Navigation Links
Cholesterol gets 'thumbs up' for role in digit development

to have a cholesterol molecule attached to work properly.

"In fact, Sonic hedgehog is the only protein known to be modified by cholesterol,"Chiang said.

Because cholesterol is typically found in cell membranes and thought to 'tether' proteins to cells, scientists speculated that cholesterol might inhibit the movement of Sonic hedgehog through the developing tissue. This unique modification might explain why concentrations of the protein were high at the site of its production and then tapered off with increasing distance from the synthesis site.

But previous studies in mice suggested that cholesterol promoted the movement of Sonic hedgehog, a counterintuitive proposal given cholesterol's supposed tethering ability.

To try and clear up cholesterol's role in digit patterning and the Sonic hedgehog gradient, Chiang and colleagues created mice with an altered form of the Sonic hedgehog protein to which cholesterol cannot attach.

They found that mice lacking cholesterol-modified Sonic hedgehog developed with malformed and ectopic, or out of place, digits. The second, or "index,"digits were stunted and misshapen, appearing more similar to a thumb than a normal second digit.

The researchers also examined mice in which only half of their Sonic hedgehog proteins could attach to cholesterol. Those mice developed normal digits 2 through 5 (index through pinkie), but had duplication of these digits anteriorly.

The findings suggested that Sonic hedgehog without cholesterol traveled further than normal, triggering the anomalous digit duplications.

Chiang and colleagues confirmed this microscopically, showing that the protein spread out more evenly across the limb bud (a weaker gradient) in mice lacking cholesterol-modified Sonic hedgehog compared to normal animals.

"We found that, without cholesterol, Sonic hedgehog moves more readily, far from its site of synthesis, all the way to the anterior part
'"/>

Source:Vanderbilt University Medical Center


Page: 1 2 3

Related biology news :

1. Scientists create digital bacteria to forge advances in biomedical research
2. Free access to a digital library for developing countries
3. A much-needed shot in the arm for HIV vaccine development
4. Clam embryo study shows pollutant mixture adversely affects nerve cell development
5. Zebrafish may hold key to understanding human nerve cell development
6. Scientists identify new model Of NK cell development
7. Influenza vaccine uses insect cells to speed development
8. Liposome finding implies electrical effect on cell development
9. Multi-purpose protein regulates new protein synthesis and immune cell development
10. Unlike other mammals, newborn dolphins and orcas stay active 24/7 during first months of development
11. Scientists find microRNAs regulate plant development
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cholesterol gets thumbs for role digit development

(Date:12/22/2014)... , Dec. 22, 2014 Research and Markets ... of the "The Global Watermarking and Fingerprinting ... http://photos.prnewswire.com/prnh/20130307/600769 This ... media watermarking and fingerprinting markets. Watermarking aims to ...
(Date:12/19/2014)...   LaunchKey , the first decentralized mobile authentication and ... Things era, today announced the close of $3 million ... by Metamorphic Ventures with participation from ENIAC Ventures, Crosslink ... LaunchKey has raised $4 million to date, and will ...
(Date:12/17/2014)... DUBLIN , Dec. 16, 2014 Research and Markets ... of the "Global Chemical Sensor Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 One major trend upcoming in ... in biomedical applications. Chemical sensors help in recording of ...
Breaking Biology News(10 mins):The Global Watermarking and Fingerprinting Markets 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2
... Spanish and French researchers has undertaken a pioneer analysis ... Areas (MPA) in the Mediterranean and the impact that ... a guarantee for conserving this species., Mediterranean red coral ... jewellery since ancient times. But intensive fishing, particularly in ...
... The U.S. Environmental Protection Agency (EPA) has awarded ... their work in eight key environmental areas: monitoring ... drinking water monitoring, hazardous waste monitoring, water infrastructure, ... year, the companies received "proof of concept" awards ...
... Tufts University,s School of Arts and Sciences has received ... will house a Collaborative Cluster in Genome Structure and ... bring together experts in such areas as genome structure ... to focus on "genome to organism" research to advance ...
Cached Biology News:Marine protected areas conserve Mediterranean red coral 2EPA awards small businesses to develop new environmental technologies 2Tufts wins NCRR grant for Collaborative Cluster in Genome Structure and Developmental Patterning 2Tufts wins NCRR grant for Collaborative Cluster in Genome Structure and Developmental Patterning 3
(Date:12/24/2014)... , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, Inc. (NASDAQ: ... areas, announced the closing of an underwritten public offering of ... to an aggregate 3,500,000 shares of common stock, at an ... The warrants have a per share exercise price of $5.00, ...
(Date:12/24/2014)... “Preparative & Process Chromatography Market ... (Columns, Solvents, Buffers, Valves, Guages, Seals), Accessories, Services, ... Forecasts to 2019” provides a detailed overview of ... trends, and strategies impacting the preparative and process ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 ... designed to introduce cutting edge communication technology, provide ... platform upgrades. This webinar series demonstrates online communication ... to leverage web conferencing’s most innovative and powerful ...
(Date:12/24/2014)... The report provides basic information ... application and industry overview. This report also presents ... Production is separated by regions, technology and applications. ... downstream client survey, marketing channels, industry development trend ...
Breaking Biology Technology:PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2
... that the role of IT professional is one of diplomat between ... head of urgent communiqus and hushed conversations, exotic locales (like the ... of tense situations that could boil over into real conflict at ... deal of flexibility is the order of the day. , ...
... Competent businesses are adept at hiring and firing ... and deploying talent in ways that continuously grow ... achievements. Creating work environments that promote people agility ... imperative for companies seeking competitive advantage through their ...
... David Letterman, here are the top 10 reasons to be at ... can pick up some great toys for the kids. Attention-grabbing ... floor, where representatives of 61 nations and 48 states have set ... the giveaways. , , Crowd at BIO ...
Cached Biology Technology:IT is the New Foreign Service 2IT is the New Foreign Service 3Agility is the next talent management imperative 2Agility is the next talent management imperative 3Agility is the next talent management imperative 4From the BIO floor 2From the BIO floor 3
... 45° Fixed Angle Rotor ... Centra CL2, Centra CL3CL3R, and ... concentration of sputum samples and ... samples. Provides individual aerosol containment. ...
Buckets for 2 racks of 5 tubes, type Stago/Hitachi...
Buckets for tube holder inserts...
Rotor for four tube-loaded buckets; ma RCF 2550g; sold without buckets...
Biology Products: