Navigation Links
Clue found to Epstein-Barr virus' ability to form and sustain tumors

EBV encodes. They then infected human B cells with EBVs carrying various mutant EBNA-1s.

The analysis showed that one 25-amino acid segment within EBNA-1 was responsible for the regulation of viral gene transcription, the first step in the process by which a gene's coded information is converted first into RNA and then into protein.

Mutating the unique segment of amino acids prevented EBNA-1 from transforming resting B cells into proliferating cells.

Under normal conditions, a cellular protein binds this 25-amino acid segment of EBNA-1, allowing transcription of viral and cellular genes regulated by EBNA-1 to occur. Hammerschmidt and Sugden are now trying to identify the cellular protein.

"If we can identify this protein, it will be easier for us to develop assays to screen for small molecules that will compete with the protein in binding to EBNA-1," Sugden says. "By preventing the cellular protein from binding with the segment, EBNA-1 will not be able to carry out its function and the tumor cells it sustains will die."

The goal, which Sugden expects is achievable, is to end up with a drug that kills only EBV-positive tumor cells and doesn't harm other tissues in the body.


'"/>

Source:University of Wisconsin-Madison


Page: 1 2

Related biology news :

1. New component of the brakes on nerve regeneration found
2. Strongest proof yet found for prion hypothesis
3. A puzzle piece found in unraveling the wiring of the brain
4. New World founders small in number
5. Norovirus found to cause travelers diarrhea
6. Pair of cancer genes found to drive both cell migration and division
7. Alien woodwasp, threat to US pine trees, found in N.Y.
8. Achilles heel of the herpes virus possibly found
9. Purdue scientists may have found key to halting spinal cord damage
10. Unexpected lock and key mechanism found for the assembly of tumor blood vessels
11. New protein vital for immune response is found in surprise location
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Clue found Epstein Barr virus ability form and sustain tumors

(Date:1/22/2015)... POINT ROBERTS, Washington , January 20, 2015 ... including technology and tech stocks, releases video from the CES ... and security consultant Apollo Robbins . Apollo ... the Wocket™ biometric smart wallet, a product of NXT-ID, Inc. ...
(Date:1/22/2015)... EyeLock, Inc. , a market leader of iris-based identity authentication ... to the new role of Senior Vice President of Mobile ... mobile platforms and wearable solutions for EyeLock,s technologies. Gerber brings ... semiconductor industry to his role at EyeLock, with expertise in ...
(Date:12/22/2014)... Dec. 22, 2014 Research and Markets ... the "The Global Watermarking and Fingerprinting Markets" ... http://photos.prnewswire.com/prnh/20130307/600769 This insight ... watermarking and fingerprinting markets. Watermarking aims to control ...
Breaking Biology News(10 mins):Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 3EyeLock Names Steve Gerber as Senior Vice President of Mobile and Wearables 2The Global Watermarking and Fingerprinting Markets 2
... National Human Genome Center at Shanghai (South Center, hereafter) ... District in Shanghai. To commemorate this important event, ,which ... we specially organize a series of mini-reviews for ,this ... the attention of the Chinese life science research workers ...
... world,s premier science and technology news magazines, released its list ... projects involving physicists from Louisiana Tech University in its Top ... over 5,000 scientists and engineers from 26 nations, ranked #2 ... Markus Wobisch led a team from Louisiana Tech that is ...
... MEETING HIGHLIGHTS BREAKTHROUGH RESEARCH IN UNDERSTANDING GENETIC AND ... Although racial and ethnic differences in ... known, little is understood about the underlying causes ... seemingly intractable problem. The American Association for Cancer ...
Cached Biology News:Human genomics in China 2Human genomics in China 3Human genomics in China 4Human genomics in China 5Human genomics in China 6Human genomics in China 7Human genomics in China 8Human genomics in China 9Human genomics in China 10Human genomics in China 11Louisiana Tech physicists highlight top 10 science stories of 2008 2American Association for Cancer Research hosts Science of Health Care Disparities Meeting 2
(Date:12/24/2014)... , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, Inc. (NASDAQ: ... areas, announced the closing of an underwritten public offering of ... to an aggregate 3,500,000 shares of common stock, at an ... The warrants have a per share exercise price of $5.00, ...
(Date:12/24/2014)... “Preparative & Process Chromatography Market by Instrument (Liquid ... Valves, Guages, Seals), Accessories, Services, End User (Biotechnology, ... provides a detailed overview of the major drivers, ... impacting the preparative and process chromatography market along ...
(Date:12/24/2014)... SoundConnect’s 2015 next generation ... communication technology, provide continued education and inform users ... demonstrates online communication features and benefits; empowering users ... innovative and powerful tools. , According to SoundConnect’s ...
(Date:12/24/2014)... Dallas, Texas (PRWEB) December 23, 2014 ... mercaptan such as its definition, classification, application and ... manufacturing process, and product cost structure. Production is ... also covers upstream raw materials, equipment, downstream client ...
Breaking Biology Technology:PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2
... Pulmo BioTech Inc. (OTC Bulletin Board: PLMO; Frankfort ... receive at least $3.3 million pursuant to the ... letter of intent with Biotechnology Consulting Poland Sp. ... Product Candidate PulmoBind(TM) development work, clinical trials and ...
... produced liver cells from adult skin cells using the induced ... the University of Edinburgh,s MRC Centre for Regenerative Medicine, paves ... that can be used for in vitro hepatic disease models. ... cell type used in predictive drug toxicology. These cells are ...
... The scientists and engineers who introduced the world ... the next level of friendly competition designed to ... operations of useful robots whose dimensions are measured ... National Institute of Standards and Technology (NIST), in ...
Cached Biology Technology:Pulmo BioTech Inc. Announces Cash Details of its Previously Announced Letter of Intent Intended to Bring its Pulmonary Vascular Diagnostic Product Candidate PulmoBind(TM) to the European Market 2Pulmo BioTech Inc. Announces Cash Details of its Previously Announced Letter of Intent Intended to Bring its Pulmonary Vascular Diagnostic Product Candidate PulmoBind(TM) to the European Market 3Pulmo BioTech Inc. Announces Cash Details of its Previously Announced Letter of Intent Intended to Bring its Pulmonary Vascular Diagnostic Product Candidate PulmoBind(TM) to the European Market 4Scientists develop novel method to generate functional hepatocytes for drug testing 2Is your microrobot up for the (NIST) challenge? 2
Imject Freund's Incomplete Adjuvant (FIA)...
... XL extends the MSn performance of the ... tools to generate extensive structural information for ... , Multiple dissociation techniques (PQD, ETD, ... unpredicted metabolites , Fast polarity switching for ...
... effective - Utilizes hands-off homogenization through a vortex ... grinding - Extract DNA without hand grinding; eliminating ... , Robust tubes - Includes tough ... tube breakage , Flexible format - ...
... The LXQ linear ion trap mass ... paced analytical laboratory., The LXQ linear ion ... discovery and proteomic applications, delivering the fast ... Thermo linear ion trap at an attractive ...
Biology Products: