Navigation Links
Cloned stem cells prove identical to fertilized stem cells

Scientists generally agree that all cloned animals are biologically flawed. But they don't agree about what that means for stem cells derived from cloned embryos, the basis for therapeutic cloning.

Also known as somatic cell nuclear transfer, therapeutic cloning is a promising approach to create individually customized cellular therapies for treating certain disorders. Demonstrated in mice but not in humans, it begins with stem cells derived from a cloned embryo. But if cloned embryos can't produce normal organisms, how can they produce normal stem cells?

Analyzing the complete gene-expression profiles of both cloned and fertilization-derived stem cells in mice, scientists at Whitehead Institute for Biomedical Research now have concluded that the two are, in fact, indistinguishable.

"This paper demonstrates clearly that it doesn't matter if a stem cell has been derived from a cloned embryo or from a fertilized embryo," says Whitehead Member Rudolf Jaenisch, senior author on the paper that will appear in the online the week of January 16 in the Proceedings of the National Academy of Sciences. "Both can be equally good for therapy."

To create a clone, a scientist removes the nucleus from a donor cell, then places it into an egg from which the nucleus has been removed. The researcher then tricks the egg into thinking it's been fertilized. The egg develops into a blastocyst, an early stage embryo consisting of no more than 100 or so cells. The scientist can then either remove the stem cells from this blastocyst, or place it into a uterus where it has the potential to develop into a fetus.

Here's where things get complicated. The original donated nucleus may have come from, say, a skin cell. For a viable fetus to develop, the egg needs to reprogram the genome of the skin cell, shutting off genes specific for skin tissue and turning on genes needed for embryonic development, genes that are normally dormant in tissue-specific cells
'"/>

Source:Whitehead Institute for Biomedical Research


Page: 1 2 3

Related biology news :

1. Cloned mice created from fully differentiated cells, a milestone in cloning research
2. Wisconsin scientists grow critical nerve cells
3. Spleen may be source of versatile stem cells
4. Researchers discover way to make cells in the eye sensitive to light
5. Priming embryonic stem cells to fulfill their promise
6. Lack of enzyme turns fat cells into fat burners
7. Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
8. Elusive HIV shape change revealed; Key clue to how virus infects cells
9. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
10. Enzyme allows B cells to resist death, leading to leukemia
11. Scientists rid stem cell culture of key animal cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cloned stem cells prove identical fertilized stem cells

(Date:7/11/2014)... July 11, 2014 Researchers have pioneered ... images. The new technology, called Virtual Finger, allows ... structures like neurons and synapses using the flat ... technology makes 3D imaging studies orders of magnitude ... an unprecedented level across many areas of experimental ...
(Date:7/11/2014)... There is evidence that under the normal ... and development, maintain neuronal environment, and exhibit ... and neurodegenerative disease. Previous studies have found ... cells after chemical induction have reduced viability, ... application. Prof. Xiaodong Yuan, Kailuan General Hospital, ...
(Date:7/11/2014)... the brains of all vertebrates, information is transmitted ... or chemical signal to be passed from one ... the most abundant type of synapse, can be ... for learning, memory, perception and cognition, and the ... brain function. For instance, every time we ...
Breaking Biology News(10 mins):Virtual finger enables scientists to navigate and analyze complex 3D images 2Blame it on the astrocytes 2
... researchers and engineers try to shrink diagnostics to fit in ... and mix small samples of liquid. University of Washington researchers ... drops along certain paths to conduct medical or environmental tests., ... want, and in any kind of layout that we want," ...
... Germany, 9 May 2012 Fifty-five life scientists from ... EMBO for their excellence in research. Forty-eight of the ... scientists from Argentina, Australia, South Korea and the United ... now comprises almost 1,550 life scientists in the international ...
... team of researchers, working on behalf of the European ... upper level for vitamin A consumption for puppies. The ... of science-based recommendations for vitamin A levels for puppies ... This research was conducted by scientists from ...
Cached Biology News:Portable diagnostics designed to be shaken, not stirred 2Collaborative research team identifies safe upper level for vitamin A consumption for puppies 2
(Date:7/10/2014)... upside down forever. Nanophysics makes sure of that. Mechanics researchers ... published in Physical Review E . Knowledge that can ... seem to be able to sit still forever, and walk ... We will soon be able to buy smart new fasteners ... the fact is, sooner or later the grip is lost, ...
(Date:7/10/2014)... researchers at the University of Illinois at Urbana-Champaign ... the interplay of spin and heat at the ... spintronic devices for data storage and information processing. ... as spin-angular momentum. In a typical charge current, ... spin current," explained David Cahill, a professor of ...
(Date:1/15/2014)... akin to assembling a club sandwich at the ... researchers have succeeded in crafting a uniform, multi-walled ... foam commonly used in upholstered furniture and other ... polyurethane foam was reduced 35 percent compared with ...
(Date:1/15/2014)... Automotive, a group of car dealerships headquartered in ... Center and offering free oil change coupons for participation in ... 18 at the Bill Jacobs Cadillac and Chevrolet location from ... )  The Bill Jacobs Auto annual blood ...
Breaking Biology Technology:Even geckos can lose their grip 2University of Illinois study advances limits for ultrafast nano-devices 2Layered security: Carbon nanotubes promise improved flame-resistant coating 2Join the Bill Jacobs Auto blood drive and receive a free oil change 2
... been awarded a $1 million grant from the W.M. ... developing a new microscope that uses a light-guiding "metamedium" ... with significantly improved clarity. The nanoscale coaxial optical ... microscopes known as "superlenses," which function far differently than ...
... MON ) will hold a webcast next Wednesday ... president – global strategy, at the Goldman Sachs Agricultural Biotech ... 9.   Preete will discuss the company,s business ... to the business. Slides and a simultaneous ...
... by a Barrow Neurological Institute scientist on the thermoregulatory effects ... pain is the cover story in the Feb. 2 issue ... conducted by an international team led by Andrej Romanovsky, MD, ... which is a part of St. Joseph,s Hospital and Medical ...
Cached Biology Technology:Boston College receives W.M. Keck Foundation funding for nanoscale optical microscope 2Barrow TRPV1 research highlighted in Journal of Neuroscience 2
Because it is manufactured at our ISO 9001–certified facilities in Eugene, Oregon, we can guarantee that FluoroPure grade propidium iodide is greater than or equal to 98% pure by HPLC....
MOUSE ANTI RAT RT1Bu Immunogen: Rat thymocyte membrane glycoproteins...
... (100+kb), fosmid (40kb), and large plasmid insert ... othe BAC vector. On command 20-50 fold ... recombinant DNA purification. Available with blue-white screening ... for the highest insert stability. Kits include ...
SHEEP ANTI HUMAN ESTRONE...
Biology Products: