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Chimpanzee study reveals genome variation hotspots

Researchers believe that dynamic regions of the human genome -- "hotspots" in terms of duplications and deletions -- are potentially involved in the rapid evolution of morphological and behavioral characteristics that are genetically determined.

Now, an international team of researchers, including a graduate student and an associate professor from Arizona State University, are finding similar hotspots in chimpanzees, which has implications for the understanding of genomic evolution in all species.

"We found that chimpanzees have many copy number variants -- duplications or deletions of large segments of DNA -- in the same regions of the genome as do humans. What this suggests is that some regions of the genomes are inherently unstable in both humans and chimpanzees," says George (P.J.) Perry, a Ph.D. anthropology student working with Anne Stone, an associate professor in ASU's School of Human Evolution and Social Change in the College of Liberal Arts and Sciences.

"This is a relatively new area of research and this is the first time this has been investigated on a genome-wide scale in a population sample of nonhuman primates," Perry says of the findings published May 15 in the online early edition of the journal Proceedings of the National Academy of Sciences (PNAS).

Perry, who is the study's lead author, says: "These copy number variants may be very significant from an evolutionary perspective, and they're important to study and understand. We talk about genetic diseases and cures, but first you have to find out that genetic differences such as copy number variants are there. And then you can study what they're involved in and what they mean from a morphological variation and disease standpoint."

Specifically, the study of the processes that lead to variations and mutations within a species can help researchers understand the evolution of copy number differences between species, Perry explains.

"Ultimately, we can use
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Source:Arizona State University


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