Navigation Links
Cold sore virus might play role in Alzheimer's disease

ng a correlation between herpes and Alzheimer's. She has shown that Alzheimer's patients who have the ApoE-4 form of the gene have more herpes DNA in the brain regions that are affected by Alzheimer's, compared to Alzheimer's patients who also have herpes but who have a different form of the ApoE gene. And she has shown that people with the ApoE-4 version of the gene who are infected with herpes are more likely to get Alzheimer's disease than people infected with herpes who have a different form of the ApoE gene, or than people who have the ApoE-4 gene but who don't have herpes.

Other scientists have found that a herpes infection is active more often ?causing the tell-tale cold sores around the mouth ?in the 25 percent of people who have a copy of the ApoE-4 gene. In other words, people who are frequently troubled by cold sores are more likely to have the gene that makes them more vulnerable to Alzheimer's disease.

Cold sores that come and go are the outward sign of the two different phases of the virus's life cycle. Herpes simplex is a chronic infection that lives in a person for a lifetime, periodically flaring up in a "lytic" phase where it causes cell damage, then retreating and seeking safe harbor within the body's nerves in a "latent" phase. The virus spends most of its time in the latent phase, sequestered in cells, not active and not replicating. But occasionally, when triggered by factors like stress, fatigue, certain foods, or even sunlight, the virus becomes active, traveling from its hiding places in the nervous system to cells around the mouth, damaging cells and causing cold sores.

It was this cycle of activity and latency that Miller and Federoff focused on while looking at the brain cells of mice with different forms of the ApoE gene. They looked at four groups of mice: Some had ApoE-3, which is what the majority of people carry; some had ApoE-4, which in people makes them more likely to get Alzheimer's; some had ApoE-2,
'"/>

Source:University of Rochester Medical Center


Page: 1 2 3 4

Related biology news :

1. Association of herpesvirus with lung disorder questioned
2. Topical treatment shown to inhibit HIV and herpes simplex virus infection
3. Elusive HIV shape change revealed; Key clue to how virus infects cells
4. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
5. Live Recombinant Adenovirus Vaccine Technique Explored
6. Marburg virus disease in Angola - update
7. Studies reveal methods viruses use to sidestep immune system
8. Norovirus, AIDS vaccine and Hepatitis Virus
9. Epstein-Barr virus protein crucial to its role in blood cancers
10. Live vaccines more effective against horse herpes virus
11. Turning viruses into allies against cancer
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cold sore virus might play role Alzheimer disease

(Date:10/16/2014)... and Mary,s Virginia Institute of Marine Science have ... Protection Agency to identify the streams and wetlands ... tools to help local governments and citizens conserve ... on a dataset of tidal-marsh observations first gathered ... this historical baseline can today,s researchers accurately map ...
(Date:10/16/2014)... monocultures can be cultivated efficiently, they are anything ... caused by monoculture cultivation is becoming increasingly evident. ... crop form and are regarded as the sole ... – quite wrongfully, finds Bernhard Schmid, an ecology ... a novel form of agriculture and forestry. After ...
(Date:10/16/2014)... , October 16, 2014 NXT-ID, Inc. (NASDAQ: ... "Company"), a biometric authentication company focused on the growing ... edge technologies including Wocket™, the Smart Wallet, at the ... FiRe is a leading global conference on the intersection ... by Mark Anderson , founder and publisher of ...
Breaking Biology News(10 mins):EPA grant will help localities conserve headwater wetlands 2EPA grant will help localities conserve headwater wetlands 3Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3
... weekend warriors: the simple act of exercise and not ... a new University of Florida study finds. People ... gaining strength or boosting cardiovascular fitness feel just as ... said Heather Hausenblas, a UF exercise psychologist. Her study ...
... sees the launch of Ensembl Plants a ... by the European Molecular Biology Laboratory,s European ... Spring Harbor Laboratory, USA. Ensembl Plants allows researchers ... genome-scale experiments in different plant species. By pinpointing ...
... disease and other diet related health problems received a 4 ... projects. The projects, taking place in universities and research institutes ... publicly-funded Research Councils and 15 companies. This means the research ... in our society but in a way that the food ...
Cached Biology News:UF study: Exercise improves body image for fit and unfit alike 2UF study: Exercise improves body image for fit and unfit alike 3New portal for plant genomics will support research into improved crops 2Public sector and industry unite to attack obesity and heart disease 2
(Date:10/25/2014)... 2014 According to new market ... Center Types (Colocation, Enterprise, Telecom), by Design Types ... Tier 2, Tier 3, Tier 4) - Global ... segments the Data Center Construction Market into various ... revenues. This research report also identifies the factors ...
(Date:10/25/2014)... This research report “Biodegradable Plastics Market by Type ... PCL), by Application (Packaging, Fibers, Agriculture, Injection Molding) ... and segments the global biodegradable plastics market with ... and value. , Browse 75 Market Data Tables ... in-depth TOC on “Biodegradable Plastics Market by Type, ...
(Date:10/25/2014)... A new way to produce engineered skin ... skin grafting technologies, it also speeds up the healing ... in the October issue of STEM CELLS Translational Medicine, ... that result from severe burns and chronic wounds. , ... elements. These wounds heal by contraction, with epithelization (the ...
(Date:10/25/2014)... and NEW YORK , ... (OTCQB: ACCPD), formerly Access Pharmaceuticals, Inc. (ACCP), a ... announced it has implemented a 1-for-50 reverse split ... of trading on Friday, October 24, 2014. PlasmaTech,s ... under new CUSIP number 72754H109 and temporary ticker ...
Breaking Biology Technology:Data Center Construction Market Worth $22.73 Billion by 2019 - New Report by MarketsandMarkets 2Data Center Construction Market Worth $22.73 Billion by 2019 - New Report by MarketsandMarkets 3Data Center Construction Market Worth $22.73 Billion by 2019 - New Report by MarketsandMarkets 4Biodegradable Plastics Market Projected to $3,476.87 Million by 2019 - Report by MarketsandMarkets 2Biodegradable Plastics Market Projected to $3,476.87 Million by 2019 - Report by MarketsandMarkets 3Biodegradable Plastics Market Projected to $3,476.87 Million by 2019 - Report by MarketsandMarkets 4New engineering method shows promise for faster healing, more cosmetically appealing skin grafts 2New engineering method shows promise for faster healing, more cosmetically appealing skin grafts 3PlasmaTech Biopharmaceuticals, Inc. Announces Reverse Stock Split, Ticker Change and Launches New Corporate Website 2
... DIEGO -- In the Sept 9, 2010 issue of ... of concept studies that show its proprietary compound, NGP ... Alzheimer,s disease (AD) in a transgenic mouse model. ... the gamma secretase modulator (GSM) compound from NGP, the ...
... GAITHERSBURG, Md. Using a one-of-a-kind instrument designed and ... (NIST), an international team of researchers have "unveiled" a ... in graphene can split up into an unexpected and ... low temperatures and extremely high magnetic fields. Published in ...
... THE WOODLANDS, Texas, Sept. 9 Lexicon Pharmaceuticals, ... company focused on discovering breakthrough treatments for human disease, ... president and chief executive officer, will present at the ... 16, 2010 at 9:10 a.m. Eastern Time. ...
Cached Biology Technology:Neurogenetic studies show proprietary compound reduces brain plaques linked to Alzheimer's 2NIST researchers hear puzzling new physics from graphene quartet's quantum harmonies 2NIST researchers hear puzzling new physics from graphene quartet's quantum harmonies 3Lexicon to Present at Stifel Nicolaus Healthcare Conference 2