Navigation Links
Coated nanoparticles solve sticky drug-delivery problem

Johns Hopkins, had established that some viruses are able to make their way through the human mucus barrier. Hanes and his colleagues decided to look for a chemical coating that might mimic the characteristics of a virus.

"We found that the viruses that got through had surfaces that were attracted to water, and they had a net neutral electrical charge," said Samuel K. Lai, a Johns Hopkins chemical and biomolecular engineering doctoral student from Canada and Hong Kong who was lead author of the journal article. "We thought that if we could coat a drug-delivery nanoparticle with a chemical that had these characteristics, it might not get stuck in the mucus barrier."

To make their nanoparticles behave like viruses, the researchers coated them with polyethylene glycol, PEG, a non-toxic material commonly used in pharmaceuticals. PEG dissolves in water and is excreted harmlessly by the kidneys.

The researchers also considered the size of their nanoparticles. Previous studies indicated that even if nanoparticles did not stick to the mucus, they might have to be smaller than 55 nanometers wide to pass through the tiny openings in the human mucus mesh. (A human hair is roughly 80,000 nanometers wide.) Using high-resolution video microscopy and computer software, the researchers discovered that their PEG-coated 200-nanometer particles could slip through a barrier of human mucus.

They then conducted further tests to see how large their microscopic drug carriers could be before they got trapped in the mesh. Larger nanoparticles are more desirable because they can release greater amounts of medicine over a longer period of time. "We wanted to make the particles as large as possible," said Hanes, who also serves as director of therapeutics for the Institute for NanoBioTechnology at Johns Hopkins. "The shocking thing was how fast the particles that were 500 nanometers wide moved through the mucus mesh. The work suggests that the openings
'"/>

Source:Johns Hopkins University


Page: 1 2 3

Related biology news :

1. Probing the promise and perils of nanoparticles
2. Novel gene-silencing nanoparticles shown to inhibit Ewings sarcoma
3. Using nanoparticles, in vivo gene therapy activates brain stem cells
4. NJIT study shows nanoparticles could damage plant life
5. Gold nanoparticles could improve antisense cancer drugs
6. MIT nanoparticles may help detect, treat tumors
7. Quantum dots reviewed -- Could these nanoparticles hold the cure to cancer?
8. Electric jolt triggers release of biomolecules, nanoparticles
9. U-M researchers use nanoparticles to target brain cancer
10. Gold nanoparticles prove to be hot stuff
11. Widely used iron nanoparticles exhibit toxic effects on neuronal cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Coated nanoparticles solve sticky drug delivery problem

(Date:8/5/2015)... According to a new market research report, ... (BFSI, Airport, IT & Telecom, Utilities, Education, Defense & ... published by MarketsandMarkets, defines and segments the Physical Identity ... global PIAM Market is estimated to grow from $272.2 ... a CAGR of 14.9 % from 2014 to 2019. ...
(Date:8/3/2015)... , Aug. 3, 2015 Synaptics, Inc. ... interface solutions, today announced that members of the executive ... the Pacific Crest Global Technology Leadership Forum on Tuesday, ... conference will be held at the Sonnenalp Resort in ... The presentation may include forward-looking information. An audio webcast ...
(Date:7/31/2015)... 2015 La 10 th International Conference on ... BGI del 22 al 25 de octubre de 2015 en ... la conferencia celebra su décimo aniversario. Desde su inauguración en ... las reuniones anuales más influyentes del mundo en el campo ... entusiastas y mejores a nivel científico. ICG-10 ...
Breaking Biology News(10 mins):Physical Identity and Access Management Market Worth $546.2 Million by 2019 2Physical Identity and Access Management Market Worth $546.2 Million by 2019 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 4La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 2La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 3
... forecasts that predict what the coming winter may ... scientists have developed the first long-term forecast of ... "Being able to predict future phytoplankton blooms, ocean ... said Samantha Siedlecki, a research scientist at the ...
... been shown to increase the pigment in their skin in response ... today in Nature journal, Scientific Reports , reveals that not ... incurring DNA damage in their skin just like us, they also ... older. Experts in the response of skin to UV radiation ...
... University researcher will receive $1.3 million over the next ... Digestive and Kidney Diseases (NIDDK) for research that will ... informing the development of novel treatments to reverse the ... million people worldwide suffer from type 2 diabetes--a number ...
Cached Biology News:New ocean forecast could help predict fish habitat 6 months in advance 2New ocean forecast could help predict fish habitat 6 months in advance 3Whales feel the (sun)burn! 2Whales feel the (sun)burn! 3Type 2 diabetes study to examine role amylin plays in disease 2
(Date:8/27/2015)... ... August 27, 2015 , ... Proove Biosciences, a commercial ... relationship of genetics and hypertension at the International Academy of Cardiology ... Columbia, Canada. The event, which boasts an extensive overview of the latest research ...
(Date:8/26/2015)... ... August 26, 2015 , ... Lee Biosolutions, a global biotech ... manufacture of highly valued cardiac markers used in early detection of heart disease ... chemistry has led to the development and commercialization of important cardiac biomarkers used ...
(Date:8/26/2015)... , August 26, 2015 Israel Proves Its ... wins 1 st place  Wayerz comes in 5 ... Israel by venture capital fund JVP, with Chinese ... US, China , Israel , ... .  Impressive achievement for the Israeli representatives in the ...
(Date:8/26/2015)... ... 2015 , ... PRC Clinical, a Clinical Trial Management Expert CRO, ... in southern California. The Clinical Trial Management Expert CRO seeks to introduce more California-based ... , Stem Cell Meeting on the Mesa on October ...
Breaking Biology Technology:Proove Biosciences Presents Ground-Breaking Data on Genetics and Heart Disease at 20th World Congress on Heart Disease 2Proove Biosciences Presents Ground-Breaking Data on Genetics and Heart Disease at 20th World Congress on Heart Disease 3Lee Biosolutions Announces Increased Investment in the Development and Manufacturing of Biomarkers Used in Early Detection Of Heart Disease 2Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 2Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 3Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 4Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 5Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 6PRC Clinical To Attend Major Industry Conferences And Meet Sponsor Companies In The San Diego Biotech Hub 2PRC Clinical To Attend Major Industry Conferences And Meet Sponsor Companies In The San Diego Biotech Hub 3
... N.Y., Nov. 11 Nikon Instruments Inc. has,provided ... Clemson,University,s College of Agriculture, Forestry and Life Sciences ... The facility will,be the first of its kind ... most,technologically advanced systems Nikon Instruments Inc. has installed,anywhere ...
... --,China Biologic Products, Inc. (OTC Bulletin Board: CBPO) ... pharmaceutical companies in the,People,s Republic of China ("PRC"), ... at 10:00 a.m. EST on Thursday, November 13, ... Hosting the call will be Mr. Colin Zhao, ...
... A1c testing using dried blood spot,specimens, BASKING RIDGE, ... of Hooper Holmes (Amex: HH ), today announced,certification ... Standardization Program (NGSP)., Heritage Labs uses two blood ... specimens and the other for testing dried blood,spots (DBS), ...
Cached Biology Technology:Nikon Instruments Provides Donation to Help Clemson University Start New Core Microscopy Facility 2Nikon Instruments Provides Donation to Help Clemson University Start New Core Microscopy Facility 3China Biologic Products Announces Third Quarter 2008 Results Conference Call 2Heritage Labs Announces A1c Test Certification Milestone 2Heritage Labs Announces A1c Test Certification Milestone 3
Best pricing for 100mg-1.0g scales. Phosphopeptides are our specialty....
... The JNK (c-Jun NH2-terminal kinase) signal ... identified MAP kinase pathways in mammals. ... to environmental stress, is associated with ... and is implicated in the immune ...
... is an automated, two-dimensional fractionation system for ... Part of Beckman Coulters ProteomeLab family of ... just hours. The system effectively resolves ... lysates, addressing a key challenge in todays ...
... The ProteomeLab PA 800 is ... Part of Beckman Coulters ProteomeLab ... offers a comprehensive range of automated ... determination, peptide mapping, isoelectric focusing, carbohydrate ...
Biology Products: