Navigation Links
Circumcision: A proven strategy to prevent HIV

Male circumcision significantly reduces the risk of acquiring HIV in young African men, according to a study led by University of Illinois at Chicago professor of epidemiology Robert Bailey.

The study is published in the Feb. 24 issue of The Lancet.

Researchers conducted a clinical trial enrolling 2,784 HIV negative, uncircumcised men between 18 and 24 years old in Kisumu, Kenya, where an estimated 26 percent of uncircumcised men are HIV infected by age 25. The majority of the men in the study were Luo, an ethnic group that does not traditionally practice circumcision.

Half the men were randomly assigned to circumcision and half the men remained uncircumcised for two years.

Participants received free HIV testing and counseling, medical care, tests and treatment for sexually transmitted infections, condoms and behavioral risk counseling during periodic assessments throughout the study.

The clinical trial found that 47 of the 1,391 uncircumcised men contracted HIV, compared to 22 of the 1,393 circumcised men.

"Our study shows that circumcised men had 53 percent fewer HIV infections than uncircumcised men," said Bailey. "We now have very concrete evidence that a relatively simple surgical procedure can have a very large impact on HIV."

The study also measured adverse events related to surgery. According to Bailey, in 1.7 percent of the surgeries there were minor complications -- usually bleeding or a mild infection. There were no severe adverse events.

Bailey cautions that circumcised men may feel they are protected from becoming HIV infected and may be more likely to engage in risky behavior.

"Circumcision is by no means a natural condom," said Bailey. "We do know that some circumcised men become infected with HIV. But we did find that the circumcised men in our study did not increase their risk behaviors after circumcision. In fact, all men in the trial increased their condom use and reduced their number of sexual partners."

The authors conclude that circumcision will be most effective if it is integrated with other prevention and reproductive health services.

"We have wonderful new drugs to at least maintain people for many years with the virus, but meanwhile more people are getting infected at a rate of approximately 5,000 persons per day," said Bailey. "We cannot treat our way out of this epidemic. Prevention of new infections is crucial."

Simulation models estimate that millions of new HIV infections, tens of thousands of deaths, and several million dollars could be saved if male circumcision became routine in sub-Saharan Africa.

"This is really the first good news we've had in quite a long time. If we can reduce the risk of infection by such a substantial amount then we can save a lot of lives."

In December the National Institutes of Health halted Bailey's trial of male circumcision after the study's independent data safety monitoring board reviewed the preliminary results and recommended that all men enrolled in the study who remain uncircumcised be offered circumcision due to the clearly protective effect.


Source:University of Illinois at Chicago

Related biology news :

1. HIVMA opposes The Gambias unproven AIDS remedy
2. Gene silencing technique offers new strategy for treating, curing disease
3. AIDS expert says global strategy needed to combat feminization of HIV/AIDS
4. Asleep in the deep: Model helps assess ocean-injection strategy for combating greenhouse effect
5. Melanoma vaccine strategy shows promise in laboratory experiments
6. Study by Einstein researchers could lead to a novel strategy for treating obesity
7. Team discovers possible universal strategy to combat addiction
8. Researchers discover way to transport environmental arsenic to plant leaves in new clean-up strategy
9. Attacking cancers sweet tooth is effective strategy against tumors
10. New strategy rapidly identifies cancer targets
11. Researchers unveil strategy for creating actively-programmed anti-cancer molecules
Post Your Comments:

(Date:4/13/2017)... SANTA MONICA, Calif. , April 13, 2017 /PRNewswire/ ... New York will feature emerging and ... Innovation Summits. Both Innovation Summits will run alongside the ... variety of speaker sessions, panels and demonstrations focused on ... east coast,s largest advanced design and manufacturing event will ...
(Date:4/11/2017)... 2017 NXT-ID, Inc. (NASDAQ:   NXTD ... the appointment of independent Directors Mr. Robin D. Richards ... of Directors, furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief ... to their guidance and benefiting from their considerable expertise as ...
(Date:4/4/2017)... , April 4, 2017   EyeLock LLC ... announced that the United States Patent and Trademark Office ... broadly covers the linking of an iris image with ... transaction) and represents the company,s 45 th issued ... patent is very timely given the multi-modal biometric capabilities ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... 10, 2017 SomaGenics announced the receipt of ... develop RealSeq®-SC (Single Cell), expected to be the first ... (including microRNAs) from single cells using NGS methods. The ... to accelerate development of approaches to analyze the heterogeneity ... "New techniques for measuring levels of mRNAs in individual ...
(Date:10/9/2017)... ... October 09, 2017 , ... The award-winning American Farmer television ... quarter 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. , With global ... the challenge of how to continue to feed a growing nation. At the same ...
(Date:10/7/2017)... Arizona (PRWEB) , ... October ... ... 15 years’ experience providing advanced instruments and applications consulting for microscopy and ... in-house expertise in application consulting, Nanoscience Analytical offers a broad range of ...
(Date:10/6/2017)... (PRWEB) , ... October 06, 2017 , ... ... host a lunch discussion and webinar on INSIGhT, the first-ever adaptive clinical trial ... Investigator, Dana-Farber Cancer Institute. The event is free and open to the public, ...
Breaking Biology Technology: