Navigation Links
Clues to gene expression in cystic fibrosis will guide research

Genetics tests could help provide cystic fibrosis (CF) patients with targeted treatment in future, pilot study authors suggest. Results from a French clinical trial published today in BMC Medicine show how a small percentage of CF sufferers with a rare genetic stop mutation responded positively to gentamicin treatment.

Aleksander Edelman and Isabelle Sermet-Gaudelus of Faculté de Médicine Necker in Paris led collaborators from several French institutions studying how the antibiotic gentamicin affected CF patients with a stop mutation. The team used a dual reporter gene assay first in vitro and then in CF patients. The study found that a small subgroup of patients with the Y122X mutation, found mainly in inhabitants of Reunion island, responded to gentamicin treatment.

Cystic fibrosis is caused by mutations in the gene that encodes the Cystic Fibrosis Transmemrane Conductance Regulator (CFTR) protein. Over 1500 mutations have been described since this gene’s discovery. Premature stop mutations, which includeY122X, are found in around 10% of CF patients. Gentamicin reversed stop codons in the Y122X gene, and helped restore the CFTR protein, improving patients?respiration.

Gentamicin itself may not be an ideal drug option, as it may cause serious side effects for some patients, including ear and kidney damage. The authors suggest that other drugs, such as amikacin or PTC124, with a comparable mode of action and fewer side effects, may have treatment potential. The in vitro method used to predict the trial’s outcome could be a first step to developing treatments effective for patients with CF and other diseases where premature stop codons play a role.
'"/>

Source:BioMed Central


Page: 1

Related biology news :

1. Research on Worms Yields Clues on Aging
2. New Clues Add 40,000 Years to Age of Human Species
3. Clues to breast cancer hidden inside stem cells
4. Renegade RNA -- Clues to cancer and normal growth
5. Alcohols effects on gene expression in the central nervous system
6. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
7. Towards precise classification of cancers based on robust gene functional expression profiles
8. Expression Project for Oncology (expO) completes first phase of standardized gene expression analyses
9. Study: homemade gene expression technology unreliable
10. Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression
11. Agilent Technologies releases probe sequence, annotation information for all its commercial gene expression microarrays
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Clues gene expression cystic fibrosis will guide research

(Date:5/24/2013)... ecosystems can get messy, especially when trying to predict ... change. , In a new paper published this ... National Academy of Sciences , researchers from the University ... the very heart of a popular way to predict ... changes may impact biodiversity, researchers like Jessica Blois and ...
(Date:5/24/2013)... 2013 A frequently expressed concern in the ongoing public ... vegetables, especially those that are nutrient dense. A ... Beans Provide Most Nutrients Per Penny," published in the ... one of the best nutritional values in the produce ... penny than most other raw vegetables and delivering one ...
(Date:5/24/2013)... growing open-access publishers, today announces the launch of a ... broad scope journal covering all specialties, Frontiers in ... platform for the research community to publish high quality ... interactive peer-review enables fast, fair and constructive review of ... three months from submission to final decision for a ...
Breaking Biology News(10 mins):Understanding the past and predicting the future by looking across space and time 2New research shows that potatoes provide one of the best nutritional values per penny 2Frontiers launches new open-access journal in physics 2Frontiers launches new open-access journal in physics 3
... Philadelphia, PA -- The Academy of Nutrition and Dietetics ... for Medicare and Medicaid Services (CMS) to expand coverage ... hypertension, obesity, and cancer, as part of the CMS ... conditions can be controlled or treated with medical nutrition ...
... RIVERSIDE, Calif. Four researchers at the University of California, ... the Advancement of Science ( AAAS ). Including this year,s ... have been recognized with AAAS Fellow distinction is 194. ... members by their peers. This year AAAS gave this honor ...
... what midwives view as the overly medicalized way hospitals ... the message that women,s bodies know best. The ... that home birth is about female empowerment, strengthening relationships ... put mothers in control, with the ultimate goal of ...
Cached Biology News:The Academy of Nutrition and Dietetics advocates for expanded nutritional coverage under Medicare 2The Academy of Nutrition and Dietetics advocates for expanded nutritional coverage under Medicare 34 UC Riverside researchers receive national recognition 2Midwives use rituals to send message that women's bodies know best 2Midwives use rituals to send message that women's bodies know best 3
(Date:5/24/2013)... Dr. Ingrid Warmuth and Anamaria Newport, MHS, ... proud to announce an Open House at their Swedesboro location, ... June 8th from 10 AM to 2 PM. , ... and staff will be on hand to talk to people ... and provide complimentary cosmetic consultations. There will also be specials ...
(Date:5/24/2013)... May 24, 2013 In a ... industry suppliers will present technologies with applications in ... annual SPIE Optics and Photonics symposium ... SPIE, the international society for optics and ... multidisciplinary optical sciences and technology meeting in North ...
(Date:5/24/2013)... (PRWEB) May 24, 2013 Bed bug cases ... protect themselves from the looming higher risk of becoming the ... a new bed bug guideline. In the guide, the company ... and avoiding them while traveling. , According to ... an increase of bed bug infestation during summer: the warm ...
(Date:5/24/2013)... TEL AVIV, Israel , May 24, 2013 ... (NYSE MKT: NSPR), a leader in embolic protection stents, announced ... and Chief Executive Officer, and Craig Shore ... Benchmark Company, LLC One-on-One Investor Conference on Thursday May 30, ... Milwaukee, WI. The format of ...
Breaking Biology Technology:See What’s in Earth’s Future ? and Out in Space Now ? at SPIE Optics and Photonics 2See What’s in Earth’s Future ? and Out in Space Now ? at SPIE Optics and Photonics 3See What’s in Earth’s Future ? and Out in Space Now ? at SPIE Optics and Photonics 4Steps for Getting Rid of Bed Bugs without Using Chemicals and Avoiding Them While Traveling Enumerated by My Cleaning Products in Its Latest Post 2Steps for Getting Rid of Bed Bugs without Using Chemicals and Avoiding Them While Traveling Enumerated by My Cleaning Products in Its Latest Post 3InspireMD To Participate In Benchmark Investor Conference On May 30th 2InspireMD To Participate In Benchmark Investor Conference On May 30th 3InspireMD To Participate In Benchmark Investor Conference On May 30th 4
... Created Role of Senior Vice President of ... Philip R. Licari to Step Down as Chief Operating Officer upon Closing ... ... ), the manufacturer of the NxStage System One (TM),portable kidney dialysis machine, today ...
... SAN CARLOS, Calif., Aug. 29 Nektar,Therapeutics (Nasdaq: ... Lingnau has been,appointed to serve on its board ... with over 35 years of experience in,corporate management, ... to Nektar extensive pharmaceutical development and,commercialization experience at ...
... Colo., Aug. 29 Pharmion Corporation,(Nasdaq: PHRM ... Drug Administration,(FDA) has granted Fast Track designation for ... Fast Track programs are designed to facilitate ... that are intended to treat serious or,life-threatening conditions ...
Cached Biology Technology:NxStage Medical Provides Update on Medisystems Acquisition 2NxStage Medical Provides Update on Medisystems Acquisition 3NxStage Medical Provides Update on Medisystems Acquisition 4NxStage Medical Provides Update on Medisystems Acquisition 5Nektar Therapeutics Appoints Lutz Lingnau as New Board Member 2Nektar Therapeutics Appoints Lutz Lingnau as New Board Member 3Pharmion's Oral Azacitidine Granted Fast Track Status for Myelodysplastic Syndromes 2Pharmion's Oral Azacitidine Granted Fast Track Status for Myelodysplastic Syndromes 3Pharmion's Oral Azacitidine Granted Fast Track Status for Myelodysplastic Syndromes 4Pharmion's Oral Azacitidine Granted Fast Track Status for Myelodysplastic Syndromes 5Pharmion's Oral Azacitidine Granted Fast Track Status for Myelodysplastic Syndromes 6
Glucagon-like peptide-1 (GLP-1 (1-36) amide)...
... LC Sciences provides a comprehensive microarray ... regulatory/functional RNA embedded within non-coding RNAs ... and proprietary probe design, which enables ... of small RNAs (1). This comprehensive ...
... LC Sciences provides a comprehensive ... protein kinase substrate (PKS) peptide microarrays ... proteomic scale kinase profiling, quantitative measurement ... discovery research. This comprehensive service includes ...
... Sciences provides a unique new tool, OligoMix ... serving diverse needs in genomics, proteomics, synthetic ... is a MIXTURE of a large number ... in a single microtube. OligoMix is made ...
Biology Products: