Navigation Links
Columbia scientists determine 3-dimensional structure of cell's 'fuel gauge'

Researchers at Columbia University Medical Center have uncovered the complex structure of a protein that serves as a central energy gauge for cells, providing crucial details about the molecule necessary for developing useful new therapies for diabetes and possibly obesity. A paper published online today in the journal Science details this structure, helping to explain one of the cell's most basic and critical processes.

"Understanding this important protein's molecular structure and mechanism provides a major step forward for the rational design of new drugs to target diabetes and obesity," said Lawrence Shapiro, Ph.D., associate professor of Biochemistry and Jules and Doris Stein Professor of Research to Prevent Blindness at Columbia University Medical Center, and senior author of the paper.

The protein, known as AMP-activated protein kinase or AMPK, controls metabolic decisions of cells. For example, it controls the decision regarding whether fat is stored or burned, based on the amount of energy in the cell. When the energy level of a cell is high, meaning that the cell contains high amounts of an energy-carrying molecule known as ATP, AMPK directs cells toward "anabolic" activities like storing the extra energy as fat. When ATP is low, AMPK turns off anabolic activities, and activates "catabolic" functions, like burning fat to make energy.

AMPK provides an especially promising drug target for people with type 2 diabetes. These patients are insulin-resistant, meaning that their cells are not responsive to insulin which normally helps glucose get out of the bloodstream, where it does damage, and into cells. When AMPK detects low levels of ATP in the cell, it works through a different mechanism to increase how much glucose the cell takes in and uses to create ATP. Research in rodent models has shown that AMPK activators can lessen the pathologies associated with diabetes, including problems that diabetics have regulating blood su
'"/>

Source:Columbia University Medical Center


Page: 1 2

Related biology news :

1. Columbia research lifts major hurdle to gene therapy for cancer
2. Columbia study shows widely used artery clearing device does not help patients during heart attack
3. Columbia scientists develop cancer terminator viruses
4. Contaminants linked to sturgeon decline in Columbia river
5. Columbia University licenses next-generation DNA sequencing technology
6. New bird discovered on unexplored Columbian mountain
7. Wisconsin scientists grow critical nerve cells
8. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
9. UAB scientists discover the origin of a mysterious physical force
10. Fox Chase Cancer Center scientists identify immune-system mutation
11. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
Post Your Comments:
(Date:9/15/2014)... and gut microbes influence processes from digestion to disease ... most biodiverse terrestrial ecosystems on the planet, more is ... the tropics. Smithsonian scientists and colleagues working on Panama,s ... a single tree were home to more than 400 ... tree species contained more than 7,000 different kinds. , ...
(Date:9/15/2014)... 2014) The so-called central dogma of molecular ... provided a simplified explanation for how genetic information ... , In reality, of course, the process is ... nearly 60 years ago by Nobel Laureate Francis ... one, there are multiple types of RNA, three ...
(Date:9/15/2014)... populations may continue to drop in French Guiana, despite ... National de la Chasse et de la Faune Sauvage ... data retrieved from camera traps in the Nouragues National ... data to current harvest rates in the region., "In ... Guiana," said Matthias Tobler, a scientist with the San ...
Breaking Biology News(10 mins):Smithsonian scientists discover tropical tree microbiome in Panama 2Scientists discover RNA modifications in some unexpected places 2
... growing asthma rates among children with exposure to ... study in the May issue of Journal ... Levels in North Carolina Schools: Comparison of Integrated ... using integrated pest management (IPM) to control cockroaches ...
... has implicated machinery that maintains the flow of potassium in ... Expression of a previously unknown form of a key such ... normal in the brain memory hub of people with the ... variation. An extensive series of experiments suggest that ...
... May 5, 2009 Researchers at the Hebrew University ... the tumor-risk factor in utilizing human embryonic stem cells. ... the promising field of stem cell therapy. ... to all cells of the mature human body (and ...
Cached Biology News:Flow of potassium into cells implicated in schizophrenia 2Flow of potassium into cells implicated in schizophrenia 3Hebrew University researchers neutralize tumor growth in embryonic stem cell therapy 2
(Date:9/14/2014)... functions in a wide variety of ways, including by ... can take on another form and perform no or ... wrongly can cause serious diseases such as Alzheimer,s, Parkinson,s ... a tendency to "infect" other molecules of the same ... plaques. These amyloids can damage cells and tissues and ...
(Date:9/13/2014)... September 13, 2014 Boehringer Laboratories Inc., ... is proud to announce the successful broadcast of a ... surgeons Leonardo Claros, MD, FACS, FAMBS, and Maher El ... Gastrectomy Calibration System. , This sleeve gastrectomy surgery ... of more than four hundred surgeons from around the ...
(Date:9/12/2014)...   Arthur Kay , the 23-year-old British founder ... Lottery Green Challenge 2014. The jury, chaired by ... at the final in Amsterdam ... Kay,s company uses a patented process to upcycle waste ... biomass pellets, used for powering buildings and transport systems. ...
(Date:9/12/2014)... , Sept. 12, 2014 Research ... "Global Dry Film Photoresist Industry Report 2014" ... Dry Film Photoresist Industry Report 2014 is a professional ... global dry film photoresist industry . The ... definitions, classifications, applications and industry chain structure. The dry ...
Breaking Biology Technology:Measuring modified protein structures 2Measuring modified protein structures 3Boehringer Laboratories, Inc. Announces Live Surgery Using Innovative System to Calibrate Sleeve Gastrectomy 2Green Startup Bio-Bean Wins $680,000 in Postcode Lottery Green Challenge 2Green Startup Bio-Bean Wins $680,000 in Postcode Lottery Green Challenge 3Global Dry Film Photoresist Industry Report 2014 2
... privately held,medical device firm, announced that it has successfully ... Crux IVC Filter. The filter, used to,prevent an often ... Center by David Rosenthal, Chief of Vascular Surgery. Every,year ... PE and,between 120,000 - 150,000 die as a result. ...
... Influenza ... Testing, ... company developing rapid molecular diagnostics and detection,systems, announces a EUR3 million ... The award will fund the,development and validation of a fully automated, ...
... More Than Doubles Assets Under Management, UTRECHT, The ... European venture capital firm, today announced,the closing of its ... II (GHC II). The new fund, which is Gilde,s ... raised to invest in European,healthcare opportunities. GHC II was ...
Cached Biology Technology:Crux Biomedical Announces First Successful U.S. Implant of Its New Retrievable Inferior Vena Cava (IVC) Filter 2Enigma Diagnostics Announces a European Commission Award of EUR3 Million to Fund the Development of a Point of Care Platform for the Rapid Diagnosis of Influenza Infections 2Gilde Healthcare Partners Closes EUR 150 Million European Healthcare Venture Fund 2
Mouse monoclonal [BC-4] to Aggrecan xxPEN ( Abpromise for all tested applications). entrezGeneID: 176 SwissProtID: P16112...
... molecular screening, low melting point agarose where ... is recommended for separation of nucleic acids ... PCR products. Micro ABgarose is also suited ... for blotting techniques. At a 3% concentration, ...
Rabbit polyclonal to Nck alpha ( Abpromise for all tested applications). entrezGeneID: 4690 SwissProtID: P16333...
Sheep polyclonal to Salmonella Thomasville ( Abpromise for all tested applications). Antigen: Native Salmonella thomasville...
Biology Products: