Navigation Links
Chromosomal abnormalities in sperm higher after vasectomy reversal

Men who have had a vasectomy reversed have a very much greater rate of chromosomal abnormalities in their sperm than do normal fertile men, a scientist told the 22nd annual conference of the European Society of Human Reproduction and Embryology in Prague, Czech Republic on Wednesday 21 June 2006. Professor Nares Sukchareon, of the Department of Obstetrics and Gynaecology, Chulalongkorn University, Bangkok, Thailand, said that doctors needed to be aware of this problem and monitor carefully children born as a result, particularly if ART was involved.

Professor Sukchareon and his team had been studying men with obstructive azoospermia, a condition where sperm are created but cannot be mixed with the ejaculatory fluid due to a physical obstruction (such as a vasectomy). He found that they had high rates of chromosomal aneuploidy (where an abnormal number of specific chromosomes or chromosome sets exist within the nucleus of the cell) and diploidy (containing two sets of chromosomes ?unlike most cells in the body, the sex cells should only contain one set of chromosomes.

"The rate of abnormality was about 10 times higher than the aneuploidy and diploidy rate in normal fertile men", said Professor Sukchareon. "This raised a lot of questions, so we decided to study the rates of these abnormalities in ejaculated sperm after vasectomy reversal. If these sperm continued to have a high rate of aneuploidy and diploidy, we would know that obstruction by vasectomy must affect spermatogenesis in the longer term."

The scientists found a significant correlation between the duration of the obstruction in post vasectomy-reversal men and the number of abnormal sperm, and also between the time interval after vasectomy reversal and the total sex chromosome aneuploidy rate ?i.e. the long ago the reversal the better the chances of producing normal sperm.

"This study raises a lot of questions", said Professor Sukcharoen. "Is the abnormal spermato genesis reversible, and if so, how long will it take before things get back to normal? Perhaps more importantly, will babies born after vasectomy reversal ?either conceived naturally or by ART ?have problems themselves?"

To date there have been no studies looking at these questions, he said, and his team are beginning the follow-up research. "We are collecting sperm during vasectomy reversal operations and will compare the aneuploidy rate of these and of the sperm we will collect each month in the future from the same men. This will help us understand what the dangers are. But in the meantime, I think that doctors need to be very aware of the possibility that babies born after vasectomy reversal may have problems."

Their findings may not affect babies conceived naturally after such a procedure, says Professor Sukchareon, since the female genital tract may select the best sperm for fertilisation. "But this is still uncertain, and until we know more it would probably be safer to freeze ejaculated sperm before vasectomy. We need a lot more evidence and research on this issue before we can be certain of avoiding the dangers."


Source:European Society for Human Reproduction and Embryology

Related biology news :

1. Chromosomal microarray analysis proves accurate
2. North & South American researchers find architectural abnormalities in T. cruzi ribosome
3. Environmental chemical cocktail may sabotage sperm
4. Human embryonic stem cells have the potential to develop into eggs and sperm in the laboratory
5. UK sperm donor crisis
6. Protein translation in sperm
7. How sperm crack the whip
8. Ecologists home in on how sperm whales find their prey
9. Study links high levels of nitric oxide to infertility and sperm DNA damage
10. Even when faint, ovary scent draws sperm cells
11. Single molecular mark seen as pivotal for genome compaction in spores and sperm
Post Your Comments:

(Date:6/9/2016)... 9, 2016 Paris Police ... video security solution to ensure the safety of people and ... during the major tournament Teleste, an international technology ... services, announced today that its video security solution will be ... back up public safety across the country. The system roll-out ...
(Date:6/2/2016)... LONDON , June 2, 2016 ... has awarded the 44 million US Dollar project, ... Security Embossed Vehicle Plates including Personalization, Enrolment, and IT Infrastructure ... world leader in the production and implementation of Identity Management ... in January, however Decatur was selected ...
(Date:6/1/2016)... June 1, 2016 Favorable Government ... Administration and Criminal Identification to Boost Global Biometrics System ... released TechSci Research report, " Global Biometrics Market ... Forecast and Opportunities, 2011 - 2021", the global biometrics ... 2021, on account of growing security concerns across various ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, the Industry Network ... Supplyframe Design Lab . Located in Pasadena, Calif., the Design Lab’s mission is ... projects are designed, built and brought to market. , The Design Lab is ...
(Date:6/23/2016)...  Blueprint Bio, a company dedicated to identifying, protecting ... has closed its Series A funding round, according to ... "We have received a commitment from Forentis Fund that ... meet our current goals," stated Matthew Nunez . ... complete validation on the current projects in our pipeline, ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... regulatory and technical consulting, provides a free webinar on Performing Quality ... 13, 2016 at 12pm CT at no charge. , Incomplete investigations are still ...
(Date:6/22/2016)... 2016 Cell Applications, Inc. and StemoniX ... produce up to one billion human induced pluripotent ... week. These high-quality, consistent stem cells enable researchers ... spend more time doing meaningful, relevant research. This ... manufacturing process that produces affordable, reliable HiPSC for ...
Breaking Biology Technology: