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Chromosomal abnormalities in sperm higher after vasectomy reversal

Men who have had a vasectomy reversed have a very much greater rate of chromosomal abnormalities in their sperm than do normal fertile men, a scientist told the 22nd annual conference of the European Society of Human Reproduction and Embryology in Prague, Czech Republic on Wednesday 21 June 2006. Professor Nares Sukchareon, of the Department of Obstetrics and Gynaecology, Chulalongkorn University, Bangkok, Thailand, said that doctors needed to be aware of this problem and monitor carefully children born as a result, particularly if ART was involved.

Professor Sukchareon and his team had been studying men with obstructive azoospermia, a condition where sperm are created but cannot be mixed with the ejaculatory fluid due to a physical obstruction (such as a vasectomy). He found that they had high rates of chromosomal aneuploidy (where an abnormal number of specific chromosomes or chromosome sets exist within the nucleus of the cell) and diploidy (containing two sets of chromosomes ?unlike most cells in the body, the sex cells should only contain one set of chromosomes.

"The rate of abnormality was about 10 times higher than the aneuploidy and diploidy rate in normal fertile men", said Professor Sukchareon. "This raised a lot of questions, so we decided to study the rates of these abnormalities in ejaculated sperm after vasectomy reversal. If these sperm continued to have a high rate of aneuploidy and diploidy, we would know that obstruction by vasectomy must affect spermatogenesis in the longer term."

The scientists found a significant correlation between the duration of the obstruction in post vasectomy-reversal men and the number of abnormal sperm, and also between the time interval after vasectomy reversal and the total sex chromosome aneuploidy rate ?i.e. the long ago the reversal the better the chances of producing normal sperm.

"This study raises a lot of questions", said Professor Sukcharoen. "Is the abnormal spermato
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Source:European Society for Human Reproduction and Embryology


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