Navigation Links
Chemical guidance of T cells leads to immunologic memory and long-term immunity

In the latest issue of the journal Nature, scientists at the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH) describe a new understanding about how long-term immunity works--findings that may lead to new ways of thinking about how to enhance certain immune responses and how to improve vaccines.

Led by immunologist Ronald Germain, M.D., Ph.D., the scientists took videos through a microscope to document what happens inside the lymph nodes of a living mouse shortly after a vaccination. The videos reveal that the movement of a specific type of immune cell known as a CD8+ T cell, also called a cytotoxic T cell, is not random as was previously thought, but instead is guided by chemical signals released from other cells.

Scientists have long recognized the importance of understanding how CD8+ T cells move through the lymph nodes and become activated. Once active, CD8+ T cells roam throughout the body destroying cells infected with bacteria or viruses--a process known as cell-mediated immunity. When these CD8+ T cells encounter an infected cell, they unleash a torrent of substances that poke holes in the cell's membrane, chew up its proteins and ultimately cause it to die. They also produce molecules such as interferon-gamma that help activate other immune cells.

After they fight the initial infection, some of these CD8+ T cells remain in the circulation as memory cells, primed to fight if the host is re-infected with the same pathogen. Memory cells are key to vaccine strategies being studied for infectious agents such as HIV. But the CD8+ T cells can only become effective, long-lived memory cells after they encounter certain other cells in the lymph node that can activate them.

The new research, conducted largely by senior postdoctoral fellows Flora Castellino, M.D., and Alex Huang, M.D., Ph.D., with Dr. Germain's guidance, shows that when CD8+ T cells enter the lymph node, a combinatio
'"/>

Source:NIH/National Institute of Allergy and Infectious Diseases


Page: 1 2 3

Related biology news :

1. Chemicals in tattoo inks need closer scrutiny
2. Roots Engage in Underground Chemical Warfare
3. Chemical Engineer Kao Explores Antibiotic Synthesis With DNA Chips
4. Chemical band-aid prevents heart failure in mice with muscular dystrophy
5. Chemical compound inhibits tumor growth, size in new mouse study
6. T-rays: New imaging technology spotlighted by American Chemical Society
7. Chemical warfare agent detection technology used to treat lung disease
8. Chemical signaling helps regulate sensory map formation in the brain
9. Chemical in many air fresheners may reduce lung function
10. Chemical tests of cell growth enter third dimension
11. Chemicals in brown algae may protect against skin cancer
Post Your Comments:
(Date:9/18/2014)... probably the ultimate form of camouflage: you don,t just ... strategy is not as uncommon as you might think. ... USA, explains that the larval life stages of many ... of the anatomy that most creatures cannot make transparent. ... to shield each individual eye unit with an opaque ...
(Date:9/17/2014)... UCLA atmospheric scientists were instrumental in the creation of ... tool to classify the fire threat potential of the ... a spark into an inferno. The index was introduced ... with UCLA and San Diego Gas and Electric. , ... to "extreme" that will be used to help fire ...
(Date:9/17/2014)... SAN DIEGO, Calif. (Sept. 17, 2014) A rare genetic ... autism, according to a recent joint investigation by researchers ... California, San Diego. In addition to suggesting better treatment ... offers more clues into the genetic underpinnings of autism., ... to the National Institutes of Health. It occurs in ...
Breaking Biology News(10 mins):Transparent larvae hide opaque eyes behind reflections 2UCLA scientists play key role in developing new Santa Ana Wildfire Threat Index 2A link between Jacobsen syndrome and autism 2
... 21, 2011) -- In a surprising new study, researchers ... software have made a startling discovery that rules out ... how bacteria self-organize into multicellular aggregate mounds. The study ... Georgia appears online this week in the Proceedings ...
... University of Illinois entomology professor and department ... Tyler Prize for Environmental Achievement, an international ... in an outstanding manner to scientific knowledge and ... of the world." Previous Tyler Prize recipients ...
... -- Marine biologists have solved a conundrum that has stumped ... It may sound simple, but the task is actually complex ... oceans, coral reefs and the marine life that populate them. ... scientists from the University of Miami (UM) and NOAA Fisheries ...
Cached Biology News:Biofilm reorganization: Back to the theoretical drawing board 2Biofilm reorganization: Back to the theoretical drawing board 3Illinois entomology professor May Berenbaum to receive 2011 Tyler Prize 2Illinois entomology professor May Berenbaum to receive 2011 Tyler Prize 3One fish, two fish … reef fish 2
(Date:9/18/2014)... (PRWEB) September 18, 2014 SeqLL ... Sequencing (tSMS™) technology, announced today the closing of ... investment, led by Genomic Diagnostic Technologies, will increase ... diagnostic applications. , Founded in March 2013 by ... Bioinformatics Analyst at Helicos BioSciences, SeqLL has continued ...
(Date:9/18/2014)... promoted as aids to weight loss and diabetes prevention, ... metabolic disease; and they do it in a surprising ... gut microbiota the substantial population of bacteria residing ... in mice and humans, were published today in ... of the Weizmann Institute,s Immunology Department, who led this ...
(Date:9/18/2014)... memory device for computing may have just taken an ... New York led by chemist Stephen O,Brien have discovered ... properties. , Combining both properties is very exciting scientifically ... for the devices that might ultimately be designed, in ... a single material, however, has proved difficult until now. ...
(Date:9/18/2014)... September 24 marks ASEA's "Meet ASEA" ... the manufacturer of the world's first and only redox ... , The Mexico City event features renowned speakers ... ASEA Field Leader Shawn Catmull from Draper, UT. , ... Physics from the University of Utah and devotes his ...
Breaking Biology Technology:SeqLL Closes Series-A Funding Round for Expansion of Single Molecule Sequencing 2Gut bacteria, artificial sweeteners and glucose intolerance 2Gut bacteria, artificial sweeteners and glucose intolerance 3Oxides discovered by CCNY team could advance memory devices 2Announcing the ASEA Mexico Grand Opening Tour Beginning September 18th 2
... Inc.,(Nasdaq: SSRX ), a leading biotechnology company ... in China, announces that David Chen, Chief Operating ... Unplugged Conference in New,York on Tuesday, September 9, ... the latest investor presentation will be available on ...
... Company, Inc. (IPM) today announced it was named ... fastest-growing private companies nationwide for a second consecutive ... to a broad range of industries, helping companies ... identified as one of the Chicago area’s top ...
... Mass., Aug. 25 Anthill Technologies, Inc. today,announced ... Zafgen, Inc. to apply,its high-speed chemistry technologies and ... Boston-based biopharmaceutical company which,develops obesity therapy based on ... the agreement, Anthill will use its ACOS(TM) high-speed ...
Cached Biology Technology: Integrated Project Management Named to "Inc. 5000" for Second Year : One of the Top 100 Fastest-Growing Companies in Chicago Area 2
Lyophilized solid. Suitable for evaluating functional activity of human complement components and for other research requiring a high level of hemolytic activity. ...
... systems are high-precision microarrayers capable of ... samples. VersArray ChipWriter Pro systems set ... and reproducibility to deliver unparalleled quality ... Their modular component design and flexible ...
Thermal printer paper is used with the thermal printer for the VersaFluor fluorometry systems. Supplied as 10 rolls....
... Gel extraction kit, 100 preps Storage: The kit ... For longer storage, keep all contents of the ... column purification kit utilizes a silica-gel based membrane ... fragments in the presence of specialized binding buffers. ...
Biology Products: