Navigation Links
Cloned mice created from fully differentiated cells, a milestone in cloning research

New research dismisses the notion that adult stem cells are necessary for successful animal cloning, proving instead that cells that have completely evolved to a specific type not only can be used for cloning purposes, but they may be a better and more efficient starting point. As proof, researchers report they created two mouse pups from a type of blood cell that itself is incapable of dividing to produce a second generation of its own kind.

This is the first demonstration that an animal can be derived directly from a fully differentiated cell, report lead researchers Xiangzhong (Jerry) Yang, Ph.D., of the University of Connecticut, and Tao Cheng, M.D., of the University of Pittsburgh, in the journal Nature Genetics. Moreover, they say results of their studies provide compelling evidence that Dolly the sheep and other mammals cloned by somatic cell nuclear transfer were most likely derived from fully differentiated cells, not adult stem cells, as most have argued in the nine years since Dolly was first created. Because stem cells have the ability to self-renew and differentiate into any specialized cell type, they have been heralded for their promise for treating a variety of diseases and conditions. Yet, even for cloning of an embryo to the blastocyst stage, from which embryonic stem cells can be generated, adult stem cells have yielded disappointing results, with success rates in the range of 1 to 5 percent.

Somatic cell nuclear transfer (SCNT), the scientific term for cloning, involves creating an embryo by using a nucleus that's been removed from a somatic cell ?any cell other than a reproductive cell ?and transferring it into an unfertilized egg that has had its chromosomes removed. Because the resulting new embryo contains the entire genome of the donor somatic cell it is an identical copy. This cloned embryo is then implanted into a surrogate mother, and, if the process is successful, is carried to term.

In their studies, the resea
'"/>

Source:University of Pittsburgh Medical Center


Page: 1 2 3 4

Related biology news :

1. Cloned stem cells prove identical to fertilized stem cells
2. Molecular research suggest shift needed in how some drugs are created
3. All placebos not created alike
4. Pinball protons created by ultraviolet rays and other causes can lead to DNA damage
5. Polynesia explorers created worldwide web of scientific knowledge
6. Sperm created in the laboratory from embryonic stem cells produce viable progeny
7. Researcher examines polymers created with poultry feathers
8. Early-stage sperm cells created from human bone marrow
9. New, automated tool successfully classifies and relates proteins in unprecedented way
10. Biomarkers isolated from saliva successfully predict oral and breast cancer
11. UN successfully tests green pesticide against locusts
Post Your Comments:
(Date:7/11/2014)... fire started near the City of Entiat on Tuesday, ... the fire quickly grew to over 1,000 acres by ... fire is under investigation by the Washington Department of ... existing local resources in developing fire control strategies and ... Washington State Department of Natural Resources, (WA DNR), Bureau ...
(Date:7/11/2014)... a new professorship in tissue engineering to promote ... Engineering and the Marine Biological Laboratory, supported by ... Eugene Bell Foundation., The Eugene Bell Professorship in ... Molecular Engineering. That endowed chair holder also will ... Bell Center for Regenerative Biology and Tissue Engineering, ...
(Date:7/11/2014)... TRAP" to capture the early signs of kidney failure, ... Journal of Clinical Investigation . Their new transgenic ... cellular and genetic information from a variety of solid ... for Medical Research in 2008, TRAP involves attaching a ... the cell type of interest. Scientists can then collect ...
Breaking Biology News(10 mins):New professorship in tissue engineering links molecular engineering, marine biology 2
... 9, 2012) In a study to be presented today ... Meeting , in Dallas, Texas, researchers will report findings that ... rupture of membranes between the 34th and 37th week of ... risk of infection or respiratory problems in the newborn. ...
... Some unusual alliances are necessary for you to ... enable better treatment of neuromuscular diseases, such as myasthenia ... brain, said Dr. Lin Mei, Director of the Institute ... University. , During development, neurons in the spinal cord ...
... in rice grains conducted by researchers at the RIKEN ... 131 rice metabolites and clarified the genetic and environmental ... natural way to bioengineer improved rice grain varieties by ... value of crops. As one of the most ...
Cached Biology News:Study indicates that induced labor may not lower risk of infection or respiratory problems in newborns 2Unusual alliances enable movement 2New study sheds light on genetics of rice metabolism 2
(Date:7/14/2014)... CA (PRWEB) July 14, 2014 ... patient registry platform, announced that three PatientCrossroads-based ... dystrophies; the Phelan-McDermid Syndrome International Registry; and ... Syndrome—have been awarded contracts by the Patient-Centered ... the creation of a new health data ...
(Date:7/11/2014)... -- , Not for release, publication or distribution ... jurisdiction where to do so would constitute a violation of ... ("Shire" or the "Company") (LSE: SHP, NASDAQ: SHPG ... has held a meeting with representatives of AbbVie. ... agreement or approval of AbbVie. A further update ...
(Date:7/11/2014)... , July 11, 2014  Researchers have ... three-dimensional images. The new technology, called Virtual Finger, ... small structures like neurons and synapses using the ... unique technology makes 3D imaging studies orders of ... at an unprecedented level across many areas of ...
(Date:7/10/2014)... (PRWEB) July 10, 2014 Understanding the ... channel-expressing cell lines, and the gap that currently exists ... that expand its industry-leading portfolio of validated ion channel ... ion channel-expressing cell lines, as ion channels control many ... control this activity creates the potential to treat a ...
Breaking Biology Technology:PatientCrossroads Fuels Development of New National Clinical Research Network 2PatientCrossroads Fuels Development of New National Clinical Research Network 3Shire plc - Statement re: Media Speculation 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 3Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3
... United,Therapeutics Corporation (Nasdaq: UTHR ) announced today ... results before market open on,Thursday, October 30, 2008., ... on Thursday,October 30, 2008, at 9:00 a.m. Eastern ... international callers dialing,1-706-679-8129. A rebroadcast of the teleconference ...
... Oct. 23 SuperGen, Inc.,(Nasdaq: SUPG ... discovery and,development of novel cancer therapies, today ... and four additional posters, at the 20th,EORTC-NCI-AACR ... in,Geneva, Switzerland. MP-470, an orally bio-available multi-targeted,tyrosine ...
... 2008) -- A study seeking possible cancer genes elucidated the ... form of lung cancer lung adenocarcinoma and could ... the Baylor College of Medicine Human Genome Sequencing Center that ... National Human Genome Research Institute. , In the report ...
Cached Biology Technology:SuperGen's MP-470 Demonstrates Clinical Tumor Regression When Combined with Standard of Care Chemotherapy 2SuperGen's MP-470 Demonstrates Clinical Tumor Regression When Combined with Standard of Care Chemotherapy 3SuperGen's MP-470 Demonstrates Clinical Tumor Regression When Combined with Standard of Care Chemotherapy 4Unraveling the genetic picture of lung cancer 2
... in an easy-to-use benchtop package. Our ... (ESI-oa-TOF) concentrates the performance of a ... fits on your bench. The microTOFLC ... FWHM and mass accuracy of better ...
... IndicationIncludes all the features of Tracker, plus software ... for a user defined period of time in ... a family of instruments all built around a ... and that can track two fields at once ...
... features of Tracker, plus software to note when ... provide a food reward.The Spatial Behavior line is ... video camera, frame grabber, and feature extraction software ... and up to 6 moving animals. Software ...
... Tracker, plus software to note when an animal ... arena, and trigger a penaltyThe Spatial Behavior line ... a video camera, frame grabber, and feature extraction ... once and up to 6 moving animals. ...
Biology Products: