Navigation Links
Combination therapy with a monocloncal antibody and a vaccine leads to tumor rejection

Effector T cells (Teff cells) are involved in activating and directing other immune cells, while regulatory T cells (Tregs) act to curb the over-aggressive responses of the T cell population.

Researchers continue to work on devising ways to mobilize anti-tumor Teff cells in order to better shape the immune response to tumors. Previously, James Allison and colleagues from Memorial Sloan-Kettering Cancer Center, New York, demonstrated that an anti–CTLA4 monocloncal antibody used in combination with a vaccine expressing GM-CSF (Gvax) was able to eradicate skin and breast cancer in mice. In a new study appearing online on June 15 in advance of print publication in the July issue of the Journal of Clinical Investigation, this same research group investigated the effects of CTLA4 blockade on the balance between Teff cells and Tregs during tumor rejection.

The authors show that when cancer develops in mouse skin cells, Tregs accumulate in tumors, yet CD8+ Teff cells are underrepresented. They go on to demonstrate that blockade of CTLA4 lifts the inhibition of T cell proliferation and allows both Tregs and Teff cells to proliferate in response to exposure to self-antigen. Interestingly, combination of CLTA4 blockade with Gvax selectively primes the anti-tumor Teff cells for action. This led to greater infiltration of Teff cells into the tumor, and eventually to tumor rejection. Importantly, the authors report that chronic exposure to anti- CLTA4 or to the Gvax/anti-CTLA4 combination therapy does not deplete the number of Tregs, nor their regulatory activity, which suggests that upon completion of this therapy these cells would still be able to control possible adverse immune responses.


'"/>

Source:Journal of Clinical Investigation


Page: 1

Related biology news :

1. Combination therapy boosts effectiveness of telomere-directed cancer cell death
2. Combination therapy leads to partial recovery from spinal cord injury in rats
3. Combination therapy improves AIDS-related lymphoma outcome
4. Combination therapy shows promising results in patients with advanced lung cancer
5. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
6. Columbia research lifts major hurdle to gene therapy for cancer
7. Gene therapy converts dead bone graft to new, living tissue
8. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
9. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
10. Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
11. New therapy for HIV/AIDS eliminates needles and excessive toxicity
Post Your Comments:
(Date:7/30/2014)... first high-resolution map of the carbon stocks stored ... The new and improved methodology used to make ... market-based carbon economies. The new carbon map ... it provides the critical input to studies of ... and enforcement purposes. The technique includes the determination ...
(Date:7/29/2014)... Washington, USA The advanced optical methods and applications ... driving a revolution in the neurosciences were the inspiration ... by SPIE, the international society for optics and photonics. ... the BRAIN Initiative in the United States, and a ... for and provide examples of the impact that optics ...
(Date:7/29/2014)... the wrong food at a restaurant, don,t blame yourself; blame ... do with what you want and more to do with ... and the selections of over 300 diners, the Cornell study ... Management showed that when it comes to what you ... on the menu and how you imagine it will taste. ...
Breaking Biology News(10 mins):Peru's carbon quantified: Economic and conservation boon 2Peru's carbon quantified: Economic and conservation boon 3SPIE launches Neurophotonics journal with special section on BRAIN Initiative 2SPIE launches Neurophotonics journal with special section on BRAIN Initiative 3Menu secrets that can make you slim by design 2
... Scientists at Michigan State University have identified a ... could ultimately lead to plant varieties tailored specifically ... compartments in plant cells, convert sunlight, carbon dioxide ... the plant) during photosynthesis. The newly discovered protein, ...
... researchers are urging companies to embrace new methods for following ... much of the world,s global warming threats. , ... Because there is no universally accepted ... have sprung up on the Internet in the past few ...
... Institute of Technology have developed a novel way ... antiplaque toothpaste additives, antibiotics, nicotine, and even morphine, ... the research, now available online, will be featured ... of Nature Chemical Biology . Christina ...
Cached Biology News:MSU's discovery of plant protein holds promise for biofuel production 2Carnegie Mellon urges industry to broaden carbon footprint calculations 2Caltech engineers build mini drug-producing biofactories in yeast 2
(Date:7/30/2014)... 30, 2014 Vycom announces the addition ... designed to meet Factory Mutual (FM) 4910 fire propagation ... as wet benches, process tools, fume hoods, furniture and ... damage to semiconductor wafers used in electronic chip manufacturing. ... PVC solution with excellent workability and superior aesthetics. It ...
(Date:7/30/2014)... July 30, 2014 Researchers often use ... biology, but such devices can do much more ... As such, researchers have looked to patterned assemblies ... metabolic engineering to characterize – and potentially ... devices are envisioned to recreate animal and human ...
(Date:7/30/2014)... 30, 2014 NCERC at Southern ... present his findings on corn stover pretreatment methods ... week in Washington, D.C. , “Arun’s selection ... is a testament to the success of our ... “Thanks to the foresight and vision of SIUE ...
(Date:7/30/2014)... 2014 Immunology Summit-2014 ... Principle Investigators, scientists in the field, which includes ... at Case Western Reserve University School of Medicine, ... on “The effects of recombinant human IL-6 ... metalloproteinase-9”. Arya Biragyn, a Senior investigator at National ...
Breaking Biology Technology:Vycom Announces Flametec® Thermax PVC (FM4910 Listed) For a Variety of Clean Room Applications with Excellent Workability and Aesthetics 2UMD Researchers Bridge Gap between Microelectronics, Biological Systems 2UMD Researchers Bridge Gap between Microelectronics, Biological Systems 3UMD Researchers Bridge Gap between Microelectronics, Biological Systems 4NCERC at SIUE Researcher Takes Stage at Department of Energy Conference 2NCERC at SIUE Researcher Takes Stage at Department of Energy Conference 3Unveiling Breakthroughs in Clinical & Cellular Immunology 2Unveiling Breakthroughs in Clinical & Cellular Immunology 3
... PLEASANTON, Calif., April 20 Thoratec Corporation (Nasdaq: ... circulatory support therapies to save, support and restore failing ... (Pre-Market Approval) supplement with the FDA seeking to add ... the HeartMate II LVAS (left ventricular assist system). The ...
... Pharmaceuticals, Inc. (Nasdaq: ISIS ) announced today ... inhibition of novel targets that could offer new mechanisms ... Research (AACR) meeting. Research conducted by Isis and ... non-coding RNA, sigma RNA also known as Malat-1, that ...
... Advanced Instruments, Inc . ... the first true automation-friendly osmometer for the biopharmaceutical ... is specifically designed for -- and completely ... the biopharmaceutical laboratory," said Kelly Peterson, Product Manager, ...
Cached Biology Technology:Thoratec Announces Filing of PMA Seeking Destination Therapy Approval for HeartMate II(R) 2Thoratec Announces Filing of PMA Seeking Destination Therapy Approval for HeartMate II(R) 3Thoratec Announces Filing of PMA Seeking Destination Therapy Approval for HeartMate II(R) 4Isis and Partners Present New Research at the American Association for Cancer Research 2009 Annual Meeting 2Isis and Partners Present New Research at the American Association for Cancer Research 2009 Annual Meeting 3Advanced Instruments Introduces 2020-BIO Multi-Sample Osmometer as First True Automation-Friendly Osmometer for the Biopharmaceutical Industry 2Advanced Instruments Introduces 2020-BIO Multi-Sample Osmometer as First True Automation-Friendly Osmometer for the Biopharmaceutical Industry 3
...
Lyophilized. Purity: ≥90% by electrophoresis. Reconstitute in 0.3% NaCl. Prepared from serum that has been shown by certified tests to be negative for HBsAg and for HIV and HCV antibodies. ...
Porcine Pulmonary Artery Endothelial Cells (PPAEC) (>500,000 cells)...
PP2B-Abeta (C-20)...
Biology Products: