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Chemical 'band-aid' prevents heart failure in mice with muscular dystrophy

st P188 on mice with other types of dystrophies and see if it works as well when given as injections, rather than infusions.

Metzger emphasizes that it is uncertain whether P188 will have any clinical use in patients with muscular dystrophy. The material has been used for 24 hours to 72 hours in a phase III clinical trial for patients with sickle-cell anemia, but questions about the safety of long-term use remain.

"If issues of dosing and long-term safety can be resolved, our research suggests that poloxamer 188 could be a new therapeutic agent for preventing or limiting progressive damage to the hearts of patients with muscular dystrophy," Metzger says.


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Source:University of Michigan


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