Navigation Links
Circles Of DNA Might Help Predict Success Of Stem Cell Transplantation

during a "mix-and-match" rearrangement of these genes into any one of countless combinations. The rings represent sections of DNA cut out of chromosomes during the mixing and matching of genes that are chosen to build a particular receptor. Each T cell uses the resulting combination of genes to make a receptor that lets the cell recognize a specific target. When stimulated to multiply, each of those cells produce an army of immune cells against their designated target.

Specific infectious organisms or other foreign substances stimulate T cells to divide and multiply in order to form an attacking army. However, the sjTRECs don't multiply when the original T cells divide and multiply. Instead, the more T cells that are produced in the blood as the parent cells containing sjTRECs divide and produce daughter cells, the more the sjTRECs in those original T cells get "diluted" within the growing army of these immune cells. This proves that high levels of sjTREC in blood means that a large number of stem cells have been converted to parent T cells--each of which targets a specific foreign substance, according to Rupert Handgretinger, M.D., Ph.D., director of Stem Cell Transplantation at St. Jude and co-director of the Transplantation and Gene Therapy Program.

"sjTRECs appear only after the gene shuffling has successfully occurred in the parent cell," Handgretinger said. "So if we extract large numbers of sjTRECs from T cells in the blood of a patient about to undergo a stem cell transplant, that's a good sign. It means the patient's thymus is a good T-cell factory."

Handgretinger is the senior author of the Blood report.

The St. Jude team tested levels of sjTREC in the blood of 77 healthy donors who provided stem cells to their siblings. The researchers also tested 244 samples from 26 of the recipients themselves. The recipients had been treated for either white cell cancers (e.g., acute lymphoblastic leukemia) or red cell diseases (e.g., s
'"/>

Source:St. Jude Children鈥檚 Research Hospital


Page: 1 2 3 4

Related biology news :

1. Protein That Promotes Survival Of Stem Cells Might Be Key To Poor Leukemia Prognosis
2. Gene Signatures Predict Interferon Response For Multiple Sclerosis Patients
3. Chromosome Deletion Predicts Aggressive Neuroblastoma
4. Measuring Enzymes At End Of Cancer Pathway Predicts Outcome Of Tarceva, Taxol
5. Analysis Of Human Genome To Predict The Development Of Illnesses
6. Computational Tool Predicts How Drugs Work In Cells, Advancing Efforts To Design Better Medicines
7. Predicting success
8. Predicting chemotherapy outcome
9. Predicting successful outcomes in living-donor liver transplants
10. World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics
11. Successful Test Of Single Molecule Switch Opens The Door To Biomolecular Electronics
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Circles DNA Might Help Predict Success Stem Cell Transplantation

(Date:7/31/2014)... An international team of scientists from Spain, France, ... rove beetle that is the oldest definitive member ... found in amber. The discovery and description were ... phase-contrast X-ray synchrotron imaging technique, which allows the ... amber. The new species is described in the ...
(Date:7/31/2014)... Edmond Becquerel first discovered the photovoltaic effect in 1839, ... power of sunlight for its own purposes. In a ... of the FASEB Journal , scientists ... power of sunlight by focusing on a naturally occurring ... evolution. This conservationor persistence over time and across speciessuggests ...
(Date:7/31/2014)... people are familiar with Hibiscus flowers- they are ... they are commonly planted in the landscape. Some, ... are endangered species. , Only a relatively few ... of an equally beautiful and intriguing related group ... "brother of Hibiscus". , Brother of Hibiscus species ...
Breaking Biology News(10 mins):Scientists shine bright new light on how living things capture energy from the sun 2Brother of Hibiscus is found alive and well on Maui 2
... researchers is examining a new vaccine method that may ... and his team of researchers is hoping to find ... smaller doses and require only one trip to the ... prepared from killed bacteria. The vaccinated person,s immune system ...
... of the future plan to confront the greatest scientific, ... inhabitants? This is the question being addressed at the ... Status and Perspective held by the Deutsche Forschungsgemeinschaft (DFG, ... Promotion of Science (JSPS), taking place in Hamburg this ...
... in French . A research ... Universitys Department of Microbiology and Immunology has discovered that ... the bodys autoimmune reactions may lose their effectiveness and ... type 1 diabetes. The study conducted on non-obese ...
Cached Biology News:Iowa State researchers look for smaller, cheaper, 1-dose vaccines 2Japanese and German researchers meet to discuss climate change 2Japanese and German researchers meet to discuss climate change 3Type 1 diabetes triggered by 'lazy' regulatory T-cells: McGill researchers 2
(Date:7/31/2014)... Colo. , July 31, 2014 ... awardee today with $25,000 to fund a translational ... inception in 2011, the gift was presented at ... Annual Meeting in Colorado Springs, ... specialize in neurointerventional approaches to neurovascular conditions, SNIS ...
(Date:7/31/2014)... Graphite Metallizing Corporation announces GRAPHALLOY® ... bearings are uniquely suited to prevent loss of lubrication ... the high temperatures . , Recently, a manufacturer ... engineers at Graphite Metallizing to overcome problems with movement ... operation, pans containing blocks of powder mixture are loaded ...
(Date:7/31/2014)... DUBLIN , July 31, 2014 ... the "Global Genomics Market 2014-2018" report to ... Genomics is the study of the genetic ... to be a strong basis for the discovery and ... of human diseases or health conditions. Genomics is supported ...
(Date:7/31/2014)... -- Smith & Nephew (LSE:SN, NYSE: SNN ... its entry into the forefoot market with the ... Comprised of three separate repair options, the HAT-TRICK ... and reconstruction, a metatarsal osteotomy guide, and a ... also known as hammer toe correction. ...
Breaking Biology Technology:SNIS Foundation Bestows First Grant Award For Cutting-Edge NeuroInterventional Research 2SNIS Foundation Bestows First Grant Award For Cutting-Edge NeuroInterventional Research 3Graphite Metallizing Announces Bearings for High Temperature Oven Applications 2Graphite Metallizing Announces Bearings for High Temperature Oven Applications 3Global Genomics Market 2014-2018: Key Vendors are F. Hoffmann-La Roche, Life Technologies, Qiagen and Illumina 2Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 2Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 3Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 4
... SAN DIEGO, Oct. 27 BioAtom Inc. (private) announced,today ... Investor Conference on,Tuesday, October 28, 2008 at 2:30 PM ... in San Diego, California., Myron Karasik, M.B.A., C.M.C., ... of BioAtom Inc. of Costa Mesa, CA, dedicated,to development ...
... YORK, Oct. 24 The day of true ... study confirms the efficacy of a,revolutionary egg selection ... a viable and reliable fertility preservation option., ... ReproCure, a,vanguard genetics products company, this process increases ...
... /PRNewswire-FirstCall/ - AEterna Zentaris Inc.,(NASDAQ: AEZS ; ... therapy and oncology, today announced that it received ... Zentaris that during the 30,consecutive business days prior ... the,Company,s common shares had closed below the US$1.00 ...
Cached Biology Technology:BioAtom Inc. To Present at BIOCOM Investor Conference 2008 2Breakthrough Technology Takes Egg Freezing from Myth to Dependable Reality 2Breakthrough Technology Takes Egg Freezing from Myth to Dependable Reality 3Breakthrough Technology Takes Egg Freezing from Myth to Dependable Reality 4AEterna Zentaris Receives Notification from Nasdaq Relating to Minimum Bid Price 2AEterna Zentaris Receives Notification from Nasdaq Relating to Minimum Bid Price 3