Navigation Links
Cloned stem cells prove identical to fertilized stem cells

. In other words, the egg needs to erase all tissue-specific memories from the skin cell and revert it into a genomic blank slate.

But this entire process is almost never perfect, and nearly all cells in a cloned blastocyst retain some memory of their original source. As a result, the developing fetus inevitably has some degree of genetic abnormality. Most clones, in fact, die in utero or at birth. The few clones that make it into adulthood are often plagued by bizarre health complications. This is one reason why scientists generally believe that attempting to clone a human being is morally reprehensible.

But are the cloned embryo's stem cells beleaguered by the same defects?

Studies have demonstrated that a small number of stem cells in the blastocyst appear to be spared this faulty reprogramming. When stem cells from a cloned blastocyst are removed and placed into a dish, most die. A few, however, survive and give rise to an embryonic stem cell line, and these appear to be thoroughly reprogrammed.

Researchers have tried to test the integrity of these surviving stem cells by transplanting them into fertilized blastocysts and then observing the overall health of the resulting animal. Although these animals generated entirely from cloned stem cells appear to be fine, many scientists don't accept this result as definitive.

Tobias Brambrink, a postdoctoral researcher in the Jaenisch lab, tried a different approach, comparing gene expression in cloned and fertilization-derived stem cells. With a series of microarray chips, Brambrink measured which genes were active and which were silent in both kinds of cells. To ensure the accuracy of his results, he compared five lines of cloned stem cells with five fertilization-derived stem cell lines.

"The results are very clear," says Brambrink. "If a gene is active in fertilized stem cells, it's also active in cloned stem cells, and at the same level of activity. The same goes
'"/>

Source:Whitehead Institute for Biomedical Research


Page: 1 2 3

Related biology news :

1. Cloned mice created from fully differentiated cells, a milestone in cloning research
2. Wisconsin scientists grow critical nerve cells
3. Spleen may be source of versatile stem cells
4. Researchers discover way to make cells in the eye sensitive to light
5. Priming embryonic stem cells to fulfill their promise
6. Lack of enzyme turns fat cells into fat burners
7. Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
8. Elusive HIV shape change revealed; Key clue to how virus infects cells
9. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
10. Enzyme allows B cells to resist death, leading to leukemia
11. Scientists rid stem cell culture of key animal cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cloned stem cells prove identical fertilized stem cells

(Date:7/23/2014)... that has the entire country in its grip is affecting ... be responsible for the proliferation of a heat-loving amoeba commonly ... hot springs, which the drought has made warmer than usual ... an infection caused by this parasite after swimming in several ... of an individual and travels to the brain. Nose plugs ...
(Date:7/23/2014)... The planet,s soil releases about 60 billion tons of ... more than that released by burning fossil fuels. This ... release of carbon is balanced by carbon coming into ... matter, as well as by the underground activities of ... that rising temperatures increase the rate of soil respiration. ...
(Date:7/23/2014)... Non-biting blow fly Chrysomya megacephala is commonly ... investigations to determine the time of death, referred to ... derived form of C. megacephala from Tamil ... morphological features and molecular characterization through generation of DNA ... in the open access Biodiversity Data Journal . ...
Breaking Biology News(10 mins):Diseases of another kind 2Climate change and the soil 2Dead body feeding larvae useful in forensic investigations 2
... mushroom (Agaricus bisporus) has as much, and in some cases, ... button mushroom is the foremost cultivated edible mushroom in the ... is often thought of as a poor relation to its ... nutritionally. But according to new research in SCIs Journal ...
... Fan Meng of China, a visionary leader who ... in Chinas rapidly industrializing Guangdong Province, has been awarded ... use the Fellowship to expand and improve the regions ... from the serious threats of industrial pollution and unsustainable ...
... to distinguish between the majority of plant species on Earth ... the Proceedings of the National Academy of Sciences journal today ... used to identify plants using a small sample, could lead ... in species-rich areas like rainforests. It could also lead to ...
Cached Biology News:2008 Pew Fellowship in Marine Conservation awarded to Fan Meng; first Chinese fellow 22008 Pew Fellowship in Marine Conservation awarded to Fan Meng; first Chinese fellow 3DNA 'barcode' identified for plants 2DNA 'barcode' identified for plants 3
(Date:7/23/2014)... year, Formedix celebrated its partnership with ... management solutions for clinical trials. The company launched its ... capture (EDC) and clinical data management. Formedix, a renowned ... TrialMaster to its Transform for EDC product line. This ... is being released this week, in response to market ...
(Date:7/23/2014)... Iowa (PRWEB) July 23, 2014 DuPont ... the business as vice president of Agricultural Biotechnology (ABT), ... Biotechnology where he served most recently as president, chief ... biotechnology and business leadership in the seed and crop ... said Paul E. Schickler , president of DuPont ...
(Date:7/23/2014)... July 23, 2014  Sofinnova Ventures, a ... the closing of Sofinnova Venture Partners IX, L.P. at ... of the initial fund target of $425 million. ... biotechnology companies. Consistent with recent funds, SVP IX will ... clinical programs, along with select investments in earlier stage ...
(Date:7/23/2014)... 23, 2014 Adult stem cells ... are biological, but not magical. However, many ... treat them as if they were magical. , ... studies that constitute “stem cell tourism,” are evaluating ... to developing new regenerative medicine therapies. In reality, ...
Breaking Biology Technology:Formedix and OmniComm Systems® Partnership Strengthened with the Release of Enhanced TrialMaster® Integration for EDC Build 2Formedix and OmniComm Systems® Partnership Strengthened with the Release of Enhanced TrialMaster® Integration for EDC Build 3DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 2DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 3Sofinnova Raises $500 Million Biotech Venture Fund 2The Adult Stem Cell Technology Center, LLC Continues to Develop Technologies for Homologous Adult Stem Cell Therapies and Drug Development 2The Adult Stem Cell Technology Center, LLC Continues to Develop Technologies for Homologous Adult Stem Cell Therapies and Drug Development 3The Adult Stem Cell Technology Center, LLC Continues to Develop Technologies for Homologous Adult Stem Cell Therapies and Drug Development 4The Adult Stem Cell Technology Center, LLC Continues to Develop Technologies for Homologous Adult Stem Cell Therapies and Drug Development 5
... VALENCIA, Calif., Nov. 20 MannKind,Corporation (Nasdaq: MNKD ... and cancer, announced today that it,will present at the ... AM ET at the Pierre Hotel in New York, ... the live web cast of the,presentation in the Investor ...
... Nov. 20 Sports and,nutritional product manufacturer, Natural ... announced today that it has,launched an international marketing ... Relief Cream. Made from a combination of,botanical and ... the internet and television. Natural Nutrition,s BLUE ...
... Nov. 20 /Xinhua-PRNewswire-FirstCall/ -- 3SBio Inc.,(Nasdaq: SSRX ... developing, manufacturing and marketing biopharmaceutical,products, announces today that ... the 19th Annual Piper Jaffray Health Care Conference ... November 27, 2007 at 4:30 P.M. EST. ...
Cached Biology Technology:Natural Nutrition Launches International Marketing Campaign for New All Natural Analgesic: BLUE LIGHTNING(TM) Fast Pain Relief 2
NEWBORN CALF SERUM AND PLASMA...
Synaptic Vesicle I Sampler Kit 10g each...
Hybridization chamblers suitable for use with all ChIP-GLAS microarrays....
Rabbit polyclonal to BCA1 ( Abpromise for all tested applications). Antigen: Generated using E.coli expressed mouse BCA1. Entrez GeneID: 10563 SWISS Protein ID: O43927...
Biology Products: