Navigation Links
Circadian gene helps the brain predict mealtime

By investigating how animals can predict the timing of food availability, researchers have identified the first gene critical for anticipation of mealtime. This gene, called Period 2, is a key component of the circadian time-keeping system. The findings are reported by Urs Albrecht of the University of Fribourg and Etienne Challet of the University Louis Pasteur/CNRS and colleagues in the October 24th issue of the journal Current Biology, published by Cell Press.

A daily scheduled meal is a potent time-giving cue that can reset the physiological timing of most organs, including the liver. In terms of animal behavior, a daily scheduled meal elicits anticipatory bouts of locomotor activity and changes in body temperature. These food-anticipatory behaviors are believed to be under the control of a food-entrainable mechanism--that is, a timing mechanism within the body that is set by food intake--but how this mechanism works at the molecular level is unknown.

In the new work, the researchers have found the first evidence that a single gene mutation can render mice totally unable to predict the time of food availability. Studying mice, they found that this lack of food anticipation at both behavioral and physiological levels is specifically associated with a mutation in the Period 2 gene, a gene that previous work had shown to play an important role in the brain's ability to run its central circadian clock according to daylight.

The researchers found that, interestingly, synchronization of timing between organs by scheduled meals is not affected by the Period 2 mutation, indicating that this gene is not crucial for scheduled food availability to affect the physiological coordination of tissues outside the central nervous system.

The authors of the study point out that the work they report provides a tool for investigating the brain's cerebral clockwork responsible for predicting mealtime--with this tool in hand, it will be possible
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Jumping gene helps explain immune systems abilities
2. Protein helps regulate the genes of embryonic stem cells
3. Scientists reveal the shape of a protein that helps retroviruses break into cells
4. Thai spice helps cut blood sugar swings
5. Chemists synthesize molecule that helps body battle cancers, malaria
6. Ancient DNA helps clarify the origins of two extinct New World horse species
7. Massey Cancer Center researcher helps to identify a piece of the cancer puzzle
8. Study: Well-known protein helps stem cells become secretory cells
9. Beyond genes: Lipid helps cell wall protein fold into proper shape
10. Simple sea sponge helps scientists understand tissue rejection
11. New technique helps identify multiple DNA regulatory sites
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Circadian gene helps the brain predict mealtime

(Date:7/11/2014)... A new report from the Wildlife Conservation Society ... only help economically valuable species such as lobster, ... also help re-colonize nearby reef areas. , The ... a systematic review of research literature from no-take ... by Dr. Craig Dahlgren, a recognized expert in ...
(Date:7/11/2014)... Mills Canyon fire started near the City of Entiat ... local resources, the fire quickly grew to over 1,000 ... of the fire is under investigation by the Washington ... working with existing local resources in developing fire control ... Service (USFS), Washington State Department of Natural Resources, (WA ...
(Date:7/11/2014)... available in German . ... that uses the refraction of X-rays through a specimen ... with this method are often of much higher quality ... team of Prof. Franz Pfeiffer are particularly interested in ... including X-ray phase-contrast imaging. One main goal is ...
Breaking Biology News(10 mins):Belize's lobster, conch, and fish populations rebuild in no-take zones 2New simple setup for X-ray phase contrast 2
... the planet. They thrive in almost every known environment, ... that provide the capabilities essential for survival. These genetic ... mutation and exchange of genes and other bits of ... which then becomes an intrinsic part of the genome. ...
... URBANA - When University of Illinois researchers surveyed over 3,500 ... accurately, and overweight and obese men were more likely to ... because the first step in dealing with a weight problem ... U of I professor of food science and human nutrition. ...
... Most medical imaging equipment is not designed with overweight and ... be exposed to higher levels of radiation during routine X-ray ... Polytechnic Institute is the first to calculate exactly how much ... results show the internal organs of obese men receive 62 ...
Cached Biology News:Study shows unified process of evolution in bacteria and sexual eukaryotes 2Study shows unified process of evolution in bacteria and sexual eukaryotes 3Misperception of weight is an important barrier to weight loss 2Obese patients face higher radiation exposure from CT scans -- but new technology can help 2
(Date:7/10/2014)... , July 10, 2014 On ... Dmitry Medvedev , presented Russia,s ... BIOCAD . The Company is developing a unique project ... project BIOCAD develops a number of innovative drugs based ... diseases. The ceremony took place at the International Exhibition ...
(Date:7/10/2014)... 2014 /PRNewswire-iReach/ -- Tute Genomics, the leader ... an agreement with Lineagen, Inc., to provide ... Dx PLUS.  Lineagen, focused on the ... currently offers FirstStep Dx PLUS, a ... by healthcare providers as a first-line genetic ...
(Date:7/10/2014)... THOUSAND OAKS, Calif., July 10, 2014   Ceres, ... biotechnology and seed company, announced today financial results for ... an update on its business. Ceres reported ... progress in product performance this growing season in Brazil, ... that affected the company,s sorghum evaluation areas for part ...
(Date:7/10/2014)... Adelaide research may help in the fight against terrorism ... tiny quantities of explosives with the use of light ... Sensors and Actuators B: Chemical , the researchers ... explosives in concentrations as low as 6.3 ppm (parts ... a few minutes. , "Traditionally explosives detection has involved ...
Breaking Biology Technology:Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9Detecting trace amounts of explosives with light 2
... - NovaScan, an early-stage medical imaging company developing what ... of breast cancer, had to bypass angel tax credits from ... for its emerging technology. , ,The company instead has raised ... a state loan, and grants. , ,According to CEO Larry ...
... rural Wisconsin, one company is earning their bread and ... Networks, Inc. , a global satellite communications provider, has ... , a satellite-based broadband access provider. , ,IsoTropic operates ... set on 21 acres in rural Wisconsin, and it ...
... Last week, the nation marked the five-year anniversary of ... restrictions have unquestionably set back the progress of this ... Congress passed legislation that would have lifted President Bush's ... ones are suffering from a wide range of debilitating ...
Cached Biology Technology:NovaScan decides against tax credits 2Rural company works to improve broadband 2Stem cell research holds the promise for tomorrow 2Stem cell research holds the promise for tomorrow 3
... is the only PCR system that ensures ... time. It provides accuracy, consistency, and dependability ... the property of the DNA templates. This ... a unique blend of thermostable enzymes that ...
Special grade: for molecular biology Density: 1.000 g/mL (20 C)...
... to meet the needs of ... component-free medium supports fast cell ... densities, while maintaining high cell ... production using the Baculovirus Expression ...
... This CLS number ... number, created to easily ... If showing no availability ... the old Sigma-Aldrich number ...
Biology Products: