Navigation Links
Combination therapy shows promising results in patients with advanced lung cancer

An early phase study pairing an experimental targeted therapy with a common anti-inflammatory produced promising results in patients with advanced lung cancer, researchers at UCLA's Jonsson Cancer Center reported.

Pairing the targeted therapy Tarceva with the anti-inflammatory drug Celebrex increased response rates in lung cancer patients by about three-fold, said Dr. Karen Reckamp, an assistant professor of hematology/oncology and lead author of the study. The research appears in the June 1 issue of Clinical Cancer Research, the peer-reviewed journal of the American Association of Cancer Research.

Previous laboratory studies at UCLA showed that a cell signaling pathway known as COX-2 may be linked to resistance to drugs like Tarceva, which block tumor cell growth by targeting the protein EGFR, or epidermal growth factor receptor. Researchers theorized that giving Tarceva with Celebrex, a COX-2 inhibitor, would help battle resistance and prove to be an affective combination against lung cancer.

Typically, about 10 percent of lung cancer patients respond to Tarceva. In Reckamp's study of the combination therapy, about 33 percent of patients responded.

"Tarceva alone is a great drug and has a lot of clinical benefits, but for a small proportion of patients," Reckamp said. "With this drug combination, we saw an increase in response rates, indicating we are overcoming some resistance. We also may be beginning to understand the mechanisms of that resistance."

Volunteers in the Phase I study, patients with advanced lung cancer that had failed to respond to all conventional therapies, took several Celebrex pills and one Tarceva pill each day. After eight weeks, researchers looked at response rates. Patients were able to stay on the study as long as they didn't experience tumor growth. The longest duration of response was 93 weeks, Reckamp said, about three to four times longer than the average duration of response for a patient with
'"/>

Source:University of California - Los Angeles


Page: 1 2 3

Related biology news :

1. Combination therapy boosts effectiveness of telomere-directed cancer cell death
2. Combination therapy leads to partial recovery from spinal cord injury in rats
3. Combination therapy improves AIDS-related lymphoma outcome
4. Combination therapy with a monocloncal antibody and a vaccine leads to tumor rejection
5. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
6. Columbia research lifts major hurdle to gene therapy for cancer
7. Gene therapy converts dead bone graft to new, living tissue
8. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
9. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
10. Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
11. New therapy for HIV/AIDS eliminates needles and excessive toxicity
Post Your Comments:
(Date:5/11/2015)... JOSE, Calif. , May 11, 2015 /PRNewswire/ ... developer of human interface solutions, today announced the ... Vice President and Chief Financial Officer, reporting to ... Ali replaces Synaptics, current Chief Financial Officer, ... December 2014. Mr. Ali brings ...
(Date:5/7/2015)... , May 7, 2015 ... sensors, FPC1022 and FPC1035, FPC,s smallest touch fingerprint ... are mainly considered for integration on the backside ... smartphone OEMs increased possibilities to integrate touch fingerprint ... size also improves possibilities for module manufacturers to ...
(Date:4/27/2015)... 2015 Profile Solutions, Inc. (OTC: PSIQ), a ... is pleased to announce that Dr Gerry Bedore ... member of its scientific advisory board. ... thought leader in technology-enhanced learning models. He was a ... published studies and books focused on online student success ...
Breaking Biology News(10 mins):Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4
... need to be made to the way ski pistes ... protected, ecologists have warned. According to new research published ... Ecology, machine grading and artificial snow production is causing ... species in the European Alps. , Sonja Wipf of ...
... might do a better job of keeping the doctor ... eight popular varieties of the fruit. Red Delicious, Northern ... wallop of disease-fighting antioxidants than other apples studied. , ... and Agri-Food Canada in Guelph, Ontario, also pinpointed the ...
... providing scientists with a better understanding of why some ... to treatment even when existing clinical predictive criteria point ... the April issue of Cancer Cell, is likely to ... and treatment failure for children with ALL. , Nearly ...
Cached Biology News:Taking the piste out of Alpine vegetation 2Red delicious, Northern Spy apples have most antioxidants, chemists find 2Multiple-drug resistant gene expression pattern predicts treatment outcome for pediatric leukemia 2
(Date:6/3/2015)... ROOSEVELT, N.J. , June 3, 2015 /PRNewswire/ ... Life Science industries, will host its 6 th ... and Exposition Center at Raritan Center in ... 2015.  Event sponsors include Novo Nordisk, Covance, Actavis ... companies that will be exhibiting are Johnson & ...
(Date:6/3/2015)... Innovative biomass supply chain industry leader, Genera Energy ... first annual Advanced Bioeconomy Feedstocks Conference (ABFC) ... Orleans, June 9-10, the conference brings together leaders in ... advancements of feedstock by discussing pressing issues such as ... and more. , As a tier-one sponsor, ...
(Date:6/3/2015)... and CAMBRIDGE, Mass. and REYKJAVIK, Iceland , ... precision medicine company using the genome to improve health ... Genomics England (GeL) to provide clinical interpretation ... and cancer patients as part of the first phase ... National Health Service (NHS). WuXi NextCODE ...
(Date:6/3/2015)... (PRWEB) June 03, 2015 Marktech Optoelectronics ... Avalanche Photodiodes. Marktech APD’s have an internal gain mechanism, ... in the near infrared region. These APD’s are recommended ... gain is needed to overcome high pre-amp noise. In ... photodiode and are ideal for extreme low-level light detection ...
Breaking Biology Technology:AstraZeneca Added as Sponsor for Industry Leading Life Science Hiring Event 2Genera to Sponsor Advanced Bioeconomy Feedstocks Conference 2015 2Genera to Sponsor Advanced Bioeconomy Feedstocks Conference 2015 3WuXi NextCODE Wins Genomics England Clinical Interpretation Tender in both Rare Disease and Cancer 2Marktech Introduces New Line of APDs 2
... Senior-friendly ,PlanPrescriber, Software Simplifies Medicare - For Free, ... today,announced the latest release of their PlanPrescriber tool. ... worry about whether they are,getting the most out ... MIT Professor Glen Urban, provides users with easy ...
... Scientific Operations, NAPLES, Fla., Sept. 8 ... advanced third generation biofuels,technology, today announced the appointment ... Dr. Coleman, currently the Vice-Principal Research and,Graduate Studies ... years of,experience in the fields of molecular biology ...
... Sept. 8 Environmental,Tectonics Corporation,s (Amex: ETC ... announced today the award of two new contracts. ... (M-138) and a,new cGMP Pharmaceutical Sterilization System to ... steam sterilizer (NSN 6530 00 926 2151), also,known ...
Cached Biology Technology:On-Line Medicare Advisor Saves Seniors Time, Hassle and Money 2Algenol Biofuels Appoints Chief Science Officer 2Environmental Tectonics Corporation's Sterilization Systems Group Announces New Contracts 2Environmental Tectonics Corporation's Sterilization Systems Group Announces New Contracts 3
Mouse monoclonal [YPF19] to Yersinia pestis F1 antigen ( Abpromise for all tested applications)....
This CLS number is a new product number, created to easily match Cornings product number. If showing no availability yet, please order under the old Sigma-Aldrich number (E6027) or contact customer s...
A convenience pack containing one each of the most popular sizes of Cat. No. 4980 flask. Designed for the low volume user, a case contains one each of five sizes: 50mL, 125mL, 250mL, 500mL, and 1L....
... range has now been expanded ... quaternary low pressure mixing pump ... mixing pump. These space ... even more versatility to modular ...
Biology Products: