Navigation Links
Combination therapy with a monocloncal antibody and a vaccine leads to tumor rejection

Effector T cells (Teff cells) are involved in activating and directing other immune cells, while regulatory T cells (Tregs) act to curb the over-aggressive responses of the T cell population.

Researchers continue to work on devising ways to mobilize anti-tumor Teff cells in order to better shape the immune response to tumors. Previously, James Allison and colleagues from Memorial Sloan-Kettering Cancer Center, New York, demonstrated that an anti–CTLA4 monocloncal antibody used in combination with a vaccine expressing GM-CSF (Gvax) was able to eradicate skin and breast cancer in mice. In a new study appearing online on June 15 in advance of print publication in the July issue of the Journal of Clinical Investigation, this same research group investigated the effects of CTLA4 blockade on the balance between Teff cells and Tregs during tumor rejection.

The authors show that when cancer develops in mouse skin cells, Tregs accumulate in tumors, yet CD8+ Teff cells are underrepresented. They go on to demonstrate that blockade of CTLA4 lifts the inhibition of T cell proliferation and allows both Tregs and Teff cells to proliferate in response to exposure to self-antigen. Interestingly, combination of CLTA4 blockade with Gvax selectively primes the anti-tumor Teff cells for action. This led to greater infiltration of Teff cells into the tumor, and eventually to tumor rejection. Importantly, the authors report that chronic exposure to anti- CLTA4 or to the Gvax/anti-CTLA4 combination therapy does not deplete the number of Tregs, nor their regulatory activity, which suggests that upon completion of this therapy these cells would still be able to control possible adverse immune responses.


'"/>

Source:Journal of Clinical Investigation


Page: 1

Related biology news :

1. Combination therapy boosts effectiveness of telomere-directed cancer cell death
2. Combination therapy leads to partial recovery from spinal cord injury in rats
3. Combination therapy improves AIDS-related lymphoma outcome
4. Combination therapy shows promising results in patients with advanced lung cancer
5. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
6. Columbia research lifts major hurdle to gene therapy for cancer
7. Gene therapy converts dead bone graft to new, living tissue
8. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
9. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
10. Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
11. New therapy for HIV/AIDS eliminates needles and excessive toxicity
Post Your Comments:
(Date:9/22/2014)... (Sept. 22, 2014) As genetic sequencing technologies continue ... is a critical need to establish appropriate policies and ... experts have said. A special policy issue of the ... online today and edited by experts with the Center ... of Medicine gives policy makers the tools to jumpstart ...
(Date:9/22/2014)... Ill. Antarctic fishes that manufacture their own ... Ocean also suffer an unfortunate side effect, researchers ... their bodies resist melting even when temperatures warm. ... Proceedings of the National Academy of Sciences ... an undesirable consequence of the evolution of antifreeze ...
(Date:9/22/2014)... the fires captured in this image burn in Khabarovsk Krai, ... Dozens of red hotspots, accompanied by plumes of smoke mark ... blows to the east towards the Sea of Okhotsk. ... this area, swampy forest inhabit the central depression, and deciduous ... large wildfires are common in Russia in the summer, the ...
Breaking Biology News(10 mins):Experts provide much-needed policy analysis for clinical integration of next generation sequencing 2Experts provide much-needed policy analysis for clinical integration of next generation sequencing 3Study: Antifreeze proteins in Antarctic fishes prevent freezingand melting 2Study: Antifreeze proteins in Antarctic fishes prevent freezingand melting 3
... Medicine have developed a new animal model for studying hemophilia ... disorder. Hemophilia A, a hereditary defect that prevents blood from ... the factor VIII gene. Published online in the Journal ... better understanding of hemophilia A, according to first author and ...
... of the H5N1 ,bird flu, virus in South East Asia ... of wild birds could lead to global pandemic. Such fears ... Ecological Society,s Journal of Applied Ecology reveals why ... wildfowl is unlikely but also provides a new framework for ...
... Sept. 2, 2010 The American Society for Biochemistry ... week in response to the Aug. 23 ruling in ... that granted a preliminary injunction barring federal funding of ... said the decision, which came in response to a ...
Cached Biology News:Yale develops new animal model for hemophilia A 2Satellite data reveal why migrating birds have a small window to spread bird flu 2American Society for Biochemistry and Molecular Biology reacts to stem-cell ruling 2
(Date:9/23/2014)... September 23, 2014 Proove Biosciences ... will be presenting research on the association between specific ... U.S. Psychiatric and Mental Health Congress’ 27th ... conference focuses on the theme of ‘Embracing Change.’ Mental ... a changing landscape. From the challenges presented by the ...
(Date:9/23/2014)... Manassas, VA (PRWEB) September 23, 2014 ... organization, is pleased to announce two important appointments to ... as Executive Vice President of Strategy and Technology and ... Director for the Standards Resource Center. Both roles are ... Raymond H. Cypess, President and CEO at ATCC described ...
(Date:9/23/2014)... and ANNAPOLIS JUNCTION, MD (PRWEB) September 23, 2014 ... research leader in personalized medicine, presented industry leading research ... misuse this past weekend at the American Academy ... The meeting took place in Phoenix, Arizona at the ... study on the linkage between gender and genetic predisposition ...
(Date:9/23/2014)... Inc. (TSXV: BRM) ("Biorem" or "the Company") today announced three ... to $5 million. The orders are all odour control projects ... continue to see new orders coming in," said Peter ... has climbed to over $11 million." About ... company that designs, manufactures and distributes a comprehensive line of ...
Breaking Biology Technology:Proove Biosciences Will Be Exhibiting New Genetic Research at the 27th Annual US Psych Congress Scientific Program 2Proove Biosciences Will Be Exhibiting New Genetic Research at the 27th Annual US Psych Congress Scientific Program 3ATCC Announces New Appointments to its Leadership Team 2ATCC Announces New Appointments to its Leadership Team 3Proove Biosciences Will Be Exhibiting I.M.P.L.O.R.E Study at the American Academy of Pain Management 25th Annual Meeting 2Proove Biosciences Will Be Exhibiting I.M.P.L.O.R.E Study at the American Academy of Pain Management 25th Annual Meeting 3
... FluForecast(R) warning in April 7th, 2008, a year before ... was able to state the likelihood of H1N1 outbreaks ... examines specific regions in virus genes which have been ... as published on the Web, stated that in H1N1 ...
... Cellectricon, a leading,provider of automated screening solutions ... BioFocus DPI, a contract research organization with,leading ... will utilize,Cellectricon,s Dynaflow(R)HT, a fully automated patch ... screening capacity, particularly,for fast ligand-gated ion channels. ...
... Microparticles AB, the Swedish,life science technology company, ... production based on supercritical fluid technology.,The Company,s ... drawbacks of traditional micronization and is well ... all the advantages of earlier supercritical,fluid technologies ...
Cached Biology Technology:Biotechnology Company, Replikins Ltd., Provided Advance Warning of Mexican H1N1 'Swine Flu' Virus Outbreak 2Biotechnology Company, Replikins Ltd., Provided Advance Warning of Mexican H1N1 'Swine Flu' Virus Outbreak 3Cellectricon and BioFocus DPI Advance High Throughput ion Channel Drug Discovery 2Xspray Expands to Meet Pharma's Interest in its Ground-Breaking Particle Production Technology 2Xspray Expands to Meet Pharma's Interest in its Ground-Breaking Particle Production Technology 3
BioGenex IHC Kits for Rodent Tissues are designed for immunohistochemistry on rodent and rabbit tissues that are closely related to the source of the primary antibody. This kit comes with rat seconda...
... is available in a ready-to-use format. ... for dewaxing paraffin-embedded tissue sections prior ... or other analytical methods. The conventional ... dipping the slides in a series ...
... The BioGenex Super ... System is a novel ... proprietary non-biotin polymeric technology. ... high signal to noise ...
... thermal cycler is a compact instrument for gene ... tubes, 12 x 0.5 ml tubes, or a ... a thumbwheel to adjust height and pressure to ... heat pumps provide excellent thermal performance, and the ...
Biology Products: