Navigation Links
Cloned stem cells prove identical to fertilized stem cells

Scientists generally agree that all cloned animals are biologically flawed. But they don't agree about what that means for stem cells derived from cloned embryos, the basis for therapeutic cloning.

Also known as somatic cell nuclear transfer, therapeutic cloning is a promising approach to create individually customized cellular therapies for treating certain disorders. Demonstrated in mice but not in humans, it begins with stem cells derived from a cloned embryo. But if cloned embryos can't produce normal organisms, how can they produce normal stem cells?

Analyzing the complete gene-expression profiles of both cloned and fertilization-derived stem cells in mice, scientists at Whitehead Institute for Biomedical Research now have concluded that the two are, in fact, indistinguishable.

"This paper demonstrates clearly that it doesn't matter if a stem cell has been derived from a cloned embryo or from a fertilized embryo," says Whitehead Member Rudolf Jaenisch, senior author on the paper that will appear in the online the week of January 16 in the Proceedings of the National Academy of Sciences. "Both can be equally good for therapy."

To create a clone, a scientist removes the nucleus from a donor cell, then places it into an egg from which the nucleus has been removed. The researcher then tricks the egg into thinking it's been fertilized. The egg develops into a blastocyst, an early stage embryo consisting of no more than 100 or so cells. The scientist can then either remove the stem cells from this blastocyst, or place it into a uterus where it has the potential to develop into a fetus.

Here's where things get complicated. The original donated nucleus may have come from, say, a skin cell. For a viable fetus to develop, the egg needs to reprogram the genome of the skin cell, shutting off genes specific for skin tissue and turning on genes needed for embryonic development, genes that are normally dormant in tissue-specific cells
'"/>

Source:Whitehead Institute for Biomedical Research


Page: 1 2 3

Related biology news :

1. Cloned mice created from fully differentiated cells, a milestone in cloning research
2. Wisconsin scientists grow critical nerve cells
3. Spleen may be source of versatile stem cells
4. Researchers discover way to make cells in the eye sensitive to light
5. Priming embryonic stem cells to fulfill their promise
6. Lack of enzyme turns fat cells into fat burners
7. Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
8. Elusive HIV shape change revealed; Key clue to how virus infects cells
9. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
10. Enzyme allows B cells to resist death, leading to leukemia
11. Scientists rid stem cell culture of key animal cells
Post Your Comments:
(Date:9/4/2008)...rful supercomputers capable of analyzing decades o... milestone capable of bringing comprehensive chang... worldwide. Researchers at the University of Miami...ence, collaborating with NCAR (National Center for...d-Atmospheric Studies) and the University of Calif...
(Date:9/4/2008)...008) A variety of organismsfrom bacteria and fun...here the timing and duration of fundamental biolog... to adapt and survive, even under fluctuating envi...t advances have been made to understand the molecu...into modifications in cellular physiology and orga...
(Date:9/4/2008)... . , Cystic kidney disease, renal fibrosis, or r...y organs are characterized by overproduction or o... in the renal cells. An international research tea... Heidelberg University Hospitals has now developed...tions. , The researchers introduced a genetic s...
(Date:9/4/2008)...Cancer Symposium features the latest cutting-edge ... breast cancer research. This year,s meeting focus... well as strides being made in diagnosing and prev...t advantage of the symposium,s scientific abstract...t www.sabcs.org to view the new press policies d...
Breaking Biology News(10 mins):Petascale climate modeling heats up at University of Miami 2Petascale climate modeling heats up at University of Miami 3Interdisciplinary volume on biological rhythms serves as both primer and in-depth resource 2Gaining a better understanding of kidney diseases 2Weight Watchers Announces Fourth Quarter and Full Year 2007 Earnings Conference Call 10066 1Weight Watchers Announces Fourth Quarter and Full Year 2007 Earnings Conference Call 10066 2Putting on Pedometer Helps Walkers Shed Pounds 10063 1Putting on Pedometer Helps Walkers Shed Pounds 10063 2Putting on Pedometer Helps Walkers Shed Pounds 10063 3Renaissance Health Publishing LLC Warns the Public that ConsumerLab com is Not Independent and Labels the CL Seal of Approval a Worthless Paid For A 10060 1Renaissance Health Publishing LLC Warns the Public that ConsumerLab com is Not Independent and Labels the CL Seal of Approval a Worthless Paid For A 10060 2Renaissance Health Publishing LLC Warns the Public that ConsumerLab com is Not Independent and Labels the CL Seal of Approval a Worthless Paid For A 10060 3Renaissance Health Publishing LLC Warns the Public that ConsumerLab com is Not Independent and Labels the CL Seal of Approval a Worthless Paid For A 10060 4Renaissance Health Publishing LLC Warns the Public that ConsumerLab com is Not Independent and Labels the CL Seal of Approval a Worthless Paid For A 10060 5Deafness and seizures result when mysterious protein deleted in mice 10057 1Deafness and seizures result when mysterious protein deleted in mice 10057 2Deafness and seizures result when mysterious protein deleted in mice 10057 3
... Weizmann Institute findings might advance search ...istance messengers star in many heroic tales, perh... who carried the news about the victory of the Gre...athon. A team of researchers at the Weizmann Insti...essengers perform a crucial role in the ability of...
... The hydrothermal vents were miles from where anyo...was an unheard of 18 stories tall. And all were cr...omposition than vent systems studied since the 197...w they were looking at something never seen before...December 2000 during a National Science Foundation...
... The human brain is like a general in a bunker. Fl...s no direct window to the outside world, so the on...rder the body into action is to rely on informatio...h a sophisticated system of sensory neurons that c..., and mouth. , In recent years, biologists and ne...
... Traditionally if scientists wanted to look at som...scope but now researchers have managed to shrink t... cell. An interdisciplinary research team, funded ...ch Council (BBSRC) and the Engineering and Physica... optical biochips no larger than a single cell tha...
Other Biology News:Molecular messengers perform a crucial role in the ability of injured nerve cells to heal themselves 2Hydrogen and methane provide raw energy for life at 'Lost City' 2Hydrogen and methane provide raw energy for life at 'Lost City' 3Hydrogen and methane provide raw energy for life at 'Lost City' 4Molecular thermometers on skin cells detect heat and camphor 2Molecular thermometers on skin cells detect heat and camphor 3Molecular thermometers on skin cells detect heat and camphor 4Microscopes at microscopic size 2
(Date:9/5/2008)... WASHINGTON The Food & Drug Administration (FDA) ...Report. This report acknowledged that nanoscale ma...types regulated by the agency and that those mater...at properties relevant to product safety and effec...scale. , Anticipating the potential for rapid c...
(Date:9/5/2008)..., For most of us, gold is only valuable if we pos...r is better" rule isn,t the case for those interes...talyze a wide variety of chemical reactions, inclu...O) into harmless carbon dioxide at room temperatur...ally improve the effectiveness of catalytic conver...
(Date:9/5/2008)... SAN DIEGO, Sept. 5 /- Ge...day that the Company will present at the Morgan,St...esday, September 9,2008 at approximately 2:45 p.m...e webcast live and may be accessed through a link ... http://www.gen-probe.com . The webcast,will be a...
(Date:9/5/2008)... EAST LONGMEADOW, Mass., Sept. 5 /-...symptoms associated with an enlarged prostate,now ...t to cure the,problem. biolitec, Inc. is pleased t...egon is now offering its breakthrough LIFE(TM) (La...benign prostate hyperplasia (BPH),that quickly and...
Breaking Biology Technology:Nanotechnology and the FDA: size matters 2NIST and partners identify tiny gold clusters as top-notch catalysts 2Gen-Probe to Webcast Presentation at the Morgan Stanley Global Healthcare Unplugged Conference 2Revolutionary New In-Office EVOLVE(R) Laser Prostate Treatment Available Throughout Western Oregon 2
...d a commitment of more than a half million dollars...he ACC Foundation to fund and support a new ACC Fe...he three-year, $530,000 contribution will be to of...ardiologists who have recently completed their tra...young researchers and the future of medical profes...
...based division of Bruker BioSciences Corporation, ...in Chicago Thursday. Highlighted products include ...structures, a new solution for the S2 RANGER energ...tions. , ,Bruker AXSs Crystal Farm imaging system ...allization. By integrating incubation at predeterm...
...rofessors work to impart the theory and the practi...r many professions, skill with information technol... truer than in the School of Library and Informati...tin Eschenfelder and her colleagues at SLIS train ...etically, the principles learned extend to any set...
...gnizing nPoint, Inc. for major contributions to ...n. nPoint, a Madison-based provider of motion devi...ufacturing, is one of three winners of the annual ...ukesha. , ,The MIT Club of Wisconsin consists of a... who live in the state. , ,The club gives three aw...
Other Biology Technology:Bruker AXS launches new products at PITTCON 2004 2Closing the IT gap 2
Anti-human VEGFR-1/Flt-1, clone Flt-1/EWI, Monoclonal Antibody
...dy Panels to its expanding line of stem cell produ... Panel (Catalog # SC008) contains the antibodies a...-1 and SSEA-4. The Human Embryonic Stem Cell Marke...ntibodies against: CD9, E-Cadherin, Nanog, Oct-3/4...
Request Info
...oice of Printing Surface (3 glass slides coated wi... layer, 1 silicon wafer coated with 1000 Angstroms...slides), PDMS Stamps (3 PDMS micropatterned stamps... x 10 mm or 200 um x 10 mm lines, 3 PDMS nano-patt...
Biology Products: