Navigation Links
Columbia scientists develop cancer terminator viruses

irus did, this virus carried a gene called mda-7/IL-24, a novel gene identified and cloned in Dr. Fisher's laboratory, which is selectively toxic to cancer cells and is now in phase II clinical trials as a cancer gene therapeutic.

"We are extremely excited about these results and the prospect of one day using a form of the cancer terminator virus in human clinical trials," said Dr. Fisher, the study's senior author. "While the results of these trials need to be investigated further and replicated in future trials, we believe that viral-based therapies will someday soon be a standard part of the cancer armamentarium."

About the "Terminator" Viruses

The "terminator" viruses have the potential to become effective treatments for a wide range of tumors - such as ovarian, pancreatic, breast, brain (glioma), prostate, skin (melanoma) and colon cancer - because the virus is constructed to exploit a characteristic of all solid cancers. However, clinical trials are necessary before such treatments can be approved by the U.S. Food and Drug Administration and available for patients.

These publications are a continuation of research published in the Jan. 25, 2005 issue of PNAS, where the same research team, also led by Dr. Fisher, incorporated gene therapy into a specially designed non-replicating virus to overcome one of the major hurdles of gene therapy: its tendency to kill normal cells in the process of eradicating cancer cells. The virus eradicated prostate cancer cells in the lab and in animals, while leaving normal cells unscathed.

The present cancer "terminator" viruses represent the next generation of therapeutic viruses that permit replication uniquely in cancer cells with simultaneous production of immune modulating and toxic genes. These viruses effectively eliminate primary tumors and distant tumors (metastases) without harming normal cells or tissues.

Dr. Fisher's cancer research team includes Columbia Un
'"/>

Source:Columbia University Medical Center


Page: 1 2 3

Related biology news :

1. Columbia research lifts major hurdle to gene therapy for cancer
2. Columbia study shows widely used artery clearing device does not help patients during heart attack
3. Contaminants linked to sturgeon decline in Columbia river
4. Columbia University licenses next-generation DNA sequencing technology
5. New bird discovered on unexplored Columbian mountain
6. Columbia scientists determine 3-dimensional structure of cells fuel gauge
7. Wisconsin scientists grow critical nerve cells
8. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
9. UAB scientists discover the origin of a mysterious physical force
10. Fox Chase Cancer Center scientists identify immune-system mutation
11. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Columbia scientists develop cancer terminator viruses

(Date:4/27/2015)... 27, 2015  For more than four decades, AUVSI,s ... been the premier worldwide event for the unmanned land, ... must-attend event for any local, national, or trade news ... commercial markets and current applications of unmanned technologies. The ... projected $48 billion industry, and how it will soon ...
(Date:4/20/2015)... The announcement comes as demand ... Management (GRM), Ireland,s foremost records management ... built up an impressive track record of clients within the ... the records management sector in Dubai . ... staffbase and employ a further eight staff members at its ...
(Date:4/13/2015)...  higi, a leading cloud-based consumer engagement platform that ... with their communities around health and wellness, announced today ... API.  ... and convenient vehicle to receive validated health information from ... The API will allow higi,s trusted partners, on a ...
Breaking Biology News(10 mins):UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3
... the Grand Canyon may be so old that dinosaurs once ... from the University of Colorado at Boulder and the California ... as radiometric dating to show the Grand Canyon may have ... assumed origins by 40 million to 50 million years. ...
... . Researchers from all over the world have ... from mouth and saliva cells to carry out the DNA ... (director of the Laboratory of Genetic Identification of the ... commissioned by the court in cases of paternity tests, for ...
... with a Canberra-based company Dyesol, which is developing transparent solar ... houses or commercial buildings. He said the solar cell ... owners energy costs and could in fact generate excess energy ... the glass was one of a number of practical technologies ...
Cached Biology News:Grand Canyon may be as old as dinosaurs, says new study 2Grand Canyon may be as old as dinosaurs, says new study 3Fraud attempt in a paternity test modifies action protocol in DNA tests 2
(Date:5/6/2015)...   University of Maryland (UM) Ventures and ... of an exclusive option by Biomecite Diagnostics for the ... diagnostics to detect inflammatory bowel diseases (IBD), such as ... Florian Fricke and James White developed ... of Maryland School of Medicine,s Institute for Genome Sciences ...
(Date:5/6/2015)... May 6, 2015 ... specialist, announced today that it has signed an agreement ... PEIX ) for the delivery of an industrial scale ... the consumption of water, energy and emissions ... This project is fully aligned ...
(Date:5/5/2015)... RURO, Inc., a leading LIMS, RFID and sample ... major content upgrade to its bestselling, Commercial Off-The-Shelf (COTS) ... a significant advancement of FreezerPro® system , ... also simplifying , New FreezerPro® VM ... Download available immediately for free to “Gold” support subscribers ...
(Date:5/5/2015)... 2015  23andMe, Inc., the leading personal genetics company, ... Study in collaboration with Pfizer Inc. The companies ... more commonly known as lupus, into the study to ... is also in collaboration with the Lupus Research Institute, ... Approximately 1.5 million people in the U.S. ...
Breaking Biology Technology:Biomecite Diagnostics Signs Option Agreement with UM Baltimore to Develop Tools to Detect Inflammatory Bowel Diseases 2Biomecite Diagnostics Signs Option Agreement with UM Baltimore to Develop Tools to Detect Inflammatory Bowel Diseases 3Whitefox Signs Agreement With Pacific Ethanol Inc. 2RURO Releases version 7 of FreezerPro® software 223andMe Launches the Lupus Research Study in Collaboration with Pfizer Inc. 223andMe Launches the Lupus Research Study in Collaboration with Pfizer Inc. 3
... 6, 2011 Genprex, Inc., formerly known as ... the nanomolecular cancer therapy CNVN202, will be branded as ... Oncoprex brand in the oncology sector in recognition of ... Oncoprex will be used to unlock the unrealized potential ...
... AMSTERDAM, September 6, 2011 , Gains ... Amsterdam Molecular Therapeutics (Euronext: AMT), a leader in ... it has entered into an exclusive license agreement with ... of adeno-associated virus serotype 5 (AAV5)-based gene therapy vectors ...
... terahertz light is invisible it,s at the farthest end ... from detecting explosives at the airport to designing drugs to ... the U.S. Department of Energy,s Lawrence Berkeley National Laboratory (Berkeley ... a microscale device made of graphene the remarkable form ...
Cached Biology Technology:Genprex Announces New Branding 2Amsterdam Molecular Therapeutics Licenses Additional Novel Gene Therapy Vectors from National Institutes of Health 2Amsterdam Molecular Therapeutics Licenses Additional Novel Gene Therapy Vectors from National Institutes of Health 3A whole new light on graphene metamaterials 2A whole new light on graphene metamaterials 3
Active GST Protein...
Cyno macaque plasma and serum - various quantities available...
adult...
Natural Mouse Laminin is purified from the Engelbreth-Holm-Swarm (EHS) sarcoma and is provided in Tris-buffered saline....
Biology Products: