Navigation Links
Circadian gene helps the brain predict mealtime

By investigating how animals can predict the timing of food availability, researchers have identified the first gene critical for anticipation of mealtime. This gene, called Period 2, is a key component of the circadian time-keeping system. The findings are reported by Urs Albrecht of the University of Fribourg and Etienne Challet of the University Louis Pasteur/CNRS and colleagues in the October 24th issue of the journal Current Biology, published by Cell Press.

A daily scheduled meal is a potent time-giving cue that can reset the physiological timing of most organs, including the liver. In terms of animal behavior, a daily scheduled meal elicits anticipatory bouts of locomotor activity and changes in body temperature. These food-anticipatory behaviors are believed to be under the control of a food-entrainable mechanism--that is, a timing mechanism within the body that is set by food intake--but how this mechanism works at the molecular level is unknown.

In the new work, the researchers have found the first evidence that a single gene mutation can render mice totally unable to predict the time of food availability. Studying mice, they found that this lack of food anticipation at both behavioral and physiological levels is specifically associated with a mutation in the Period 2 gene, a gene that previous work had shown to play an important role in the brain's ability to run its central circadian clock according to daylight.

The researchers found that, interestingly, synchronization of timing between organs by scheduled meals is not affected by the Period 2 mutation, indicating that this gene is not crucial for scheduled food availability to affect the physiological coordination of tissues outside the central nervous system.

The authors of the study point out that the work they report provides a tool for investigating the brain's cerebral clockwork responsible for predicting mealtime--with this tool in hand, it will be possible
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Jumping gene helps explain immune systems abilities
2. Protein helps regulate the genes of embryonic stem cells
3. Scientists reveal the shape of a protein that helps retroviruses break into cells
4. Thai spice helps cut blood sugar swings
5. Chemists synthesize molecule that helps body battle cancers, malaria
6. Ancient DNA helps clarify the origins of two extinct New World horse species
7. Massey Cancer Center researcher helps to identify a piece of the cancer puzzle
8. Study: Well-known protein helps stem cells become secretory cells
9. Beyond genes: Lipid helps cell wall protein fold into proper shape
10. Simple sea sponge helps scientists understand tissue rejection
11. New technique helps identify multiple DNA regulatory sites
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Circadian gene helps the brain predict mealtime

(Date:8/20/2014)... of Tennessee, Knoxville, research finds life can persist in ... was part of a team that examined waters and ... ice sheet and found the extreme environment supports microbial ... Jill Mikucki and her colleagues has implications for life ... the solar system. The findings are published in the ...
(Date:8/20/2014)... Issue Serious allergic reactions to food often ... some children.    What you should know ... and this number may be increasing, especially among children. Up ... food allergies.  The symptoms of allergic reactions ... difficulties and loss of consciousness. Symptoms can also develop at ...
(Date:8/20/2014)... Scientists from the University of Tbingen, Arizona State University, ... and Public Health Institute (Swiss TPH) isolated Mycobacterium ... at least 1000 years old. The pathogen is a ... only occasionally causes disease in humans today. These researchers ... the Peruvian coast. "The link to sea lions was ...
Breaking Biology News(10 mins):University of Tennessee research uncovers subglacial life beneath Antarctic ice sheet 2Information Update - Allergens and food safety at school - What's in your child's lunch? 2Information Update - Allergens and food safety at school - What's in your child's lunch? 3
... and going to work is hard enough every day. But ... of your job down the smallest detail and the ... of credentials might mean starting from scratch. These are the ... make U.S. homes more energy efficient. A recent collaboration ...
... called ADAP (adhesion and degranulation-promoting adaptor protein) is able ... new University of Cambridge research reveals. The researchers, who ... discovery will lead to new ways of combatting HIV. ... who led the research, said: "One exciting aspect about ...
... Oct. 1, 2013  Pfenex Inc. today announced that the ... Biomedical Advanced Research and Development Authority (BARDA), has modified ... with the existing Pfenex contractual relationship begun in July, ... funding to support the development of a next generation ...
Cached Biology News:Weatherization work guidelines launched 2Weatherization work guidelines launched 3Weatherization work guidelines launched 4Weatherization work guidelines launched 5Weatherization work guidelines launched 6New target to fight HIV infection identified 2Biomedical Advanced Research and Development Authority (BARDA) Exercises Option with Pfenex Inc. To Extend Contract and Increase Funding for the Development of a Recombinant Protective Antigen (rPA) Based Anthrax Vaccine 2
(Date:8/20/2014)... licensed to biotechnology firms has revealed early bottlenecks ... roadblocks, the researchers suggest that better communication of ... lead to faster commercialization down the road. , ... in university laboratories and licensed to biotechnology firms. ... have a high failure rate. But a new ...
(Date:8/20/2014)... American Indians largely were wiped out by diseases such ... to the New World by European explorers., One report ... in the Americas shortly before Europeans arrived, and roughly ... But new research led by anthropological geneticists Anne Stone ... University of Tubingen in Germany indicates the diagnosis of ...
(Date:8/20/2014)... the first time, chemists have succeeded in measuring vibrational ... resolution. The study reveals how vibration of a single ... , The study was performed at the University ... the University of Jyvskyl works as a visiting fellow ... the study. The second team was lead by Professor ...
(Date:8/20/2014)... Fla. , Aug. 20, 2014 ... will host a conference call to provide an ... 2014Time:4:30 p.m. Eastern daylight timeDial-in numbers:(888) 505-4369 (U.S. ... 9126599 Live web cast: www.neurotropebioscience.com , under "Investor ... hours after completion through September 2, 2014 at ...
Breaking Biology Technology:Early bottlenecks in developing biopharmaceutical products delay commercialization 2Early bottlenecks in developing biopharmaceutical products delay commercialization 3Unusual discovery leads to fascinating tuberculosis theory 2Unusual discovery leads to fascinating tuberculosis theory 3Seeing a molecule breathe 2Neurotrope To Host Conference Call 2
... season on CEOs lately but when luminaries like management god ... something real and serious is taking place. Heres what Herr ... January 12, 2004 issue of Fortune Magazine, the compensation inflation ... of the management team. In an executive program I have ...
... Wis. The recent onslaught of e-mail viruses, overabundant ... for computer user protection. In light of this, ... Wisconsin companies, recently began offering new computer security technologies ... spam cost U.S. corporations $8.9 billion dollars in 2002 ...
... DEMO 2004 reaches its final week, I promised I'd share ... not just at DEMO, but in the week ahead. , ... it feels a lot like the enterprise market some 20 ... departments in the early 80s) is acutely focused on the ...
Cached Biology Technology:The CEO Crisis 2Wisconsin Telcos Offer New Internet Security Solutions 2The Enterprise and the Individual 2The Enterprise and the Individual 3
Goat polyclonal to STMN2 ( Abpromise for all tested applications). Antigen: Synthetic peptide: AKTAMAYKEK, corresponding to C terminal amino acids 2-11 of STMN2. Entrez Gene ID: 11075 Swi...
Mouse monoclonal antibody to PAEP - progestagen-associated endometrial protein (placental protein 14, pregnancy-associated endometrial alpha-2-globulin, alpha uterine protein)...
Mouse polyclonal antibody to MCFD2 - multiple coagulation factor deficiency 2...
Volume adapter mounts on top of the 96 well FiltrEX filter plate and allows larger volumes (1mL) to be applied to each well in a filter plate. Adapters are nonsterile....
Biology Products: