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Combination therapy improves AIDS-related lymphoma outcome

in Bremen, Germany, treated 72 HIV-patients with ARL divided into high-risk and standard-risk cohorts with combined CHOP and HAART to evaluate the safety and efficacy of the combined regimen.

The investigators found combined therapy improved survival rates for patients with ARL and standard level of risk to rates comparable to those in non-HIV patients with lymphoma treated with CHOP and superior to previously published rates achieved by CHOP alone. For standard-risk ARL patients 79 percent achieved complete remission, and after 47 months of follow-up and study's end, more than 50 percent of patients survived. Moreover, only 40 percent reported moderate drug toxicity. For high-risk ARL patients, only 29 percent achieved complete remission and median survival was only 7.2 months. Sixty-nine percent reported moderate toxicity.

"The present study showed that our risk-adapted strategy for concomitant administration of HAART with CHOP is effective and safe," the authors concluded.


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Source:John Wiley & Sons, Inc.


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