Navigation Links
Chromosome Deletion Predicts Aggressive Neuroblastoma

When genes are deleted on a particular section of chromosome 11, the result is an aggressive form of the childhood cancer neuroblastoma. A new study suggests that detecting this genetic deletion during the initial evaluation of children with neuroblastoma may indicate to physicians that they should recommend a more aggressive regimen of chemotherapy to fight the cancer.

Edward F. Attiyeh, M.D., a pediatric oncology fellow at The Children's Hospital of Philadelphia, reported on a study of 915 patients in a presentation today at the American Society of Clinical Oncology annual meeting in Orlando, Fla. The patients were children with primary neuroblastoma treated at Children's Oncology Group (COG) centers. The COG is a National Institutes of Health-funded multicenter clinical research organization that supports clinical trials for pediatric cancer patients.

Neuroblastoma, which accounts for 10 percent of all pediatric cancers, often occurs as a solid tumor in a child's abdomen or chest. Some cases of neuroblastoma are low risk, and resolve after surgeons remove the tumor. Other cases are more aggressive, and are more likely to resist initial treatment, or to cause a relapse. Identifying the correct risk level allows doctors to treat aggressive cancers appropriately, while not subjecting children with low-risk cancer to overtreatment.

Oncologists know that amplification, an abnormal increase in the number of copies, of a cancer-causing gene called MYCN heralds a high-risk, aggressive cancer. However, a significant number of neuroblastomas are aggressive without having amplified MYCN. "The deletion of genetic material on chromosome 11 may account for a significant percentage of these high-risk neuroblastomas," said Dr. Attiyeh.

It is unknown what causes the deletion of genes on chromosome 11, at a location designated chromosome 11q23. However, the loss of material at that site apparently removes the protective effect of a tumor suppressor g
'"/>

Source:Children's Hospital Of Philadelphia


Page: 1 2

Related biology news :

1. Needling Chromosomes Reveals Cell Division Secret
2. Measuring Enzymes At End Of Cancer Pathway Predicts Outcome Of Tarceva, Taxol
3. Computational Tool Predicts How Drugs Work In Cells, Advancing Efforts To Design Better Medicines
4. Aggressive aquatic species invading Great Lakes
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Chromosome Deletion Predicts Aggressive Neuroblastoma

(Date:8/21/2014)... , Saturday to Wednesday, Oct. 18-22, 2014 , ... W. Harbor Drive, San Diego, CA 92101 , ... and other presentations of the latest research in ... plenary session featuring high-scoring abstracts on rare genetic ... various cancers, and treatment for sun sensitivity (Saturday, ...
(Date:8/21/2014)... A team of researchers at Louisiana Tech ... using affordable, consumer-grade 3D printers and materials ... contain antibacterial and chemotherapeutic compounds for targeted ... doctoral students and research faculty from Louisiana ... collaborated to create filament extruders that can ...
(Date:8/21/2014)... pancreatitis involves the pancreas digesting itself resulting in severe ... the UK around 20,000 patients are diagnosed with the ... cure and treatment is restricted to intravenous fluid and ... Faculty of Life Sciences, who led the research, said ... from gall stones and excessive alcohol intake combined with ...
Breaking Biology News(10 mins):American Society of Human Genetics 2014 Annual Meeting 2Louisiana Tech University researchers use 3D printers to create custom medical implants 2Louisiana Tech University researchers use 3D printers to create custom medical implants 3Insulin offers new hope for the treatment of acute pancreatitis 2
... bacterium or virus starts rummaging through the contents of a ... host,s DNA strands, it can alter the host,s biological course. ... particular sequences of DNA, to bend, kink and twist the ... any part of a DNA strand, but these seemingly random ...
... , HOUSTON -- (Aug. 30, 2012) -- The threads of ... biology are beginning to unravel, thanks to a new investigation ... Texas MD Anderson Cancer Center. In new research published ... Oleg Igoshin and MD Anderson,s Christian Ray offer a possible ...
... Bacteria in hyenas, scent glands may be the ... the current issue of Scientific Reports , show ... and the distinct microbial communities that reside in their ... and Michigan State University postdoctoral researcher. "A critical ...
Cached Biology News:Biophysicists unravel secrets of genetic switch 2Biophysicists unravel secrets of genetic switch 3Rice, MD Anderson scientists probe mystery of operon evolution 2Rice, MD Anderson scientists probe mystery of operon evolution 3Rice, MD Anderson scientists probe mystery of operon evolution 4Microbes help hyenas communicate via scent 2
(Date:8/21/2014)... YORK , Aug. 21, 2014 ... congratulates Immune Pharmaceuticals Inc., a biotechnology company, on ... Market.  Immune previously traded on OTCQX®, the best ... by OTC Markets Group. Logo - ... Pharmaceuticals on the successful execution of its growth ...
(Date:8/21/2014)... Aug. 21, 2014  Four-dimensional (4-D) printing develops ... on external stimuli such as changes in temperature. ... disruptive effect in multiple industries.  In the near ... by printing objects ranging from human organs to ... Logo - http://photos.prnewswire.com/prnh/20140820/138289 ...
(Date:8/21/2014)... Bulgaria (PRWEB) August 21, 2014 ... released today by Ontotext . Now the ... semantic analysis of structured and unstructured data is available ... the cost of enterprise technology. Organizations that do not ... for data management can use S4 since there is ...
(Date:8/21/2014)... Boston, MA (PRWEB) August 21, 2014 ... collaboration company, has been recognized as one of ... 500 | 5000 magazine for the 2nd consecutive ... on its 33rd annual Inc. 500|5000, an exclusive ... list represents the most comprehensive look at the ...
Breaking Biology Technology:OTC Markets Group Congratulates Immune Pharmaceuticals on NASDAQ Listing 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 3Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 4Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 3Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 4SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 2SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 3
... , , ... , , , Duplications and ... different methods are used for detecting such rearrangements,most based on either ... accurate, but very labour intensive and expensive,while quantitative PCR methods are ...
... , ... , , , Slab ... the separated bands,of an unknown sample to a known,standard (size ... estimated. The Agilent,2100 bioanalyzer is an instrument,which utilizes LabChip,technology to ...
... , , ... , , , , Gene expression ... for analyzing cellular behavior in a micro,scale and is used in ... of RNA from specific cell,populations out of their surrounding tissue environment. ...
Cached Biology Technology:Rapid detection of genomic,duplications and deletions using,the Agilent 2100 bioanalyzer 2Rapid detection of genomic,duplications and deletions using,the Agilent 2100 bioanalyzer 3Rapid detection of genomic,duplications and deletions using,the Agilent 2100 bioanalyzer 4Rapid detection of genomic,duplications and deletions using,the Agilent 2100 bioanalyzer 5High resolution DNA analysis with the,DNA 500 and DNA 1000 LabChip kits 2High resolution DNA analysis with the,DNA 500 and DNA 1000 LabChip kits 3High resolution DNA analysis with the,DNA 500 and DNA 1000 LabChip kits 4High resolution DNA analysis with the,DNA 500 and DNA 1000 LabChip kits 5Quality assurance of RNA derived from,laser microdissected tissue samples,obtained by the PALM MicroBeam System,using the RNA 6000 Pico LabChip kit. 2Quality assurance of RNA derived from,laser microdissected tissue samples,obtained by the PALM MicroBeam System,using the RNA 6000 Pico LabChip kit. 3Quality assurance of RNA derived from,laser microdissected tissue samples,obtained by the PALM MicroBeam System,using the RNA 6000 Pico LabChip kit. 4Quality assurance of RNA derived from,laser microdissected tissue samples,obtained by the PALM MicroBeam System,using the RNA 6000 Pico LabChip kit. 5Quality assurance of RNA derived from,laser microdissected tissue samples,obtained by the PALM MicroBeam System,using the RNA 6000 Pico LabChip kit. 6Quality assurance of RNA derived from,laser microdissected tissue samples,obtained by the PALM MicroBeam System,using the RNA 6000 Pico LabChip kit. 7Quality assurance of RNA derived from,laser microdissected tissue samples,obtained by the PALM MicroBeam System,using the RNA 6000 Pico LabChip kit. 8
SH3 Proteins II Sampler Kit 10g each...
... reagent for Virus isolation ... unique water insoluble Elastomeric ... and chaotropes; Engineered to ... viruses while preserving infectivity; ...
Golgi Sampler Kit 10g each...
Caveolin Sampler Kit 10g each...
Biology Products: