Navigation Links
Common ancestry of bacterium and plants could be key to an effective new treatment for chlamydia

ossible for the sequences to match so closely."

The ability to easily compare plants and bacteria is the result of genome sequencing, which has decoded the complete genetic blueprint for entire species. "This would not have been possible 10 years ago," said Leustek. "But now we have access to more that 500 different genomes in a data base. After having identified a gene in plants, I can quickly identify the homologous gene from any bacteria in the database. As a plant biologist I wouldn't have ever imagined that I would be working with Chlamydia. Yet, with the help of genomics I found myself working with a collaborator and publishing a paper in that area."

Their experiments revealed that in addition to sharing genome sequences, Chlamydia and plants share similar functions as well. Furthermore, they found that the pathway used by plants to produce lysine is probably used by Chlamydia to synthesize a chemical found in bacterial cell walls. It is the synthesis of cell walls that is inhibited by penicillin. This discovery points to the likelihood that, if researchers could find an inhibitor for L,L-diaminopimelate aminotransferase they would have a new antibiotic that would target Chlamydia.

Chlamydia trachomatis is a bacteria that is responsible for a common STD. If untreated, Chlamydia infections can damage a woman's reproductive organs and lead to infertility. An estimated 2.8 million men and women in the U.S. are infected with chlamydia each year. Chlamydia can be easily treated and cured with antibiotics. However, bacteria often develop resistance to antibiotics, meaning that new ones must be continually discovered. Moreover, an inhibitor to L,L-diaminopimelate aminotransferase would be very specific for Chlamydia since this enzyme has not been found in any bacteria that live with humans.

So the hunt for a new antibiotic is on. Leustek is going to start screening for chemicals that block the enzyme. He is also using the res
'"/>

Source:Rutgers, the State University of New Jersey


Page: 1 2 3

Related biology news :

1. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
2. Harmful Bacterium Commonly Found in Poultry May Survive Refrigeration and Frozen Storage Combined
3. Men Estimate Mens Risks Of Common Disorders Higher Than Women Do, And Vice Versa
4. Use of Antibiotics for Acne May Increase Risk of Common Illness
5. Common viruses may cause cancer
6. Common alternative treatment for liver disease is found to be ineffective
7. Common molecular signature identified in solid tumors
8. Common bacteria pirate natural mechanism to get inside cells
9. Commonly used antidepressants may also affect human immune system
10. Common practices at petting zoos put visitors at risk
11. Common enzyme is a key player in DNA repair
Post Your Comments:
(Date:12/19/2014)... and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has announced ... America Perimeter Security Systems Market" report to their ... The North American perimeter security market is estimated ... to 2019. Although the U.S. market holds a larger ... is expected to grow at a higher CAGR of ...
(Date:12/17/2014)... 15, 2014  HITLAB SM announced today ... audit to confirm its adherence to current U.S. ... enables HITLAB to conduct regulated smart device and ... for patient safety and research quality. ... quality, and delivery with innovative technology," said ...
(Date:12/11/2014)... --Research and Markets , ... ) has announced the addition of the ... to their offering. One major ... technology. With continuous advances in technology, it is ... standard that meets the needs and expectations of ...
Breaking Biology News(10 mins):Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... Philadelphia have manipulated cell activity that occurs during the ... in animal studies. The finding has the potential to ... since already existing drugs might be pressed into service ... or ischemia, is a major problem in many organs, ...
... reigned supreme on the Earth, thriving by filling every ... before humans first arrived on the scene. Now, ... infinite variety of food sources may play a significant ... crisis, according to the Biodesign Institute,s Bruce Rittmann, Rosa ...
... significant step closer to climbing into the driver,s seat of ... School of Medicine in St. Louis report in Nature ... HS1, enables key functions of natural killer (NK) cells, which ... allows the NK cells to pursue their targets, latch on ...
Cached Biology News:Novel approach may protect against heart attack injury 2Can microorganisms be a solution to the world's energy problems? 2Can microorganisms be a solution to the world's energy problems? 3Can microorganisms be a solution to the world's energy problems? 4Control switches found for immune cells that fight cancer, viral infection 2
(Date:12/22/2014)... , Dec. 22, 2014 /PRNewswire/ - RepliCel Life ... regenerative medicine company focused on the development of autologous ... out of the University of Calgary in conjunction with ... Carolina, which further validates the company,s ongoing clinical research ... effects of pattern baldness. The paper entitled ...
(Date:12/22/2014)... 2014  ( www.competitivehealth.com ) — Competitive Health is ... review and advocacy service, has signed an agreement to ... discount health services marketplace. 63% of Americans ... they expected to pay. As part of an ongoing ... Savings is pleased to offer medical bill review and ...
(Date:12/22/2014)... Memphis, TENN (PRWEB) December 22, 2014 ... with Donor Egg Bank USA , a network ... the country. Through this partnership, patients have fast access ... for in vitro fertilization, IVF . Fertility Associates of ... to offer this fertility treatment option. , Dr. ...
(Date:12/19/2014)... December 19, 2014 BioPlus Specialty ... pharmacies, announces the promotion of Nick Maroulis, Pharm.D. to ... Pharmacy Services. , In this position, Dr. Maroulis ... also managing the directors of our multi-site pharmacies as ... since 1997 and during that time he has served ...
Breaking Biology Technology:Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 2Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 4Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 5WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2
... Silence Therapeutics plc (London AIM:,SLN), a leading ... the successful opposition of a fundamental Alnylam,Pharmaceuticals, Inc. ... its entirety., The Opposition Division of the ... its decision to revoke European Patent EP 1,230 ...
... First-in-Man study success, Ovalum Ltd. launches a multicenter study using ... privately held Israeli medical device company, has announced today successful ... in the coronary arteries. , ... ...
... European Molecular Biology Laboratory (EMBL) discovered a new way to ... computational method that compares how similar the side effects of ... on the same target molecule. The study, published in ... drugs. , Similar drugs often share target proteins, modes of ...
Cached Biology Technology:Silence Therapeutics Announces Successful Opposition of Glover Patent 2Silence Therapeutics Announces Successful Opposition of Glover Patent 3Ovalum Ltd. Announces Success in Coronary Cases Using CiTop™ ExPander™ Guidewire 2Teaching old drugs new tricks 2
... the needs of the biopharmaceutical ... supports fast cell growth rates ... maintaining high cell viability and ... the Baculovirus Expression Vector System ...
A set of five proteins which can be used to calibrate a Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) or Electrospray Ionization (ESI) mass spectrometer....
... Ek Adaptor encodes a T7 promoter, ... ATG translation initation codon, and an N-terminal ... 109 aa sequence that encodes thioredoxin. Fusion ... enhance solubility of many proteins that are ...
... Disposable. Virgin, optically clear polystyrene with ... alphanumeric coordinates for cell counting. 100% ... is a new product number, created ... If showing no availability yet, please ...
Biology Products: