Navigation Links
Clues to breast cancer hidden inside stem cells

Stem cells and how to boost them is hot on the research agenda. But stopping them could be critical too, as evidence implicating stem cells in cancer is mounting.

In the human breast, up to 20 per cent of all tumours are now suspected to originate in stem cells. Now scientists from the Icelandic Cancer Society and the Faculty of Medicine, University of Iceland have grown three-dimensional breast cell cultures to reveal unexpected subtleties about these stem cells that could explain why they spawn malignancies.

These stem cells, Valgardur Sigurdsson remarked during the EuroSTELLS Conference in Venice, Italy (19-21 March), could become targets for cancer treatment, leading to new therapies that wipe out cancer at its source. The hope is that they might also become useful tools to test new drugs.

"People have long suspected there should be a stem cell population in the human breast gland," said Sigurdsson who is part of the ESF-funded team led by Thorarinn Gudjonsson. A 'virgin' breast, before pregnancy, is very different to a fully functioning, milk-producing breast. With lactation, the breast becomes fully differentiated, and once this stage is over, it involutes. This cycle of proliferation, differentiation and apoptosis also happens in every menstrual cycle and in a more dramatic form during pregnancy. "This caught our attention, and has driven our research," Sigurdsson pointed out.

Breast cancer almost always occurs in the luminal epithelial compartment, which is also where milk is produced. Perhaps it is not surprising then, that stem cells reside in this compartment. In 2002, Thorarinn Gudjonsson, successfully isolated cells from the human breast with stem cell properties.

Gudjonsson immortalised these cells and grew them in three dimensional matrix that mimics the real, living tissue. Biologists have long relied on 2-dimensional cell cultures as the basic tool of their trade. But there is a big difference between a fl
'"/>

Source:European Science Foundation


Page: 1 2

Related biology news :

1. Research on Worms Yields Clues on Aging
2. New Clues Add 40,000 Years to Age of Human Species
3. Clues to gene expression in cystic fibrosis will guide research
4. Renegade RNA -- Clues to cancer and normal growth
5. Viral DNA sequence a possible trigger for breast cancer
6. Used in a new way, RNA interference permanently silences key breast cancer gene
7. Biomarkers isolated from saliva successfully predict oral and breast cancer
8. Study reveals dramatic difference between breast cancers in US and Africa
9. Compounds in plastic packaging act as environmental estrogens altering breast genes
10. Alcohol consumption disrupts breastfeeding hormones
11. VCU Massey Cancer Center study shows enzyme linked to spread of breast cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Clues breast cancer hidden inside stem cells

(Date:7/10/2014)... , July 8, 2014 ... a new design win (DW). An Asian OEM has selected ... mass production start in August 2014.   FPC ... OEM, which has a planned date for start of mass ... ramp order of SEK 5M, for delivery in the first ...
(Date:7/10/2014)... the large, mainly tropical flowering plant family Melastomataceae (Meadow Beauty ... rely on bees for their pollination. Only about 100 are ... flowers of Axinaea appear in clusters of few ... different species are pink, yellow, orange or red. The stamens ... of their bulbous appendages. The pollination mechanism of Axinaea ...
(Date:7/10/2014)... popcorn or soap might not be ape friendly, and the ... analysis in the Cell Press journal Current Biology ... has already led to the conversion of Southeast Asian forest ... If guidelines are not put in place very soon, researchers ... into Africa will be bad news for great apes there ...
Breaking Biology News(10 mins):FPC Wins DW and Initial Ramp Order for FPC1021 Touch Sensor for Flagship Smartphone from Asian OEM 2Novel type of bird pollination mechanism discovered in South America 2Hunger for vegetable oil means trouble for Africa's great apes 2
... science has finally put to rest a 90-year-old mystery ... of a child,s escape from the firing squad. Genomic ... in cooperation with Institutions of Russian Academy ... have confirmed that human remains found in the ...
... warning signs of climate change in the upper atmosphere ... 2009 Tyler Prize for Environmental Achievement. The ... medals, will go to Richard Alley, professor of geosciences ... of atmospheric and climate sciences in the Scripps Institution ...
... from the satellite-based MIPAS and GOME-2 instruments, scientists ... species in the atmosphere. These new measurements will ... species and to improve simulations of stratospheric ozone ... (BrO) in the atmosphere some 20 years ago, ...
Cached Biology News:UMMS researchers publish DNA identification of czar's children 2UMMS researchers publish DNA identification of czar's children 3UMMS researchers publish DNA identification of czar's children 4Winners of Tyler environmental prize announced 2European satellites provide new insight into ozone-depleting species 2
(Date:7/10/2014)... July 10, 2014  Kainos Capital, a firm specializing ... announced that it has acquired the Slim-Fast brand from ... business. Terms of the transaction were not disclosed. ... replacement business that markets ready-to-drink shakes, powders, bars and ... and in the United Kingdom ...
(Date:7/10/2014)... WASHINGTON D.C., April 15, 2014 -- According to ... danger to nuclear security comes from terrorists acquiring ... (HEU) to construct a crude nuclear explosive device. ... illicit nuclear trafficking have involved gram-level quantities, which ... methods. , According to a new study appearing ...
(Date:7/10/2014)... psychiatric disorders has been extremely challenging because there are ... insufficient to cause disease. Now investigators reporting in the ... Cell Stem Cell describe a strategy that may ... other risk factors or environmental exposures to affect the ... genetic variant that may predispose individuals to schizophrenia. ...
(Date:7/10/2014)... the 1960s, theatergoers have shelled out for crude ... enhance their viewing experience. These basic devices, used ... three-dimensional reality, may soon be rendered obsolete with ... Tel Aviv University researchers. , TAU doctoral students ... developed highly efficient holography based on nanoantennas that ...
Breaking Biology Technology:Kainos Capital Acquires Slim-Fast From Unilever 2Sensitive detection method may help impede illicit nuclear trafficking 2New strategy could uncover genes at the root of psychiatric illnesses 2Projecting a 3-dimensional future 2Projecting a 3-dimensional future 3
... Microsoft Gold Certified Partner Provides Framework, for ... Solutions, ORLANDO, Fla., Feb. 26 ... software and services for health and,human services ... Certified Partner status in the Microsoft Partner ...
... Clinical ... ... Conference and Exhibition, Allscripts, the leading provider of,clinical software, connectivity and ... Cross Hospital has,selected the Allscripts Electronic Health Record to inform and ...
... MOUNTAINSIDE, N.J., Feb. 26 National Stem,Cell ... its President,Michael Cohen will present a Keynote Address, ... and Development Stage,Biotech Companies," at the Inaugural meeting ... & Careers in Stem Cell Science,February 28- 29, ...
Cached Biology Technology:Netsmart Technologies Announces Development Program on Microsoft for Local Public Health Clinic Management and Vital Records Software 2Netsmart Technologies Announces Development Program on Microsoft for Local Public Health Clinic Management and Vital Records Software 3Holy Cross Hospital Selects Allscripts Electronic Health Record 2Holy Cross Hospital Selects Allscripts Electronic Health Record 3Holy Cross Hospital Selects Allscripts Electronic Health Record 4National Stem Cell Holding, Inc. to Present Keynote Address at The Stem Cell Partnering Series Inaugural Meeting in San Diego 2National Stem Cell Holding, Inc. to Present Keynote Address at The Stem Cell Partnering Series Inaugural Meeting in San Diego 3
Topoisomerase I, isolated from wheat germ, is an enzyme capable of removing negative supercoils from covalently closed circular DNA (1)....
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5...
... Accession Number : NM_006225 Immunogen : ... corresponding to full length rat PLC delta ... NaCl, 0.05% sodium azide before the addition ... evaluated by immunoblot on RIPA lysates from ...
Request Info...
Biology Products: