems to work best when a receptor, not a bacteria, is the instigator. Unlike receptors, bacteria and viruses don't degrade if they stay inside the vesicles because fusion with a second vesicle that enables the degredation doesn't happen, says Dr. Daaka, a Georgia Cancer Coalition Distinguished Cancer Scholar.


'"/>

Source:Medical College of Georgia


Page: 1 2

Related biology news :

1. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
2. Harmful Bacterium Commonly Found in Poultry May Survive Refrigeration and Frozen Storage Combined
3. Men Estimate Mens Risks Of Common Disorders Higher Than Women Do, And Vice Versa
4. Use of Antibiotics for Acne May Increase Risk of Common Illness
5. Common viruses may cause cancer
6. Common alternative treatment for liver disease is found to be ineffective
7. Common molecular signature identified in solid tumors
8. Commonly used antidepressants may also affect human immune system
9. Common practices at petting zoos put visitors at risk
10. Common enzyme is a key player in DNA repair
11. Common molecular signature identified in solid tumors
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Common bacteria pirate natural mechanism get inside cells

(Date:5/17/2013)... Efficient and Sustainable Global Logistics Operations) is aiming to ... efficiency of intermodal loading systems and the boosting of ... European organisations with experience in the logistics sector and ... 17,000,000 and a duration of three and a half ... the semantic components and ontologies shared by the users, ...
(Date:5/17/2013)... Societies for Experimental Biology (FASEB) released a new ... trends highlighting the devastating impact of sequestration on the ... follows a May 15th Senate Appropriations Committee hearing featuring ... the $1.6 billion cut the agency sustained in FY ... on the scientific community." , According to data ...
(Date:5/16/2013)... Bethesda, MD (May 17, 2013) Illustrating a ... the American Gastroenterological Association (AGA) Research Foundation ... Future Student Research Fellowship Award recipients. Supported by ... Kidney Diseases (NIDDK), this new award helps underrepresented ... digestive disease and nutrition research. , "By establishing ...
Breaking Biology News(10 mins):New logistics services that will cut energy consumption and CO2 emissions 2Underrepresented minority students receive fellowships in digestive disease and nutrition research 2
... MAOne of the big, unsolved problems in explaining how ... could the basic biochemicalssuch as amino acids and nucleotideshave ... to carry out their formation? In a paper ... Bulletin, scientists propose that a third type of ...
... This release is available in Spanish . ... of fungi on peanuts, can be used on corn as ... (USDA) scientists who helped develop it. After extensive ... the U.S. Environmental Protection Agency (EPA) for use on corn, ...
... Researchers at Yale School of Medicine have developed a ... of eventually treating people with the disorder. Hemophilia A, a ... by a variety of mutations in the factor VIII gene. ... the study aimed to provide a better understanding of hemophilia ...
Cached Biology News:Transition metal catalysts could be key to origin of life, scientists report 2Transition metal catalysts could be key to origin of life, scientists report 3Yale develops new animal model for hemophilia A 2
(Date:5/17/2013)... Calif. , May 17, 2013  Cellular ... has achieved 50% enrollment of the total projected ... evaluate the safety and preliminary efficacy of the ... therapy for Knee Osteoarthritis (KOA). To date the ... reported. The Phase I open label ...
(Date:5/17/2013)... (PRWEB) May 17, 2013 Men’s skin is ... La-roche Posay ) and has been known to react ... some men may be far from puberty, other acne causing ... pores, causing breakouts, and threatening skin with unsightly acne scars. ... from Men’s Health on how to reduce and ...
(Date:5/17/2013)... 2013 IAC Industries wants to share with ... laboratory needing to set up and furnish a research lab ... facility within a year’s time. How does a company make ... is temporary? What is efficient and cost-effective? , The ... IAC Industries. The planners at DisperSol determined that the concept ...
(Date:5/16/2013)... 2013 Oven Industries, Inc. has been ... and temperature sensors since 1964. Expertly designed, the ... control system applications. As one of the ... generic, control loop feedback system, which helps minimize errors. ... adjust a systematic process, using a control element, like ...
Breaking Biology Technology:Cellular Biomedicine Group Achieves 50% Enrollment Milestone in Phase I Clinical Trial for Knee Osteoarthritis 2Adult Acne Treatment, Probiotic Action Shares New Insight on Why Men’s Skin Scars from Acne and How to Prevent It 2New Downloadable Success Story: “How To Outfit a Dynamic Lab in Flux” 2New PID Temperature Controllers Announced by Oven Industries Inc. 2
... , , , , , from rat lung, recombinant, , , ... , Catalog Number, Pack Size, ... 2000 units, , , 3335402, ... , , , , , , Package Inserts/Product , Instructions, ...
... carry-over prevention Cat. No. 1 585 541 , (1 Kit = 50 reactions) , ... , , The PCR Core Kit PLUS supplies all basic reagents to perform ... and appropriate primers. The kit contains: , , ... Taq DNA Polymerase , PCR Nucleotide MixPLUS , ...
... Polymerase for two-step RT-PCR amplification of up to 4 kb targets , ... , , , , , ... C. therm. Polymerase provided by Roche Applied Science is the recombinant , ... hydrogenoformans, expressed in E. coli. The recombinant enzyme lacks the , ...
Cached Biology Technology:PCR Core KitPLUS 2C. therm. Polymerase for Reverse Transcription in Two-Step RT-PCR 2
RABBIT ANTI NEOPTERIN...
MOUSE ANTI SIMIAN VIRUS 5:FITC Immunogen: Simian virus 5...
... Dog Serum-Mixed Breed • Dog serum is collected ... one year of age Available Anticoagulants: ... (Na) N-06: K2EDTA N-08: ... N-03: Alsevers N-05: ACD ...
Collected from normal, healthy animals in carefully maintained standing herds of US orgin. Pricing: $45/unit for 1 - 10 units...
Biology Products: