Navigation Links
Common algae helps illustrate mammalian brain electrical circuitry

in circuitry in a living, intact mammal, the researchers said.

The light-producing gene inserted into the mice is taken from the water-dwelling microorganism Chlamydomonas reinhardtii, which, as a plant, needs sunlight for photosynthesis. Tiny hairlike structures along the outside of the algae propel it toward the light. These structures are controlled by channelrhodopsin-2, a so-called "ion channel," which reacts to light by stimulating movement toward it.

While researchers previously have used channelrhodopsin-2 in a variety of experiments in cell culture, the Duke experiments mark the first time the gene controlling its action has been inserted into the genetic makeup of a living mammal, the researchers said. The mice were created by Ehlers' colleague Guoping Feng, Ph.D., assistant professor of neurobiology.

The researchers decided to test the mice first on the sense of smell, since the olfactory system not only involves complex neural circuits but also has a behavioral component.

"The perception of smell is quite complex," Ehlers said. "The brain can decode thousands of smells that enter the nose, discriminating even the slightest scent and often conjuring up vivid memories. So we wanted to know how the brain decodes the presence of these chemicals in the air and turn them into a perception. It's still quite mysterious."

Ehlers said that even though these experiments shed new light on the inner workings of the olfactory system, their greatest significance is that they provided proof of principle that this new model can be used to study a wide variety of questions involving the brain.

"There are a lot of tools that work well in simpler systems or in isolated nerve cells, but the findings are often difficult to translate into an intact mammalian brain," Ehlers said. "This new model opens up whole new avenues for study. We may reach a future where brain injuries, spinal cord damage, neuron loss in Alzheime
'"/>

Source:Duke University Medical Center


Page: 1 2 3

Related biology news :

1. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
2. Harmful Bacterium Commonly Found in Poultry May Survive Refrigeration and Frozen Storage Combined
3. Men Estimate Mens Risks Of Common Disorders Higher Than Women Do, And Vice Versa
4. Use of Antibiotics for Acne May Increase Risk of Common Illness
5. Common viruses may cause cancer
6. Common alternative treatment for liver disease is found to be ineffective
7. Common molecular signature identified in solid tumors
8. Common bacteria pirate natural mechanism to get inside cells
9. Commonly used antidepressants may also affect human immune system
10. Common practices at petting zoos put visitors at risk
11. Common enzyme is a key player in DNA repair
Post Your Comments:
(Date:12/19/2014)... , Dec. 18, 2014 Research and Markets ... the "iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... Apple introduced the fingerprint reading feature with the iPhone ...
(Date:12/19/2014)... 2014   LaunchKey , the first decentralized mobile authentication ... of Things era, today announced the close of $3 ... led by Metamorphic Ventures with participation from ENIAC Ventures, ... others.  LaunchKey has raised $4 million to date, and ...
(Date:12/17/2014)... YORK , Dec. 15, 2014  HITLAB SM ... (GCP) audit to confirm its adherence to current U.S. ... HITLAB to conduct regulated smart device and smart phone ... and research quality. "HITLAB is determined to ...
Breaking Biology News(10 mins):iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2
... available in German . , Helmholtz Zentrum ... European Union, has been expanded to include six partners from ... partners will join the effort of the other 22 members ... improve open access to high-quality mouse models. Animal models have ...
... Energy (DOE) Joint Genome Institute (JGI) now has a ... 13th Annual Applied Ergonomics Conference held March 22-25, 2010 ... highlights ergonomic innovations from institutions and multinational corporations. The ... for the Ergonomic Program Improvement Initiatives category. Ergonomics ...
... preliminary study by New Zealand company Plant & Food ... breathing in some types of asthma. Researchers found ... lung inflammation with a multi-action assault in allergy-induced asthma. ... the natural defence mechanisms in lung tissue by both ...
Cached Biology News:Biomedical research infrastructure goes global: EU consortium Infrafrontier has new partners 2Breathe easy: A natural fruit compound may help asthma 2
(Date:1/23/2015)... BioPharma Inc. (NASDAQ: ARRY ) today announced ... Pharma AG to acquire worldwide rights to encorafenib (LGX818), ... agreement is conditional on the closing of transactions announced by ... are expected to close in the first half of ...
(Date:1/22/2015)... 22, 2015 Shimadzu Scientific Instruments ... multipurpose UV-visible spectrophotometer. Offering wavelength scanning from 190 ... ideal for applications in a variety of industries, ... The user-friendly UV-1280 enables intuitive operation, while the ...
(Date:1/22/2015)... , Jan. 22, 2015  Transwestern | RBJ today announces the ... office space for Shire a leading biopharmaceutical company, at Two ... | RBJ,s Robert Richards , president, and Brian ... for the entire five-floor building at 95 Hayden Ave. ...
(Date:1/22/2015)... Protocol Networks brings independent technology consulting ... brand-neutral, independent consultants, Protocol Networks has recently announced its ... the years, his company has attracted several clients in ... as well as others. With the success of these ...
Breaking Biology Technology:Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 2Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 3Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 4Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 5Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 6Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 7Shimadzu’s New Monitored Single-Beam UV-Vis Spectrophotometer Offers Comprehensive Measurement Options in a Compact Body 2Transwestern?RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Protocol Networks Brings Independent Technology Consulting to the Constitution State 2
... , , , , , , ... To extract RNA from washed and pelleted cultured cells, add 200 , ... Isothiocyanate, 25 mM Sodium Citrate, pH 7.0, 1 M b-Mercaptoethanol) , ... 6 cells. , To directly extract RNA from cultured ...
... , , , Note: Genomic DNA is fragile. High molecular ... large-bore pipet tips or equipment when , pipetting genomic DNA. Do ... Place a 1 cm tail sample into a 1.5 ml ... at 20C. To minimize possible cross-contamination, , ...
... , , , , , , ... the , isolation of total RNA from cell and ... method, because the entire aqueous phase can be recovered , ... involved in RNA isolation with TRIzol Reagent and Phase Lock Gel-Heavy. ...
Cached Biology Technology:Total RNA Isolation Protocol 1,2,3 2Total RNA Isolation Protocol 1,2,3 3Mouse Tail Genomic DNA Isolation Protocol(1) 2Protocol for RNA Isolation Using TRIzol Reagent with Phase Lock , Gel-Heavy 2Protocol for RNA Isolation Using TRIzol Reagent with Phase Lock , Gel-Heavy 3
... organic acid analysis standard is ... organic salts; molecular weights range ... standard is provided for use ... and the organic acid analysis ...
Compound(s) tested through a broad panel of 38 ligand binding and enzyme assays targeting the Central Nervous System. Used to determine selectivity and potential CV/Renal liabilities of compounds....
Compound(s) tested through a broad panel of 38 ligand binding and enzyme assays targeting the Central Nervous System. Used to determine selectivity and potential GI liabilities of compounds....
... The ProteoSpin Detergent Clean-up Micro Kit provides ... removal of SDS, Triton X-100 and other detergents ... spin-column chromatography using Norgens patented protein resin as ... processing 2 50 g of either acidic or ...
Biology Products: