Navigation Links
Chromosomal microarray analysis proves accurate

Two years and more than 2,000 samples after researchers at Baylor College of Medicine started to use a new gene-chip technology called chromosomal microarray analysis to look for potential genetic abnormalities in children, they find that it is remarkably sensitive in detecting abnormalities in individual chromosomes, according to a report that appears online today in the journal Public Library of Science ONE.

"Chromosomal microarray analysis is far better at picking up these abnormalities than other common methods," said Dr. Arthur Beaudet, chair of the department of molecular and human genetics at BCM and an author of the paper. "It allows us to identify the source of abnormalities in many cases."

He said the technique does not help with identifying the problem in all children, but there is a five to 12 percent chance that it will identify an abnormality in children with various disabilities where the previous chromosomal testing did not. This study involved two versions of the test, and the newer version was more successful in identifying chromosomal abnormalities.

The targeted microarray analysis used here is essentially a gene chip method of assessing the makeup of chromosomes in a particular part of the human genome (genetic blueprint).

In areas of the genome, there are portions of the genetic material that show imbalances because they are duplicated or deleted abnormally with gains and losses of genetic information.

"If these changes are big enough, they can cause significant disabilities," said Beaudet.

The technique used is also much more efficient, making it possible to do the equivalent of a couple of thousand of more common testing methods in one test.

"If you tried to do these individually, it would be cost prohibitive," said Beaudet. Currently, chromosomal microarray analysis costs from $950 to $1,500.

In the current study, Beaudet and his colleagues analyzed the results from 2,513 samples taken from patients referred to the laboratory because they had physical or mental features that suggested one of these repetitions or deletions as a genetic cause. The array technique identified the chromosomal problem (too much or too little genetic material in a particular spot) in 8.5 percent of the total group of patients studied. This high resolution genome analysis promise to transform the practice of clinical genetics," said Beaudet.

More important, the technique found abnormalities in 5.2 percent of patients for whom more traditional techniques had not identified the genetic cause.

"We are constantly improving the test," said Beaudet. Eventually, he said, he hopes to develop tests that will look at greater areas of the genome. However, he said, there are many areas of the genome where all normal people have gains or losses of genetic material compared to the average genome.

"It is difficult to determine if it is causing a problem or not," said Beaudet. Comparing a child’s genome to that of the parents can often determine if this is a normal familial variation or a disease-causing one.
'"/>

Source:Baylor College of Medicine


Related biology news :

1. Chromosomal abnormalities in sperm higher after vasectomy reversal
2. An entropy-based gene selection method for cancer classification using microarray data
3. Genrate: a generative model that finds and scores new genes and exons in genomic microarray data
4. Different microarray systems more alike than previously thought
5. Agilent Technologies releases probe sequence, annotation information for all its commercial gene expression microarrays
6. Agilent Technologies introduces advanced zebrafish, mouse microarrays for stem cell and developmental biology research
7. Carnegie Mellon U. transforms DNA microarrays with standard Internet communications tool
8. NIH neuroscience microarray consortium launches high-throughput genotyping services
9. GATA: a graphic alignment tool for comparative sequence analysis
10. Global analysis of membrane proteins
11. Doctors closer to using gene analysis to help trauma patients

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/13/2017)... , Feb. 13, 2017  RSA Conference -- RSA, ... that is designed to enhance fraud detection and ... in the RSA Fraud & Risk Intelligence Suite. ... to leverage additional insights from internal and external ... better protect their customers from targeted cybercrime attacks. ...
(Date:2/10/2017)... -- Research and Markets has announced the ... Scientific and Commercial Aspects" to their offering. ... Biomarkers play ... therapy for selection of treatment as well for monitoring the ... disease in modern medicine. Biochip/microarray technologies and next generation sequencing ...
(Date:2/8/2017)... YORK , Feb. 8, 2017 About ... individual,s voice to match it against a stored ... such as pitch, cadence, and tone are compared ... require minimal hardware installation, as most PCs already ... for different transactions. Voice recognition biometrics are most ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... --  Boston Biomedical , an industry leader in the ... stemness pathways, today announced its Board of Directors has ... Officer, effective April 24, 2017. Ms. ... FACP, who has led Boston Biomedical since he founded ... Biomedical has grown from a "garage startup" without technology ...
(Date:3/22/2017)... ... 2017 , ... Benchworks CEO Thad L. Bench Sr. will participate ... 23-24 in San Diego. The event is a gathering of executive leadership from companies ... President Christian Meyer will also participate in the forum. Participants will discuss the future ...
(Date:3/22/2017)... WI (PRWEB) , ... March 22, 2017 , ... The ... scientific research agencies as outlined in the Administration’s recently published fiscal year 2018 budget ... the National Institutes of Health (NIH) by $5.8 billion or roughly 20% of its ...
(Date:3/22/2017)...   Invitae Corporation (NYSE: NVTA), one ... announced the availability of a new genetic test ... (SMA) , a neuromuscular disease that is one ... as well as a significant cause of progressive ... during the American College of Medical Genetics (ACMG) ...
Breaking Biology Technology: