Navigation Links
Chemical switch triggers critical cell activities

The freeze-frame image of a molecular relay race, in which one enzyme passes off a protein like a baton to another enzyme, has solved a key mystery to how cells control some vital functions, according to investigators at St. Jude Children's Research Hospital. A report on this work appears in the January 14 advanced online publication issue of Nature.

The St. Jude discovery explains how a simple chemical link between molecules called a thioester bond acts like a switch to control the handoff of a protein called NEDD8 like a baton from one enzyme called E1 to a second enzyme called E2. When attached to E2, this thioester bond allows E2 to bind to a third enzyme called E3, which then helps E2 hand NEDD8 off to the ultimate target molecule at the end of the race. In the cell, this NEDD8 relay race triggers a number of biochemical reactions, one of which takes the brakes off cell division, allowing cells to multiply, according to the researchers. These thioester bonds are chemical links between two biological molecules that form when a sulfur atom on one of the molecules binds to an atom that is part of the other molecule.

Understanding how the thioester bond switch works is important not only because it explains a critical step in the NEDD8 hand-off from E1 to E2, but also because enzymes related to E1 and E2 run similar relays with other important protein batons, said Brenda Schulman, Ph.D., associate member of the St. Jude Structural Biology and Genetics and Tumor Cell Biology departments. "Our study shows that this simple switch could control comparable relays in charge of several different biochemical activities that keep cells alive and functioning normally." Schulman, a Howard Hughes Medical Institute (HHMI) investigator, is senior author of the Nature report.

Scientists already knew that E1 momentarily juggles two NEDD8 molecules at once, holding them in two different "hands." They also knew that E2 takes the NEDD8 that is in E1's le
'"/>

Source:St. Jude Children's Research Hospital


Page: 1 2 3

Related biology news :

1. Chemicals in tattoo inks need closer scrutiny
2. Roots Engage in Underground Chemical Warfare
3. Chemical Engineer Kao Explores Antibiotic Synthesis With DNA Chips
4. Chemical band-aid prevents heart failure in mice with muscular dystrophy
5. Chemical compound inhibits tumor growth, size in new mouse study
6. T-rays: New imaging technology spotlighted by American Chemical Society
7. Chemical warfare agent detection technology used to treat lung disease
8. Chemical guidance of T cells leads to immunologic memory and long-term immunity
9. Chemical signaling helps regulate sensory map formation in the brain
10. Chemical in many air fresheners may reduce lung function
11. Chemical tests of cell growth enter third dimension
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Chemical switch triggers critical cell activities

(Date:12/11/2014)... Research and Markets , ... http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition of the ...  report to their offering. One ... in technology. With continuous advances in technology, it ... latest standard that meets the needs and expectations ...
(Date:12/10/2014)... -- Valencell, a leader in performance biometric data sensor technology, ... its licensees for highly accurate, clinically validated biometric technology. ... from fitness and health sectors, but first responders/military and ... only as useful as the biometric data it delivers. ... long-term mass consumer adoption of wearable products," said Dr. ...
(Date:12/5/2014)... , Dec. 4, 2014 Increased ... boosted investments in new testing and inspection technologies. ... given rise to a range of innovative test ... requirements of Generation Y, which is generally more ... a result, product development strategies of test equipment ...
Breaking Biology News(10 mins):Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wearable Technology Products Demand Highly Accurate Biometric Technology 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4
... of its strategic plan, " Forging the Future A ... Genome Institute (DOE JGI) has positioned itself to provide the ... they can address pressing energy and environmental scientific challenges. ... the launch of the Emerging Technologies Opportunity Program (ETOP) ...
... Once famously described as "orphan diseases, too small to ... Hollywood drama "Lorenzo,s Oil," rare diseases are getting unprecedented ... research efforts and marketing new medicines that promise fuller ... conditions. That,s the finding of a major examination, ...
... own function by "accelerating and braking" is important basic knowledge ... cells are tweaked to produce more bioenergy. In a study ... Uppsala and Ume universities show a model of how cells, ... system similar to what can be found in today,s smartphones. ...
Cached Biology News:The DOE Joint Genome Institute expands capabilities via new partnerships 2The DOE Joint Genome Institute expands capabilities via new partnerships 3Cells must use their brakes moderately for effective speed control 2
(Date:12/22/2014)... 2014  ( www.competitivehealth.com ) — Competitive Health is ... review and advocacy service, has signed an agreement to ... discount health services marketplace. 63% of Americans ... they expected to pay. As part of an ongoing ... Savings is pleased to offer medical bill review and ...
(Date:12/22/2014)... ITRA Global, one of the largest organizations ... estate, has further expanded its global reach with the ... Western Australia, reports Mylinda Vick, CCIM, Chairman of the ... / ACORPP (Australian Corporate Property and Projects) , is ... services to a wide range of clients in the ...
(Date:12/19/2014)... December 19, 2014 Bioject Medical ... and manufacturer of needle-free injection technology, today announced ... Immunomic Therapeutics, Inc. (“ITI”) for ITI to use ... its LAMP™ vaccine platform. , In the ... Worldwide license to the Biojector®-2000 that triggers based ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2ITRA Global Continues International Expansion in Perth and Brisbane, Australia 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2
... past two years have been particularly difficult for telecom and high-technology ... Their own executives did them in, is a shout that I ... long. Now they have to compete, and they are falling on ... , ,But there is also truth to what a telecom President ...
... 11 Sonic Foundry a rich media solutions company, today ... Learning will use its Mediasite Live rich media Web ... presentations, and make them available on-demand via the Web ... ,Held Aug. 13-15 at the Monona Terrace Conference Center ...
... left the ministry years ago, but he hasn't given up ... and speaker on all things Internet spotlights old ways of ... , ,"The first requirement is to be willing to become ... about our culture that prevent us from encouraging, supporting, and ...
Cached Biology Technology:ARE WE THERE YET? 2Distance Education Conference Selects Sonic Foundry to Make Keynotes, Panel Presentations Available On-Demand 2Dream Thieme 2
Donor Goat Serum...
GeneRacer is an advanced RACE (rapid amplification of cDNA ends) technique that improves the efficiency of amplifying full-length 5' and 3' cDNA ends. With the GeneRacer Kit you can:...
... monoclonal [APS 26] to Presenilin 2 ... form of the disease carry mutations in ... amyloid precursor protein (APP). These disease-linked mutations ... form of amyloid-beta (main component of amyloid ...
One-step, microplate or cuvet, colorimetric, linear detection range 0.9 mg/dL to 200 mg/dL. Procedure: 2 min....
Biology Products: