Navigation Links
Chemists synthesize molecule that helps body battle cancers, malaria

The first synthesis of QS-21A, a medicinally important molecule that helps the body battle disease, has been achieved by chemists at the University of Illinois at Urbana-Champaign.

In clinical trials, QS-21A has been shown to significantly improve the body's immune response in vaccine therapies against aggressive diseases such as melanoma, breast cancer, small-cell lung cancer, prostate cancer, HIV-1 and malaria. An extract from the bark of the South American tree Quillaja saponaria Molina, QS-21A is available only in small quantities.

"Now that we have synthesized this remarkable molecule and confirmed its structure, we are in a position to examine how it works and investigate ways to improve its performance," said David Y. Gin, a professor of chemistry at Illinois. Gin and his collaborators describe their work in a paper that has been accepted for publication in the Journal of the American Chemical Society, and posted on its Web site.

An extremely powerful adjuvant, QS-21A enhances the potency of antigens introduced in the body to elicit an immune response, allowing for lower vaccine doses with greater effectiveness. The molecule could therefore save patients money on expensive drugs and stretch limited supplies of antigens and vaccines.

Gin and his collaborators are now exploring ways to improve the molecule. By investigating structure activity relationships, they want to strip away nonessential structures, leaving a simpler and more potent core.

"One frequent problem encountered with vaccines is ensuring that the vaccine is potent enough to elicit a strong immune response," Gin said. "We will continue looking for ways to produce new molecules similar to QS-21A that will enhance the body's natural immune response to eradicate diseases."


'"/>

Source:University of Illinois at Urbana-Champaign


Page: 1

Related biology news :

1. Chemists create Superbowl molecule; May lead to better health
2. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
3. Chemists identify key gene in development of type 1 diabetes
4. Chemists identify immune system mechanism for methamphetamine binges
5. Key molecule in plant photo-protection identified
6. Inflammatory molecules released by pollen trigger allergies
7. Researchers discover molecule that causes secondary stroke
8. Yale researchers identify molecule for detecting parasitic infection in humans
9. Scientists identify molecule that regulates well-known tumor suppressor
10. Medical molecules designed to respond to visible light that can penetrate tissue
11. Researchers find promising cancer-fighting power of synthetic cell-signaling molecule
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology: