Navigation Links
Chewing up a key regulator of fat synthesis keeps mice lean despite a high-fat diet

only during fasting, when ACC should be turned off. Heredia and co-first author Ling Qi, Ph.D., reasoned that keeping the TRB3 pathway artificially "on" during both fasting and feeding might melt away fat depots.

And that's exactly what happened. Mice genetically engineered to express permanently elevated levels of TRB3 protein in fat tissue were 10-20 percent skinnier than normal mice. "Even when we put them on a high-fat diet, these mice just didn't gain any weight," says Qi. "Their physical activity was the same, but they were constantly burning fat."

All this is good news for the fight against obesity and the disorders characterized by insulin-resistance known as "metabolic syndrome." Most people with insulin resistance will develop type 2 diabetes within 10 years, unless they lose 5 to 7 percent of their body weight--about 10 to 15 pounds for someone weighing 200 pounds. Defining how molecules regulating fat storage interact could lead to novel measures to curb obesity.

Further evidence linking TRB3 to disease comes from recent findings from a team of Italian scientists who report that mutations in the human TRB3 gene are associated with several insulin resistance-related health problems, such as high insulin levels, high cholesterol, and cardiovascular disease.

Achieving a desired physiological outcome by manipulating basic biochemistry was clearly satisfying for Montminy. "What really made this an interesting story is that the molecular mechanism and the biology intersected since we were able to explain how TRB3 made the mice lean," he reflects. "That doesn't happen very often."

Additional contributors to this study included assistant professor Robert Screaton, Ph.D., formerly at the Salk, now at Children's Hospital of Eastern Ontario; Judith Y. Altarejos, Ph.D., Naomi Goebel, Michael Nelson, Ph.D., professor Ronald M. Evans, Ph.D., all at the Salk Institute; Sherry Niessen, Ian X. MacLeod, and Professor John Yates, P
'"/>

Source:Salk Institute


Page: 1 2 3

Related biology news :

1. White blood cell waste disposal system plays critical regulatory role
2. Researchers rein in regulatory RNAs
3. OneWorld Health drug receives Orphan designation from U.S. and European regulatory agencies
4. Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance
5. New technique helps identify multiple DNA regulatory sites
6. An essential regulator of body weight revealed
7. Master regulatory gene found that guides fate of blood-producing stem cells
8. Smoking damages key regulatory enzyme in the lung
9. Key brain regulatory gene shows evolution in humans
10. New methods offer insight into regulatory DNA
11. Research reveals control of potent immune regulator
Post Your Comments:
(Date:7/25/2014)... In the first broad-scale estimate of air pollution removal ... calculated that trees are saving more than 850 human ... respiratory symptoms. , While trees, pollution removal equated to ... percent, the impacts of that improvement are substantial. Researchers ... pollution at nearly $7 billion every year in a ...
(Date:7/25/2014)... the colonial era, 100,000s of people lived on the ... manipulated fire to control the availability of plants they ... continue to use fire to maintain desired habitat and ... U.S. Forest Service,s Pacific Southwest Station, will lead a ... Wildfire Refuge during the Ecological Society of America,s 99th ...
(Date:7/25/2014)... Terra satellite show the different areas that have been affected ... The burn scars show up as reddish-brown splotches of color ... the remote parts of Eastern Russia in the Sakha Republic. ... instrument, it is still possible to see the smoke rising ... below show the devastating number of fires that have plagued ...
Breaking Biology News(10 mins):First national study finds trees saving lives, reducing respiratory problems 2Fire ecology manipulation by California native cultures 2Fire ecology manipulation by California native cultures 3
... ON, July 19, 2013 Kidney patients who take calcium ... 22 per cent higher risk of death than those who ... by Women,s College Hospital,s Dr. Sophie Jamal. The study, ... the long-time practice of prescribing calcium to lower phosphate levels ...
... This news release is available in German . ... of text, the brain sends commands to arms and fingers to tap ... transfer this information as electrical pulses that trigger muscles to move. The ... along the spinal cord. For a long time, scientists assumed that ...
... media has expanded to reach an unlikely new target: ... Technology (NIST) have created networks of molecular data similar ... search would allow Facebook users to find all their ... NIST-designed networks could help scientists rapidly sift through enormous ...
Cached Biology News:Calcium linked to increased risk of heart disease and death in patients with kidney disease 2Haste and waste on neuronal pathways 2Haste and waste on neuronal pathways 3Haste and waste on neuronal pathways 4Facebook for molecules 2Facebook for molecules 3
(Date:7/26/2014)... Canada Endoscopy Visualization Systems Market Outlook ... Canada Endoscopy Visualization Systems market. The report provides ... units) and average prices (in US dollars) within ... Endoscopy Visualization Systems and Low-End Endoscopy Visualization Systems. ... , The report also provides company shares and ...
(Date:7/25/2014)... July 26, 2014 "Ischemic Stroke ... 2014" provides data on the Ischemic Stroke and ... elemental information and data relating to the clinical ... View full global Ischemic Stroke Research Report 2014 ... overview of the trial numbers and their recruitment ...
(Date:7/25/2014)... 2014 Amgen (NASDAQ: AMGN ) ... $0.61 per share dividend for the third quarter of ... 2014, to all stockholders of record as of the ... About Amgen Amgen is committed to unlocking the ... by discovering, developing, manufacturing and delivering innovative human therapeutics. ...
(Date:7/25/2014)... live in each person,s digestive tract. Scientists believe that ... off harmful infections, but their role in human health ... on the role of these bacteria, a team of ... tracked fluctuations in the bacterial populations of two research ... the July 25 issue of the journal Genome ...
Breaking Biology Technology:Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 2Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 3Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 4Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 5Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 2Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 3Amgen Announces 2014 Third Quarter Dividend 2Amgen Announces 2014 Third Quarter Dividend 3Monitoring the rise and fall of the microbiome 2Monitoring the rise and fall of the microbiome 3
... Materials Research Laboratory at UC Santa Barbara: an NSF ... from the National Science Foundation (NSF) to carry out ... years. Renewed NSF support ensures the vitality of materials ... energy, environment, and sustainability. Despite the challenging budgetary ...
... Sept. 12, 2011 McKesson Corporation ... McKesson Specialty Health , focused on empowering the ... technology and quality of care. (Logo:   ... support and business solutions, McKesson Specialty Health offers the ...
... Sept. 9, 2011 Palatin Technologies, Inc. (NYSE Amex: ... the Rodman & Renshaw Annual Global Investment Conference on Tuesday, ... will be held at The Waldorf Astoria in New York, ... Executive Officer of Palatin Technologies, will provide an update on ...
Cached Biology Technology:Major grant from the National Science Foundation will sustain UCSB materials research through 2017 2Major grant from the National Science Foundation will sustain UCSB materials research through 2017 3McKesson Corporation Unveils New Offerings to Empower the Community Patient Care Delivery System 2McKesson Corporation Unveils New Offerings to Empower the Community Patient Care Delivery System 3
capacity 250 mL...
... This CLS number is ... created to easily match ... showing no availability yet, ... old Sigma-Aldrich number (Z35,347-7) ...
Certified by the Biological Stain Commission. For staining fresh peripheral blood smears and blood parasites....
... Aminopropylsilane is perhaps the ... chemistry for microarray experiments. ... for Microarrays provide a ... for printing PCR products ...
Biology Products: