Navigation Links
Combined treatment extends life expectancy for lung cancer patients

Combining thermal ablation with radiation therapy extends average life expectancy and decreases recurrences of tumors in patients who have early stages of inoperable lung cancer, according to researchers at Rhode Island Hospital.

In a retrospective study looking at patients over seven years, the median survival rate at three years increased from 20 months after radiation alone to 42 months when thermal ablation was followed by radiation for treatment of non-small-cell lung cancer. The results are published in the July issue of the Journal of Vascular and Interventional Radiology.

"This study shows us that even patients who are not eligible for surgery can still get very good results," says senior author Damian Dupuy, MD, director of ultrasound at Rhode Island Hospital and professor of diagnostic imaging at Brown Medical School, both in Providence, RI. "By combining thermal ablation and radiation, you have a better chance of survival than with either treatment alone."

With radiation alone, overall survival rates were as follows:

one year ?57 percent
two years ?36 percent
three years ?21 percent

With thermal ablation and radiation, they were significantly higher:

one year ?87 percent
two years ?70 percent
three years ?57 percent

Surgery is the standard treatment for lung cancer. However, only one-third of patients with early stage lung cancer qualify for surgery because of other underlying medical conditions. Radiation therapy has long been used for inoperable lung cancer, and more recently, doctors have used radiofrequency ablation (RFA) and microwave ablation, processes that heat tumors to destroy them. For patients who cannot have surgery or radiation, the median survival is about one year.

In this study, researchers looked retrospectively at 41 patients treated over seven years with thermal ablation (RFA or microwave ablation) and either standard radiation therapy or b rachytherapy, a procedure in which a "seed" of radioactive material is implanted into the cancer or near it. Patients were diagnosed with Stage I or II lung cancer, meaning the lung cancer in most cases had not spread and was usually smaller than 3 centimeters, though not in all cases. While this study did not address the timing of combined treatment, brachytherapy radiation was typically administered within two hours of thermal ablation while external beam radiation was given within three to four weeks. Rhode Island Hospital may be the only hospital in the world to administer this combined treatment.

The recurrence rate was much lower with the combined treatment. With radiation therapy alone, about 50 percent of tumors recur within six to 12 months. By the end of this study, 24 percent of patients treated with ablation and radiation had recurrences at an average of 44 months. While there was an increased recurrence rate in larger tumors ?33 percent recurred at an average of 34 months ?the overall survival rate was the same for patients with large and small tumors.

"We found that just because the tumor returns, that doesn't mean the patient lives less long," Dupuy says.

The combined treatments work because they create a "synergy," the authors write. When tumors are targeted with radiation therapy, oxygen is vital to help the radiation damage DNA and kill cancerous cells. While radiation is most effective in destroying cells around the edges of the tumor, it is less effective at targeting the center of the tumor, which tends to be a low-oxygen environment.

Thermal ablation, on the other hand, heats the tumor to kill cancerous cells ?reaching the center of the tumor, but not necessarily killing all the cells at the edges. This can lead to a recurrence of the tumor, and the cancer may spread. Thermal ablation is delivered directly to cancerous cells with the guidance of a diagnostic image showing the tumor's location. However, if som e cancerous cells have spread into small channels of the lung around the tumor, they tend to be small and not visible on a radiology scan. Thermal ablation, which sends electrical current into the tumor, may not penetrate far enough into the lung to kill these areas of cancer.

When the two therapies are combined, they complement each other. Thermal ablation kills the central tumor. In exchange, radiation kills the cells on the periphery of the tumor and elsewhere in the lung that are missed by thermal ablation.

While this study looked only at lung cancer, Dupuy also has pioneered the use of RFA in thyroid, kidney, adrenal and bone cancer. The combined treatment may have far-reaching effects, Dupuy says.

"You might be able to treat tumors elsewhere in the body with similar results," Dupuy says. "There are a lot of opportunities for exploring the synergy of thermal ablation and radiation."


'"/>

Source:Lifespan


Related biology news :

1. Harmful Bacterium Commonly Found in Poultry May Survive Refrigeration and Frozen Storage Combined
2. Bevacizumab Combined With Chemotherapy Improves Progression-Free Survival for Patients With Advanced Breast Cancer
3. Protein discovery could unlock the secret to better TB treatment
4. Topical treatment shown to inhibit HIV and herpes simplex virus infection
5. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
6. Researchers add new tool to tumor-treatment arsenal
7. Potential treatments for neurofibromatosis
8. Nanoparticles offer new hope for detection and treatment
9. Technique may allow cancer patients to freeze eggs, preserving fertility before starting treatment
10. PET/CT can identify new cancer lesions at early stage, allowing for prompt treatment
11. New understanding of DNA repair may pave way to cancer treatments
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/22/2016)... , June 22, 2016   ... management and verification solutions, has partnered with ... software solutions for Visitor Management, Self-Service Kiosks ... provides products that add functional enhancements to ... provides corporations and venues with an automated ...
(Date:6/21/2016)... June 21, 2016 NuData Security announced today ... role of principal product architect and that ... of customer development. Both will report directly to ... The moves reflect NuData,s strategic growth in its ... high customer demand and customer focus values. ...
(Date:6/16/2016)... The global Biometric ... USD 1.83 billion by 2024, according to a ... proliferation and increasing demand in commercial buildings, consumer ... the market growth.      (Logo: ... of advanced multimodal techniques for biometric authentication and ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 27, 2016   Ginkgo Bioworks , a leading ... was today awarded as one of the World ... world,s most innovative companies. Ginkgo Bioworks is engineering ... real world in the nutrition, health and consumer ... with customers including Fortune 500 companies to design ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... of its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with ... in this eBook by providing practical tips, tools, and strategies for clinical researchers. ...
(Date:6/23/2016)... 23, 2016 Houston Methodist Willowbrook Hospital ... Sports Association to serve as their official health ... Methodist Willowbrook will provide sponsorship support, athletic training ... association coaches, volunteers, athletes and families. ... Sports Association and to bring Houston Methodist quality ...
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, the ... the Supplyframe Design Lab . Located in Pasadena, Calif., the Design Lab’s ... how hardware projects are designed, built and brought to market. , The Design ...
Breaking Biology Technology: