Navigation Links
Chemical 'band-aid' prevents heart failure in mice with muscular dystrophy

t muscle cells, and vulnerable to damage when stretched.

"That's where poloxamer 188 comes in," Metzger adds. "It assists the heart to be more compliant during the relaxation phase ?allowing more blood to flow into the heart. We demonstrated this effect at the level of individual heart muscle cells, and it turned out to be true at the organ level, also."

The key to the U-M discovery was technology developed by Soichiro Yasuda, Ph.D., a post-doctoral fellow and co-first author of the study. He created a device to allow the simultaneous measurement of force and intracellular calcium concentration in individual myocytes as they are stretched. Yasuda's device uses microcarbon fibers stuck by electrostatic attraction to each end of a single cardiac myocyte. As the myocyte is stretched between the carbon fibers, a transmitter on one fiber measures the amount of stretch and a force transducer on the other fiber measures the contractile force of the cell in response to that stretch.

"It's like stretching a rubber band," Yasuda says. "You can do specific controlled stretches and record the force generated by the cell. We found that myocytes from normal mice easily handled a 20 percent stretch in length, while myocytes from dystrophin-deficient or mdx mice had about 70 percent more passive tension in response to the stretch. Compared to normal myocytes, mdx myocytes were stiffer and resistant to stretching. When they were stretched repeatedly, they started shaking and eventually contracted and died."

"It's a physiologically relevant test, because it mimics what happens in the heart muscle when myocytes must relax and stretch to make room for incoming blood filling the heart," says Metzger, who is affiliated with the U-M's Cardiovascular Center. "This shows, for the first time, the effect of a deficit of dystrophin on individual cardiac myocytes. Our hypothesis was that stretching created small tears or holes in the myocyte membrane, which allow
'"/>

Source:University of Michigan


Page: 1 2 3 4

Related biology news :

1. Chemicals in tattoo inks need closer scrutiny
2. Roots Engage in Underground Chemical Warfare
3. Chemical Engineer Kao Explores Antibiotic Synthesis With DNA Chips
4. Chemical compound inhibits tumor growth, size in new mouse study
5. T-rays: New imaging technology spotlighted by American Chemical Society
6. Chemical warfare agent detection technology used to treat lung disease
7. Chemical guidance of T cells leads to immunologic memory and long-term immunity
8. Chemical signaling helps regulate sensory map formation in the brain
9. Chemical in many air fresheners may reduce lung function
10. Chemical tests of cell growth enter third dimension
11. Chemicals in brown algae may protect against skin cancer
Post Your Comments:
(Date:8/19/2014)... August 19, 2014A new ovoid structure discovered in the ... contains a variety of minerals, and shows evidence of ... melting of the permafrost and mixing of surface and ... range of analytical studies to determine the origin of ... how this ovoid formed, point to the most likely ...
(Date:8/19/2014)... that analyzed concentrations of African dust transported to ... and spring. These research findings offer new insight ... impacts of African dust, including the climate change-induced ... from increased African dust emissions in the coming ... Rosenstiel School of Marine and Atmospheric Science and ...
(Date:8/19/2014)... available in French . ... and RISKS of physical activity in children,Today the Canadian ... promotion of childhood physical activity and published their position ... and Metabolism ( APNM ). This position ... area of risk of physical activity for children and ...
Breaking Biology News(10 mins):Life on Mars? Implications of a newly discovered mineral-rich structure 2Study of African dust transport to South America reveals air quality impacts 2Taking a stand: Balancing the BENEFITS and RISKS of physical activity in children 2Taking a stand: Balancing the BENEFITS and RISKS of physical activity in children 3
... variants related to a risk factor for sudden cardiac ... journal Nature Genetics identifies variants in genes, ... QT interval measured on the electrocardiogram (EKG) performed routinely ... prevent sudden cardiac death and arrhythmia by limiting the ...
... Building on these findings, the Helmholtz scientists and their ... pathogenesic mechanisms of the disease and gain perspectives for ... study have been published online in the journal ... international research consortium QTSCD (QT Interval and Sudden Cardiac ...
... 2009 A review by researchers at Northwestern University ... of the utility of probiotics in the treatment of ... 35624 was the only probiotic strain out of ... improve symptoms of IBS, including abdominal pain, bloating and ...
Cached Biology News:Common gene variants influence risk factor for sudden cardiac death 2Common gene variants influence risk factor for sudden cardiac death 3Genetic risk factors identified for sudden cardiac death 2Genetic risk factors identified for sudden cardiac death 3Review of probiotic trial research finds only Bifantis able to claim efficacy for IBS symptoms 2
(Date:8/19/2014)... (PRWEB) August 19, 2014 Sales Horizons, ... of its online sales skills training course ... skills. , MedTech clinical staff spend the majority of ... hospital, standalone medical center, or physician practice – providing ... But why stop there? Sales Horizons believes clinical staff ...
(Date:8/18/2014)... --  Sterne, Kessler, Goldstein & Fox P.L.L.C. , an ... , announced today that it has filed eleven ... the U.S. Patent and Trademark Office (USPTO) on behalf ... (Nasdaq: BRLI).  These IPR petitions aim to nullify eleven ... These patents have been asserted against GeneDx in patent ...
(Date:8/18/2014)... , Aug. 18, 2014 TNI BioTech, Inc. ... pioneering the manufacturing and marketing of innovative therapies for ... Company is providing a second notice of TNI BioTech,s ... making the announcement, Noreen Griffin , founder and ... advance for your participation in the Annual Meeting. On ...
(Date:8/16/2014)... $229,214 grant from the Walmart Foundation to build a ... cut the manufacturing costs of goods, allowing those goods ... formerly built overseas. , The Walmart U.S. Manufacturing Innovation ... in awards to seven research and development institutions at ... through the collaboration between Walmart, the U.S. Conference of ...
Breaking Biology Technology:Sales Horizons Launches a New Online Sales Training Course for MedTech Clinical Staff to Develop Their Sales Skills 2Sales Horizons Launches a New Online Sales Training Course for MedTech Clinical Staff to Develop Their Sales Skills 3Sterne Kessler Files 11 IPR Petitions On Behalf Of GeneDx, Inc., Subsidiary Of BioReference Laboratories, Inc. 2Sterne Kessler Files 11 IPR Petitions On Behalf Of GeneDx, Inc., Subsidiary Of BioReference Laboratories, Inc. 3TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 2TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 3TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 4UT Arlington receives Walmart, Walmart Foundation innovation grant 2UT Arlington receives Walmart, Walmart Foundation innovation grant 3
... know them, from televisions to computers, depend on conducting materials ... pocket sized communications devices and microchips that can fit on ... big demand. Now, Prof. Eran Rabani of Tel Aviv ... Faculty of Exact Sciences, in collaboration with Profs. Uri Banin ...
... 2011 PharmAthene, Inc. (NYSE Amex: PIP ... and chemical threats, today announced that the Company,s Board ... John Pappajohn as Chairman of the Board. Mr. Pappajohn ... Dr. Sayare has been a member of PharmAthene,s ...
... Quest Diagnostics (NYSE: DGX ), ... and services, and Genomic Vision, a biotechnology company dedicated ... a multi-year exclusive collaboration involving Genomic Vision,s proprietary ... terms of the agreement, Quest Diagnostics has exclusive ...
Cached Biology Technology:Conducting energy on a nano scale 2Conducting energy on a nano scale 3Mitchel Sayare, Ph.D. to Succeed John Pappajohn as Chairman of the Company's Board of Directors 2Mitchel Sayare, Ph.D. to Succeed John Pappajohn as Chairman of the Company's Board of Directors 3Quest Diagnostics and Genomic Vision Form Strategic Collaboration to Develop Genome-based Laboratory Tests 2Quest Diagnostics and Genomic Vision Form Strategic Collaboration to Develop Genome-based Laboratory Tests 3Quest Diagnostics and Genomic Vision Form Strategic Collaboration to Develop Genome-based Laboratory Tests 4
... Staccato Series of systems provide fast ... drug discovery, genomics, proteomics and drug ... in three base configurations; Mini Workstation ... Series. All Staccato Application Series ...
... Workstation fully automates pharmaceutical sample preparation ... sample transfer, mixing and dilutions. Capabilities ... detection. The Prelude performs these functions ... Part 11. The Prelude performs ...
... any standard fixed-angle microcentrifuge rotor at ... centrifuge tube filters consist of a ... tube. They filter by centrifugation for ... preparation, removal of cells from media ...
... seal tabs • Reusable, press-to-seal gasket ... quickly assembled and disassembled for hybridizing and ... any thickness with up to a 13 ... per slide. Minimize specimen handling, eliminate evaporation ...
Biology Products: