Navigation Links
Chemists identify immune system mechanism for methamphetamine binges

Chemists at The Scripps Research Institute have found evidence in laboratory studies that the immune system may be able to recognize methamphetamine and boost tolerance to the drug through an unusual vaccine-like mechanism. Their finding, if confirmed in human studies, could help explain why chronic users go on long binges with the illicit drug, also known as speed. The study could lead to new treatments for the drug's addiction, they say.

Recent studies by others have documented the drug's apparent ability to suppress the immune system, making abusers more vulnerable to diseases such as HIV. The new study is the first to suggest that the drug can engage the body's defense system to attack methamphetamine in such a way that makes users inclined to use more of the drug, the researchers say. Their study, which paints a clearer picture of the drug's effect on the immune system and its potential for abuse, was described today at the 229th national meeting of the American Chemical Society, the world's largest scientific society.

"Test animals injected with methamphetamine actually developed antibodies to the drug, which is highly unique for a molecule of its relatively small size," says study co-leader Kim Janda, Ph.D., a chemist at Scripps in La Jolla, Calif. Developing antibodies to the body's invaders, such as viruses and bacteria, is normally a good thing and forms the basis of modern vaccines, he explains. But ironically, people who abuse methamphetamine may build up antibodies to the drug itself, so they require increasing amounts to get high, resulting in binging behavior, he says.

"Without knowing it, they're essentially vaccinating themselves against the drug, and that's not a good thing as it requires more of the drug to get high," says Janda. His findings were first reported in a recent issue of the Journal of the American Chemical Society, the Society's peer-reviewed journal.

In a test tube study designed to simulate the chemica
'"/>

Source:American Chemical Society


Page: 1 2 3

Related biology news :

1. Chemists create Superbowl molecule; May lead to better health
2. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
3. Chemists identify key gene in development of type 1 diabetes
4. Chemists synthesize molecule that helps body battle cancers, malaria
5. Fox Chase Cancer Center scientists identify immune-system mutation
6. Researchers identify target for cancer drugs
7. Scientists identify genetic pathways essential to RNA interference
8. Scientists identify molecular events that drive cell senescence
9. Scientists identify new model Of NK cell development
10. Yale researchers identify molecule for detecting parasitic infection in humans
11. Wisconsin researchers identify sleep gene
Post Your Comments:
(Date:7/24/2014)... 24, 2014) Scientists at The New York ... step closer to creating a viable cell replacement ... cells. , For the first time, NYSCF ... from skin samples of patients with primary progressive ... protocol to induce these stem cells into becoming ...
(Date:7/24/2014)... Bushmeat, the use of native animal species for food ... be a significant factor in the decline of many ... new study indicates that more than half of the ... raptors and hornbills., "By surveying not only the meat ... being eaten inside the forest by hunters and brought ...
(Date:7/24/2014)... current biodiversity, the product of 3.5 billion years of ... history of life. But it may be reaching a ... literature and analysis of data published in Science ... loss and decline of animals is contributing to what ... sixth mass biological extinction event. , Since 1500, more ...
Breaking Biology News(10 mins):NYSCF scientists one step closer to cell therapy for multiple sclerosis patients 2Stanford biologist warns of early stages of Earth's 6th mass extinction event 2Stanford biologist warns of early stages of Earth's 6th mass extinction event 3
... pay more for meals prepared with produce and meat ... meals actually increases when the price increases, according to ... of how customers perceive and value local food shows ... when they are priced slightly higher than meals made ...
... a poorly understood class of RNA produced in a mammal,s ... of the infection. Their findings are reported today in ... Microbiology. RNA (ribonucleic acid) contains information transcribed from the ... these RNAs translate sections of DNA code into building blocks ...
... New University of Florida research puts to rest the ... glacial period. It turns out it ended up in the ... findings have implications for modern-day global warming, said Ellen Martin, ... paper, which is published in this week,s journal Nature ...
Cached Biology News:Restaurant customers willing to pay more for local food 2New class of biomolecules triggered in response to respiratory virus infection 2New class of biomolecules triggered in response to respiratory virus infection 3New class of biomolecules triggered in response to respiratory virus infection 4UF research gives clues about carbon dioxide patterns at end of Ice Age 2UF research gives clues about carbon dioxide patterns at end of Ice Age 3
(Date:7/25/2014)... Pa. , July 25, 2014 /PRNewswire-iReach/ -- ... and consulting for global corporations operating in highly ... host its first annual Global User Group Conference, ... historic Philadelphia, Pennsylvania at ... - http://photos.prnewswire.com/prnh/20140724/130263 This ...
(Date:7/24/2014)... New York, NY - July 24, 2014 -- Keryx ... results from the long-term, randomized, active control Phase 3 ... ferric iron-based phosphate binder, for the treatment of hyperphosphatemia ... The PERFECTED study (PhosphatE binding and iRon delivery with ... the Journal of the American Society of Nephrology ...
(Date:7/24/2014)... Calif. , July 24, 2014  Now available ... to home. Rehealth Regenerative Therapies , located in ... and other physically active people a new health option: ... Regardless of age, countless patients suffer from joint ... activities, such as muscle tears, torn rotator cuff, tennis ...
(Date:7/24/2014)... Security forces worldwide rely on sophisticated equipment, trained ... other public areas against terrorist attacks. A revolutionary ... about to make their job much easier. , ... Patolsky of Tel Aviv University ,s School of ... developed by the Herzliya company Tracense, picks up ...
Breaking Biology Technology:Xybion Announces It Will Host International User Conference in Philadelphia 2Xybion Announces It Will Host International User Conference in Philadelphia 3Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 4Stem Cells In Sports Injuries, Joints And Muscular Pain 2Stem Cells In Sports Injuries, Joints And Muscular Pain 3Nano-sized chip 'sniffs out' explosives far better than trained dogs 2
... , , , ... became the only hospital in the Midwest to acquire a dual console ... States to purchase the new system. , , ... the latest robotic-assisted surgery system that gives surgeons an enhanced three-dimensional view ...
... , , , , ... Inc. (Nasdaq: RGDX ) announced today that it has entered ... Partnership to raise approximately $4 million from the private placement of 3,057,907 ... $1.30 per share. The closing of the sale of the shares occurred ...
... , , , ... (NYSE: ARE ), Landlord of Choice to the Life ... long-term lease with Eli Lilly and Company as the anchor tenant ... Science Park ("the Alexandria Center"). Lilly has leased approximately 91,000 ...
Cached Biology Technology:St. John's Hospital Acquires Latest Technology in Robotic-Assisted Surgery 2Response Genetics Announces $4 Million Private Placement 2Response Genetics Announces $4 Million Private Placement 3Alexandria Real Estate Equities, Inc. Signs Biopharmaceutical Company, Lilly, as Anchor New York City Tenant at the Alexandria Center for Science and Technology 2Alexandria Real Estate Equities, Inc. Signs Biopharmaceutical Company, Lilly, as Anchor New York City Tenant at the Alexandria Center for Science and Technology 3Alexandria Real Estate Equities, Inc. Signs Biopharmaceutical Company, Lilly, as Anchor New York City Tenant at the Alexandria Center for Science and Technology 4
Screening assay to detect the Listeria monocytogenes in food samples by,DNA amplification and molecular hybridization on a microtiter plate....
... CopyControl™ vector can be induced prior to ... provide the stability of single-copy BACs with ... other cloning vectors. The kits provide the ... insert size screening system) necessary to create ...
... PCR Enhancer (with betaine) substantially improves ... and specificity for amplification of many ... in PCR eliminates the base-pair composition ... thermal stability, suppresses pauses of DNA ...
... Systems provide rapid, precise localization of ... frozen or paraffin-embedded tissue, cytospins and ... facilitate double or triple labeleing experiments, ... with primary antibodies of different animal ...
Biology Products: