Navigation Links
Cloning techniques produce FDA-approved antibiotic

The successful synthesis of an antibiotic in a non-native host has provided a team of researchers at the University of Illinois at Urbana-Champaign with the potential for developing new treatments for bacterial infections.

The rapid rise of antibiotic resistance poses a serious threat to human health, and demands new treatments effective against resistant pathogens. Fosfomycin is a natural antibiotic approved by the Food and Drug Administration for the treatment of various bacterial infections, and has proven effective for the treatment of infections that have become resistant to the antibiotics penicillin and vancomycin.

Fosfomycin is a member of a class of compounds called phosphonic acids because they contain a carbon-phosphorous bond. Fosfomycin functions by inactivating an essential enzyme involved in the formation of the bacterial cell wall.

"Phosphonic acids are underexploited bioactive compounds with great potential for treating human disease," said Huimin Zhao, a U. of I. professor of chemical and biomolecular engineering. "We hope to understand the complete pathway for how fosfomycin is made."

In a paper to appear in the Nov. 27 journal Chemistry and Biology, Zhao and U. of I. chemistry professor Wilfred A. van der Donk report the first successful synthesis of fosfomycin in a non-native host.

Fosfomycin is produced by various species of bacteria, but generally in low yields. Using a cloning method developed by Illinois microbiologist William W. Metcalf, the researchers were able to clone the essential genes for fosfomycin synthesis and then produce it in a non-native host, potentially in much larger quantities.

After isolating the genetic information from fosfomycin's native host, Streptomyces fradiae, certain genes were inactivated, and the ability of a non-native host Streptomyces lividians to produce fosfomycin was assessed.

With the help of graduate students Ryan Woodyer and Zengyi Shao, Zhao
'"/>

Source:University of Illinois at Urbana-Champaign


Page: 1 2

Related biology news :

1. Cloning the smell of the seaside
2. Newer imaging techniques may lead to over-treatment
3. Rice bioengineers pioneer techniques for knee repair
4. Evolutionary biology research techniques predict cancer
5. U of MN uses robotic surgery techniques in cardiac cell therapy research
6. Imaging techniques permit scientists to follow a day -- or four -- in the life of a cell
7. Inexpensive, mass-produced genes core of synthetic biology advances at UH
8. Researchers devise way to mass-produce embryonic stem cells
9. Stem cells from brain transformed to produce insulin at Stanford
10. Anammox bacteria produce nitrogen gas in oceans snackbar
11. Proteomics brings researchers closer to understanding microbes that produce acid mine drainage
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cloning techniques produce FDA approved antibiotic

(Date:8/19/2014)... . Taking ... activity in children,Today the Canadian Society of Exercise Physiology ... activity and published their position and recommendations in the ... APNM ). This position stand provides an important ... physical activity for children and suggests both practical guidelines ...
(Date:8/19/2014)... Although body motion sensors already exist in different forms, ... complexity and cost of production. Now researchers from the ... the first time treated common elastic bands with graphene, ... for medical use and can be made cheaply. ... By fusing this material with graphene - which imparts ...
(Date:8/19/2014)... that protect their young have bigger brains than counterparts ... of British Columbia study. , Stickleback fish are well ... the male of the species, rather than the female, ... than females and researchers wanted to find out if ... as caregivers. , In the study, published recently ...
Breaking Biology News(10 mins):Taking a stand: Balancing the BENEFITS and RISKS of physical activity in children 2Taking a stand: Balancing the BENEFITS and RISKS of physical activity in children 3
... of Veterinary Bacteriology, University of Bern, Switzerland, has ... (ASM) to receive a 2011 ICAAC Young Investigator ... and molecular biology to investigate the impact of ... caused by Gram-negative bacteria. Sponsored by the ASM, ...
... New research by University of New Hampshire exercise ... effective tool for gauging exercise intensity, but that it ... other more objective tests. In a study published recently ... of kinesiology Timothy Quinn and his former graduate student ...
... CORONA, Calif., Sept. 13, 2011 AVT, Inc., ... ), continues to revolutionize the vending and automated ... provides prescription medicine refills directly to consumers, 24-hours ... or store employee. This breakthrough system ...
Cached Biology News:The American Society for Microbiology honors Andrea Endimiani 2The American Society for Microbiology honors Andrea Endimiani 3New UNH data tests the exercise 'talk test' 2
(Date:8/18/2014)... NYElectronic devices with unprecedented efficiency and data ... that use built-in electric polarizations to read ... inside most popular data-driven technology. But ferroelectrics ... blocks, including a curious habit of "forgetting" ... the U.S. Department of Energy,s Brookhaven National ...
(Date:8/18/2014)... 18, 2014 Dyadic International, Inc. ("Dyadic") ... and proprietary technologies are used to develop, manufacture ... bioenergy, bio-based chemical, biopharmaceutical and industrial enzyme industries, ... Statement on Form 10 with the U.S. Securities ... - http://photos.prnewswire.com/prnh/20110621/CL06708LOGO The ...
(Date:8/16/2014)... physicists have found a way to make atomic-force microscope ... forces as small as the weight of an individual ... Australian National University (ANU), hinges on using laser beams ... Celsius. , "The level of sensitivity achieved after cooling ... of a large virus that is 100 billion times ...
(Date:8/15/2014)...  Two 5-foot-5 superbug-slaying machines were deployed from ... to JFK Hospital and ELWA Hospital in ... , where they will aid in the fight against ... - http://photos.prnewswire.com/prnh/20140814/136426 The devices, ... environments where Ebola patients are being treated. TRU-D is ...
Breaking Biology Technology:Promising ferroelectric materials suffer from unexpected electric polarizations 2Promising ferroelectric materials suffer from unexpected electric polarizations 3Promising ferroelectric materials suffer from unexpected electric polarizations 4Dyadic International Files Form 10 Registration Statement 2Dyadic International Files Form 10 Registration Statement 3Dyadic International Files Form 10 Registration Statement 4Laser makes microscopes way cooler 2Germ-Killing Robots Deployed to the Republic of Liberia To Aid in Battle Against Ebola Virus 2Germ-Killing Robots Deployed to the Republic of Liberia To Aid in Battle Against Ebola Virus 3
... Columbus Children's Hospital announced on Tuesday that ... Ltd. to purchase the information system CardioIMS. The system ... Center , which addresses the needs of children and ... based on an in-depth study of the Center's administrative ...
... has announced that the southwestern laboratory network TriCore ... Virus genotyping reagents. , ,The reagents are part of tests ... virus, a blood-transmitted disease estimated to be chronic in 4 ... do not know it, according to Third Wave's company statement. ...
... Wingra Technologies announced on Thursday the release ... product, helps move mail, personal address books, calendars and ... Exchange format. , ,The software can handle multiple users' ... , ,"We've learned first-hand how complex and tedious a ...
Cached Biology Technology:Children's Hospital chooses Camtronics for cardiology IT system 2
... Sequencing Quality 96 Well ... BAC template preparation from 1.5ml ... suitable for automated fluorescent sequencing ... DNA; Utilizes ProPrep strategy which ...
...
TLN2 Antibody...
Olig2 Immunogen: Synthetic peptide from rat. Available Date: 9-19-2006...
Biology Products: