Navigation Links
Cold sore virus might play role in Alzheimer's disease

which makes people less likely to get the disease; and some had no ApoE gene at all.

The team found that the virus infiltrates brain cells about the same no matter which gene is involved. But they found that the subsequent activity level of the virus generally mirrored the disease-causing potential of the gene. They found that in animals with the ApoE-4 gene, the virus is less likely to be in the quiet, latent stage of its life cycle, suggesting it has more of an opportunity to replicate. In animals with the ApoE-2 gene, the virus was less active.

The work suggests that ApoE-4 may alter the balance between the HSV life cycle forms. It's possible that the ApoE gene works as a sort of bodyguard that tries to keep cells safe from herpes, perhaps by facilitating latency. Somehow the ApoE-2 version is extremely effective at keeping the virus at bay, while in this study, the ApoE-4 version wasn't any more effective than not having an ApoE gene at all.

The ApoE gene is well known to Alzheimer's researchers. The gene, which normally plays a role in ferrying cholesterol around the body, is associated with both the cellular tangles and amyloid plaques that are found in the brains of patients with the disease. Researchers have found several ways in which the gene might make a person vulnerable to getting a disease like Alzheimer's. In people with the ApoE-4 gene, brain cells don't seem to recover as well from injury, and the cells don't form new connections as well as cells equipped with either ApoE-2 or ApoE-3. Other scientists have shown that the gene plays a role in clearing toxic amyloid beta from the brain.

"Just how ApoE-4 makes people vulnerable to Alzheimer's disease isn't resolved at all," said Federoff, who is director of the University's Center for Aging and Developmental Biology. "It may be that it works in multiple ways."

The team is exploring different ways that herpes might affect the development of Alzheimer's
'"/>

Source:University of Rochester Medical Center


Page: 1 2 3 4

Related biology news :

1. Association of herpesvirus with lung disorder questioned
2. Topical treatment shown to inhibit HIV and herpes simplex virus infection
3. Elusive HIV shape change revealed; Key clue to how virus infects cells
4. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
5. Live Recombinant Adenovirus Vaccine Technique Explored
6. Marburg virus disease in Angola - update
7. Studies reveal methods viruses use to sidestep immune system
8. Norovirus, AIDS vaccine and Hepatitis Virus
9. Epstein-Barr virus protein crucial to its role in blood cancers
10. Live vaccines more effective against horse herpes virus
11. Turning viruses into allies against cancer
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cold sore virus might play role Alzheimer disease

(Date:8/21/2014)... A new study of American singles found that ... the highest orgasm rates. On average, men experience ... sexual orientation making little difference. For women, however, ... experience orgasm 62.9 percent of the time during ... pattern varies with women,s sexual orientation, with lesbian ...
(Date:8/21/2014)... 2014 /PRNewswire-iReach/ -- LiveScan Service Provider  Binary ... a partnership with Gabriel Health Institute, one of ... Certified Nursing Assistant preparatory schools. The agreement ... member of Binary,s LiveScan service provider,s owner/operator team; ... its service capabilities by widening the service ...
(Date:8/21/2014)... of the water window? It consists of radiations in ... absorbed by the water in biological tissues. New theoretical ... radiations within the water window. These could be the ... image of the biological samples or to be used ... the physical mechanism needed to efficiently generate the harmonic ...
Breaking Biology News(10 mins):Orgasm rates for single women less predictable than men's, vary by sexual orientation 2Orgasm rates for single women less predictable than men's, vary by sexual orientation 3Orgasm rates for single women less predictable than men's, vary by sexual orientation 4LiveScan Provider Binary Biometrics Announces Partnership with Preeminent CNA School, Gabriel Health Institute to Expand Services in Orlando Region 2LiveScan Provider Binary Biometrics Announces Partnership with Preeminent CNA School, Gabriel Health Institute to Expand Services in Orlando Region 3Water window imaging opportunity 2
... NEW YORK (July 27, 2011) A paper ... illegal trade in wildlife parts conducted by organized crime, coupled with antiquated ... and elephants on a scale never before seen. , ... June 7 on the online issue of the journal Oryx , ...
... gastric bypass, the most common type of bariatric surgery ... effective therapy for morbid obesity. Patients who undergo this ... small pouch and connected to the middle of the ... the reasons behind this surgery,s success have been unclear. ...
... low-birth-weight children, the rates of chronic health conditions overall, and ... and 14 years, although the rate of obesity did increase, ... JAMA . Changes in perinatal care in the ... (weight less than 2.2 lbs.). "The school-aged outcomes ...
Cached Biology News:Organized crime is wiping out wildlife 2Study suggests weight loss from gastric bypass may be partly due to dietary fat aversion 2Study suggests weight loss from gastric bypass may be partly due to dietary fat aversion 3Rate of chronic health problems for low-birth-weight children does not increase in adolescence 2
(Date:8/22/2014)... Surrey have discovered how the receptors responsible for contractions ... The new study, published today in The FASEB ... turn regulates the cycle of all cells in the ... local biological clock and its control are weakened in ... bladder physiology and ageing. , While currently ...
(Date:8/22/2014)... investigated for application as catalysts, sensors, drug ... in photonics and molecular electronics. Gaining knowledge ... physical and chemical properties, has been challenging. ... demonstrated that high-resolution electron microscopy can be ... which all gold atoms are observed. The ...
(Date:8/22/2014)... , Aug. 22, 2014 Research and ... "Global and China Gel Permeation Chromatography (GPC) Industry Report ... The Global and China Gel Permeation Chromatography (GPC) Industry ... current state of the global gel permeation chromatography industry ... report provides a basic overview of the industry including ...
(Date:8/22/2014)... August 22, 2014 Nerium International, ... is in the spotlight again. Nerium will showcase ... its NeriumFirmTM Body Contouring Cream to Hollywood’s elite ... Creations during the 66th Primetime Emmy® Awards. , ... extract, third-party clinical trials show that NeriumAD night ...
Breaking Biology Technology:Treatment for overactive bladder and irritable bowel syndrome advanced through pioneering research 2A breakthrough in imaging gold nanoparticles to atomic resolution by electron microscopy 2Global and China Gel Permeation Chromatography (GPC) Industry Report 2014 2Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 2Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 3
... (Nasdaq: GENR ) today announced that Jack Armstrong, ... present at the 2007,RBC Capital Markets Healthcare Conference. The ... of diabetes and obesity, entitled,"The Pharmaceutical Sweet Spot: Diabetes ... Thursday, December 13 at 10:00 a.m. ET., ...
... MYL ),today announced that Mylan Pharmaceuticals Inc. has ... (FDA) for its,Abbreviated New Drug Application (ANDA) for Lamotrigine ... Lamotrigine Tablets are the generic version of GlaxoSmithKline,s,Lamictal(R) ... the 12 months ending Sept. 30, 2007., Mylan ...
... LUMEDX Corporation, the market,leader in providing fully ... Performance Management System(TM),cardiology software that translates complex ... actionable information. CardioManager,s,performance dashboards and on-demand reporting ... and the ability to drill down for ...
Cached Biology Technology:New Cardiology Software Helps Heart Centers Manage for Optimal Clinical Performance 2
... continuous vertical flow of 99.99% particle-free air ... standards , Stainless steel enclosure ... , Large, ergonomically sloped polycarbonate viewing ... filling machines or other large process equipment ...
... biocompatibility testing at various temperatures, this ... through a clean heating unit to ... to 140F. Transparent panels allow full ... easy access to the work area. ...
Ideal for chemical processing that requires downward flow of exhaust fumes. Powderful 1200 CFM blower draws fumes into sub-surface bonded charcoal filter for safe removal of organic vapors (final HEP...
... The Label IT siRNA Tracker Intracellular Localization ... directly label and deliver siRNA, of your ... for in vitro tracking experiments. Subcellular localization ... can be monitored following introduction of the ...
Biology Products: