Navigation Links
Clues to gene expression in cystic fibrosis will guide research

Genetics tests could help provide cystic fibrosis (CF) patients with targeted treatment in future, pilot study authors suggest. Results from a French clinical trial published today in BMC Medicine show how a small percentage of CF sufferers with a rare genetic stop mutation responded positively to gentamicin treatment.

Aleksander Edelman and Isabelle Sermet-Gaudelus of Faculté de Médicine Necker in Paris led collaborators from several French institutions studying how the antibiotic gentamicin affected CF patients with a stop mutation. The team used a dual reporter gene assay first in vitro and then in CF patients. The study found that a small subgroup of patients with the Y122X mutation, found mainly in inhabitants of Reunion island, responded to gentamicin treatment.

Cystic fibrosis is caused by mutations in the gene that encodes the Cystic Fibrosis Transmemrane Conductance Regulator (CFTR) protein. Over 1500 mutations have been described since this gene’s discovery. Premature stop mutations, which includeY122X, are found in around 10% of CF patients. Gentamicin reversed stop codons in the Y122X gene, and helped restore the CFTR protein, improving patients?respiration.

Gentamicin itself may not be an ideal drug option, as it may cause serious side effects for some patients, including ear and kidney damage. The authors suggest that other drugs, such as amikacin or PTC124, with a comparable mode of action and fewer side effects, may have treatment potential. The in vitro method used to predict the trial’s outcome could be a first step to developing treatments effective for patients with CF and other diseases where premature stop codons play a role.
'"/>

Source:BioMed Central


Page: 1

Related biology news :

1. Research on Worms Yields Clues on Aging
2. New Clues Add 40,000 Years to Age of Human Species
3. Clues to breast cancer hidden inside stem cells
4. Renegade RNA -- Clues to cancer and normal growth
5. Alcohols effects on gene expression in the central nervous system
6. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
7. Towards precise classification of cancers based on robust gene functional expression profiles
8. Expression Project for Oncology (expO) completes first phase of standardized gene expression analyses
9. Study: homemade gene expression technology unreliable
10. Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression
11. Agilent Technologies releases probe sequence, annotation information for all its commercial gene expression microarrays
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Clues gene expression cystic fibrosis will guide research

(Date:7/11/2014)... -- Research and Markets has announced the ... Industry Analysis Size Share Growth Trends and Forecast to ... http://photos.prnewswire.com/prnh/20130307/600769 The rising number ... for high level security in both private and public ... username and passwords, tokens etc. are vulnerable to attacks. ...
(Date:7/11/2014)... de Janeiro, Brazil- In the brains of all ... that allows an electric or chemical signal to ... Chemical synapses, which are the most abundant type ... Synapse formation is crucial for learning, memory, perception ... inhibitory synapses critical for brain function. For ...
(Date:7/10/2014)... , June 27, 2014  The American Academy ... Institute of Standards and Technology (NIST) and the ... academic research and forensic science expert members to ... is an element of the NIST,s Organization of ... among the first appointments made to the new ...
Breaking Biology News(10 mins):International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019 2Blame it on the astrocytes 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 3
... reduces spoilage explains a scientist at the Society for ... explains how ozone treatment could be a safe, effective ... foods. It is estimated that up to 30% ... spoilage. Dr Singleton from Newcastle University explains that low ...
... being able to develop a computer model of the brain ... functions of nerve cells in the brain together for the ... in the neuroscience known as ,connectomics,. With parallels to genomics, ... the brain,s connections (known as ,synapses,). By mapping these connections ...
... Lee, a graduate student in Cornell University,s Dyson School of ... known as "the halo effect" for some time. Psychologists have ... of a person can be influenced by how we perceive ... the fact that a person has a positive attribute can ...
Cached Biology News:Ozone reduces fungal spoilage of fruits and vegetables 2Mapping the brain: New technique poised to untangle the complexity of the brain 2Mapping the brain: New technique poised to untangle the complexity of the brain 3The health halo effect: Don't judge a food by its organic label 2
(Date:7/10/2014)... OMICS Group’s 5th International conference and ... 2014 at Double Tree by Hilton Beijing, China is ... Analytical & Bioanalytical research methods only to facilitate improved ... occasion, Dr. Srinubabu Gedela, MD of OMICS Group Inc ... remarkable one in bringing a unique and international mix ...
(Date:7/10/2014)... POINT, Ind. , July 10, 2014 ... expanded its use of capnography for respiratory ... growing group of healthcare leaders in embracing ... measures how effectively patients are breathing and ... depression occurs. By measuring the amount of ...
(Date:7/10/2014)... Utah , July 10, 2014 /PRNewswire-iReach/ ... annotation and interpretation, today announced an agreement ... (NGS) analytics for Lineagen,s NextStep Dx ... of neurodevelopmental and neurological disorders, currently offers ... microarray (CMA) testing service used by healthcare ...
(Date:7/10/2014)... to the International Atomic Energy Agency (IAEA) the ... acquiring sufficient quantities of plutonium or highly enriched ... device. The IAEA also notes that most cases ... which can be challenging to detect with most ... appearing this week in the Journal of ...
Breaking Biology Technology:A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Sensitive detection method may help impede illicit nuclear trafficking 2
... , DURHAM, N.C., Nov. 27 Cromoz ... nanotube-based cancer drug delivery system in Hyderabad, India. The water-soluble ... allows for conjugation with cancer drugs, was developed in partnership ... nanotubes serves as a drug delivery vehicle with the ability ...
... of ultrasmall transistors and more powerful computer chips using ... after a key discovery by researchers at IBM, Purdue ... The researchers have learned how to create nanowires ... at the atomic level, which is a critical requirement ...
... ... of Canada , ... (Vocus) November 25, 2009 -- Ambassador to Speak at Economic Club of Canada., , , ... Invest in France Agency ,To view a biography of David Appia go to www.investinfrance.org ...
Cached Biology Technology:North Carolina Based Cromoz Inc. Launches Carbon Nanotechnology for Target Drug Delivery System in Cancer Treatment in Hyderabad, India 2Nanowires key to future transistors, electronics 2Nanowires key to future transistors, electronics 3French Ambassador for International Investment to Visit Toronto December 11 2
Monoclonal Antibody to GLP Immunogen: Ni-NTA purified truncated recombinant GLP expressed in E. Coli strain BL21 (DE3)...
...
Homo sapiens MEP50 protein, mRNA...
Co-precipitant is free of background polynucleotides,Dnases,Rnases, proteases. 20mg/ml...
Biology Products: