Navigation Links
Clean skies=faster global warming?

When microorganisms invade the body, immune mechanisms kick in to fight them off. The infected tissues typically show depleted oxygen levels, and a protein called HIF-1 alpha regulates this. Interestingly, the cells responsible for destroying the foreign pathogens are effective in this low-oxygen environment. In a new study appearing in the July 1 print issue of The Journal of Clinical Investigation, Randall Johnson and collegues from UCSD show for the first time that induction of the HIF-1 pathway can act as a "super-antibiotic", accelerating the killing of bacteria in conditions typical of those found during bacterial infection and sepsis.

The authors show that regulation of HIF-1 is required for immune defense against bacterial infection. They also show that bacteria killing is increased under conditions of low oxygen due to HIF-1 upregulation, and that bacterial infection upregulates HIF-1. In fact, upregulation of HIF-1 enhances expression of bactericidal agents and killing of bacteria.

This reveals that a novel approach to treating bacterial infection is by increasing the killing capacity of cells of the innate immune system. In a related commentary, Kol Zarember and Harry Melach write, "By dissecting the role of HIF-1 in innate immune defenses, the study…introduces new targets for therapeutic immunomodulation."

###

TITLE: HIF-1alpha expression regulates the bactericidal capacity of phagocytes

View the PDF of this article at: https://www.the-jci.org/article.php?id=23865

ACCOMPANYING COMMENTARY:

Title: HIF-1alpha: a master regulator of innate host defenses?

View the PDF of this article at: https://www.the-jci.org/article.php?id=25740


'"/>

Source:NERC


Page: 1

Related biology news :

1. Scientists collaborate to assess health of global environment
2. Nonlinear Dynamics announces more details of its global partnership with PerkinElmer
3. DuPonts first biologically derived polymer receives global recognition
4. Virus-host interactions at sea effect global photosynthesis
5. Hopkins AIDS experts issue warning about global efforts to provide drug therapies
6. Scientists discover global pattern of big fish diversity in open oceans
7. AIDS expert says global strategy needed to combat feminization of HIV/AIDS
8. Marine bacterium suspected to play role in global carbon and nitrogen cycles
9. Errors in the measurement of global warming corrected
10. Storing carbon to combat global warming may cause other environmental problems, study suggests
11. The shape of things to come: Morphology database going global
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Clean skies global warming

(Date:3/17/2015)...  MecklerMedia Corporation (OTCQX: MECK) announced its ... ever held in New York City ... 2015 at the Javits Convention Center. ... Acorn Product Development; Axis NJ; c-Link Systems; CoroWare; ... NewBotic Corporation; Neya Systems LLC; Reliabotics; RoboKind; RocketFarm ...
(Date:3/12/2015)... -- Beta Systems today announced Fast ... (IAM) solution for a fixed price and with ... IAM package, customers benefit from the 30 years, ... implementations across different industries. The new fixed-price IAM ... necessary services and consulting. It spans the implementation ...
(Date:3/10/2015)...  Continuing its 167-year history of offering the Best, ... The Eye Scanning Password Authenticator , a device that ... websites or sensitive data. Employing the same ... the device has a small camera that scans and ... converting them into an encrypted ID that cannot be ...
Breaking Biology News(10 mins):MecklerMedia's RoboUniverse New York Announces Sponsors and Exhibitors, May 11-13, 2015 2Beta Systems Fast Forward IAM Available Now: a Standardized IAM Package at a Fixed Price 2Hammacher Schlemmer Introduces The Eye Scanning Password Authenticator 2
... Spanish . ,The oil spill from ... to the ecosystems in the Bay of Biscay. A PhD ... studied the consequences of this spill for the mussels inhabiting ... of the PhD thesis is the biologist Ms Larraitz Garmendia ...
... Norway MA Current research describes a new method ... onset of symptoms. The related report by Zangani et ... NF-κB activation reveals pathology in multiple organ systems," appears ... Journal of Pathology . Autoimmune diseases such as ...
... Germ cells, the cells which give rise to a ... rate of spontaneous point mutations than adult somatic cells, which ... organs. Despite their comparatively higher mutation rates, however, adult ... cloning process called somatic cell nuclear transfer (SCNT). This ...
Cached Biology News:The Prestige oil spill caused changes in the cell structure of mussels 2Stopping autoimmunity before it strikes 2Therapeutic cloning gets a boost with new research findings 2
(Date:3/26/2015)... SQI Diagnostics Inc. ("SQI" or the "Company") (TSX-V: SQD; ... including the appointment of auditors, its annual and special ... "Meeting") was adjourned, as previously disclosed on March 25, ... Toronto time). The date of the ... The Meeting will reconvene at the offices of the ...
(Date:3/26/2015)...  BioNano Genomics, Inc., the leader in genome mapping, ... chief commercial officer. Salyer has more than 20 years ... life sciences. At BioNano, Salyer will oversee the commercialization ... to assemble a comprehensive view of complex genomes to ... institutions located in the United States ...
(Date:3/26/2015)... Corporation (NASDAQ: NEOG ) announced today that its ... which ended Feb. 28, increased 13% to $7,454,000, when ... in the current quarter were $0.20, compared to $0.18 ... over prior year to $24,142,000, or $0.65 per share, ... same period a year ago. Revenues for ...
(Date:3/26/2015)... Houston, Texas (PRWEB) March 26, 2015 ... assist technologies, and Transonic, a supplier of precision transit-time ... board that will greatly improve the efficiency of the ... will enable LVAD patients to experience greater mobility and ... embedded with the miniature flow board, will draw 1/6th ...
Breaking Biology Technology:SQI Diagnostics Inc. Announces Adjournment of Meeting 2BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 2BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 3Neogen reports 13% increase in net income 2Neogen reports 13% increase in net income 3Neogen reports 13% increase in net income 4Neogen reports 13% increase in net income 5Neogen reports 13% increase in net income 6Neogen reports 13% increase in net income 7Neogen reports 13% increase in net income 8LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 2LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 3
... Pharmasset, Inc.,(Nasdaq: VRUS ) announced today that its ... Conference being held from September 24 - 27,2007 in ... Chief,Executive Officer, will provide an overview of the company ... To access a simultaneous webcast of the presentation via ...
... Studies Demonstrate Activity of ... Gram-Positive Bacteria, CHICAGO, Sept. 18 Astellas ... ) announced today results with the,investigational compound telavancin ... skin structure infections,(cSSSIs) from a controlled Phase 3 ...
... /PRNewswire-FirstCall/-- Biodel Inc. (Nasdaq:,BIOD) today announced additional ... 43rd Scientific Sessions of the European Association ... Phase II meal study data was disclosed ... and pharmacodynamics of,insulin VIAject(TM), insulin lispro and ...
Cached Biology Technology:Pharmasset to Present at the UBS Global Life Sciences Conference on Monday, September 24th 2Astellas and Theravance Report Additional Telavancin Data at 47th Annual ICAAC 2Astellas and Theravance Report Additional Telavancin Data at 47th Annual ICAAC 3Astellas and Theravance Report Additional Telavancin Data at 47th Annual ICAAC 4Astellas and Theravance Report Additional Telavancin Data at 47th Annual ICAAC 5Astellas and Theravance Report Additional Telavancin Data at 47th Annual ICAAC 6Biodel Inc. Announces VIAject(TM) Phase II Meal Study Data at the 2007 European Association for the Study of Diabetes Meeting 2Biodel Inc. Announces VIAject(TM) Phase II Meal Study Data at the 2007 European Association for the Study of Diabetes Meeting 3
... Spacer Leu-CMK FLISP Assay with FAM-Labeled ... nm) • Accurately measure serine protease ... permeabilization • B-Bridge's FLISP Kits utilize ... proteases (FLISPs) to measure chymotrypsin-like activity ...
Request Info...
... tool provides the firm pressure necessary ... in tubes or plates. The multifunctional ... that firmly holds thin-wall 0.5 ml ... opening or closing. A side slot ...
... microbial system, 100 to 240 V, ... of bacterial and fungal cells. This ... module for exponential decay delivery, ShockPod ... each of 0.1 and 0.2 cm ...
Biology Products: